Graphically represents the relationship between the dose of a drug and the response
it produces.
Give this one a try later!
Dose-response curve
Binds to the same receptors as another agonist but produces the opposite effect.
,Give this one a try later!
Inverse agonist
An extracellular substance that binds to cell surface receptor and initiates an
intracellular activity.
Neurotransmitters- acetylcholine, serotonin
Give this one a try later!
First Messenger
Exist within the body
Are always agonists
Give this one a try later!
Endogenous Ligands
Prevents a response from occurring.
A drug that has an affinity for a receptor but displays little or no intrinsic activity.
Can be competitive or noncompetitive
Give this one a try later!
Antagonist
, The rapid development of complete tolerance. It becomes necessary to interrupt
therapy
Give this one a try later!
Tachyphylaxis
Change in receptors
Loss of receptors
Exhaustion of mediators
Increased metabolic degradation of the drug
Physiological adaption
Give this one a try later!
Drug resistance sources
The sub-maximal effect with all receptors activated.
Can act as an antagonist in the presence of a full agonist.
Give this one a try later!
Partial agonist
Competes with the agonist (other ligands) for receptor sites.
almost all antagonists are competitive
it produces.
Give this one a try later!
Dose-response curve
Binds to the same receptors as another agonist but produces the opposite effect.
,Give this one a try later!
Inverse agonist
An extracellular substance that binds to cell surface receptor and initiates an
intracellular activity.
Neurotransmitters- acetylcholine, serotonin
Give this one a try later!
First Messenger
Exist within the body
Are always agonists
Give this one a try later!
Endogenous Ligands
Prevents a response from occurring.
A drug that has an affinity for a receptor but displays little or no intrinsic activity.
Can be competitive or noncompetitive
Give this one a try later!
Antagonist
, The rapid development of complete tolerance. It becomes necessary to interrupt
therapy
Give this one a try later!
Tachyphylaxis
Change in receptors
Loss of receptors
Exhaustion of mediators
Increased metabolic degradation of the drug
Physiological adaption
Give this one a try later!
Drug resistance sources
The sub-maximal effect with all receptors activated.
Can act as an antagonist in the presence of a full agonist.
Give this one a try later!
Partial agonist
Competes with the agonist (other ligands) for receptor sites.
almost all antagonists are competitive
