TSH and T3/4 lab values in Hypo/Hyperthyroidism
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Hypo: elevated TSH, low T3/4
Hyper: low TSH, elevated T3/4
TSH usually checked first
,Sarcomas
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Connective tissue
Carcinoma in situ fates
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1. Stable for long time
2. Progress to invasive / metastatic cancer
3. Regress and disappear
time in situ is unknown; watchful waiting or prophylactic Tx (removal)
Autosomal dominant
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Phenotype expressed in those who only have one copy of gene mutation
Key components to accurate family history (genogram)
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, -dead, no disease
-dead, disease diagnosis year
-disease and diagnosis year
-no disease (alive)
Autosomal recessive
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Phenotype expressed in those who have two copies of gene mutation
Gene Translocation
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Chromosomal alteration; whole/segment chromosome becomes attached
or interchanged with another whole/segment chromosome
Gene silencing
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DNA methylation
histone modification
microRNAS
, DM symptoms
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Polydipsia
Polyuria
Polyphagia
Fatigue
Recurrent infection
Slow wound healing
Vision changes
Paresthesias/neuropathy
Breast cancer risks
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55+, white people, genetics (BRCA1+2), obesity, diet, alcohol, hormones
1/8 develop in lifetime
Hyperthyroid symptoms
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Exophthalmos, weight loss, diarrhea, tachycardia, warm skin, thin hair,
pretibial edema
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Hypo: elevated TSH, low T3/4
Hyper: low TSH, elevated T3/4
TSH usually checked first
,Sarcomas
Give this one a try later!
Connective tissue
Carcinoma in situ fates
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1. Stable for long time
2. Progress to invasive / metastatic cancer
3. Regress and disappear
time in situ is unknown; watchful waiting or prophylactic Tx (removal)
Autosomal dominant
Give this one a try later!
Phenotype expressed in those who only have one copy of gene mutation
Key components to accurate family history (genogram)
Give this one a try later!
, -dead, no disease
-dead, disease diagnosis year
-disease and diagnosis year
-no disease (alive)
Autosomal recessive
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Phenotype expressed in those who have two copies of gene mutation
Gene Translocation
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Chromosomal alteration; whole/segment chromosome becomes attached
or interchanged with another whole/segment chromosome
Gene silencing
Give this one a try later!
DNA methylation
histone modification
microRNAS
, DM symptoms
Give this one a try later!
Polydipsia
Polyuria
Polyphagia
Fatigue
Recurrent infection
Slow wound healing
Vision changes
Paresthesias/neuropathy
Breast cancer risks
Give this one a try later!
55+, white people, genetics (BRCA1+2), obesity, diet, alcohol, hormones
1/8 develop in lifetime
Hyperthyroid symptoms
Give this one a try later!
Exophthalmos, weight loss, diarrhea, tachycardia, warm skin, thin hair,
pretibial edema