Route of administration (physiological factor influencing absorption)
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-don't give oral peptide drugs because of their instability in GI tract would
give it parenterally
,Skin barrier is not ___
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perfect
Rectal Route
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-irregular and incomplete absorption
*partial avoidance of first pass effect:superior rectal vein pours into hepatic
portal vein
-drugs can irritate rectal mucosa
Intercellular transport
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-most common pathway for transport across skin
-thickness of SC is very small but the nature of the diffusion pathway
around the cells increases the resistance through the skin
Intravenous disadvantages
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, -neither removed nor its absorption retarded following overdose
-embolism
-introduction of bacteria
-precipitation of blood contents
-DON'T administer insoluble drugs or oils via this route
Rectal advantages
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-labile drugs can bypass harsh environment
-compliance with unconscious patients or patients with swallowing issues
Small intestine absorption
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-large surface area
-high blood perfusion
-high capacity for absorption
-diarrhea decreases intestinal transit time and decreases drug absorption
-weak acids absorbed in stomach but more so in intestine major process is
diffusion
Intravenous injection
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Give this one a try later!
-don't give oral peptide drugs because of their instability in GI tract would
give it parenterally
,Skin barrier is not ___
Give this one a try later!
perfect
Rectal Route
Give this one a try later!
-irregular and incomplete absorption
*partial avoidance of first pass effect:superior rectal vein pours into hepatic
portal vein
-drugs can irritate rectal mucosa
Intercellular transport
Give this one a try later!
-most common pathway for transport across skin
-thickness of SC is very small but the nature of the diffusion pathway
around the cells increases the resistance through the skin
Intravenous disadvantages
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, -neither removed nor its absorption retarded following overdose
-embolism
-introduction of bacteria
-precipitation of blood contents
-DON'T administer insoluble drugs or oils via this route
Rectal advantages
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-labile drugs can bypass harsh environment
-compliance with unconscious patients or patients with swallowing issues
Small intestine absorption
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-large surface area
-high blood perfusion
-high capacity for absorption
-diarrhea decreases intestinal transit time and decreases drug absorption
-weak acids absorbed in stomach but more so in intestine major process is
diffusion
Intravenous injection
Give this one a try later!
