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AAMC FL 1 Bio Questions with
Detailed Verified Answers
Question: Based on the data presented in the passage, which statement best
describes the HSP110ΔE9 allele?
A.Cancer-promoting and dominant to HSP110WT
B.Cancer-promoting and recessive to HSP110WT
C.Cancer-suppressing and dominant to HSP110WT
D.Cancer-suppressing and recessive to HSP110WT
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Ans: Solution: The correct answer is C.
This is a Biology question that falls under the content category
"Transmission of genetic information from the gene to the protein." The
answer to this question is C. According to Figure 1, as compared to
HSP110WT, HSP110ΔE9 slows tumor growth, and thus, it is cancer-
suppressing. According to the data in Table 2, HSP110ΔE9 counteracts the
ability of HSP110WT to prevent protein aggregation and prevent
apoptosis; thus, the HSP110ΔE9 allele is dominant to the HSP110WT
allele. This is a Data-based and Statistical Reasoning question as it
required interpretation of data in Figure 1 and Table 2.
Cancer causes rapid cell division, usually with some broken DNA repair
machinery. This causes tons of mutations within the genome. This is likely
how HSP110 gets mutated in the first place. There is probably a more
complicated mechanism behind this, but we don't get that information
from the passage.
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Normal HSP110 in a healthy cell helps protein folding. This helps the cell
grow and divide, among other things. Cancer cells want to grow and
divide, so they like to have normal HSP110. Unfortunately for them, they
have a mutated HSP110 that makes it harder for proteins to properly fold.
This makes it harder for cancer cells to grow and divide, even killing some
of the cancerous cells, which leads to a smaller tumor volume in mutated
HSP110. In this sense, HSP110 is a safeguard against cancer. It helps cells
function normally. When HSP110 gets mutated (like in cancer), then it
won't function properly and sometimes lead to cell death, or at least
stunting growth.
Dominant because Xx and XX have basically the same effect
Question: Based on the passage, in MSI CRC primary tumor cells, the size of
the deletion in the HSP110 T17 microsatellite is inversely correlated with:
A.the amount of HSP110ΔE9 protein expressed.
B.the number of mature HSP110WT transcripts synthesized.
C.the frequency of the omission of HSP110 Exon 9 during splicing.
D.the extent of premature translation termination in Exon 10.
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Ans: Solution: The correct answer is B.
This is a Biology question that falls under the content category
"Transmission of genetic information from the gene to the protein." The
answer to this question is B. According to Table 1, as the size of the
deletion increases, the amount of HSP110ΔE9 and HSP110WT transcripts
synthesized increase and decrease, respectively. This is an inverse
relationship. This is a Data-based and Statistical Reasoning question as it
required interpretation of data in Table 1.
Question: A man with a CRC mutation that results in the synthesis of
HSP110ΔE9 and a woman that does not carry this mutation in any of her
tissues have a child. What is the percent chance that the child will inherit the
CRC mutation?
A.0%
B.25%
C.50%
D.100%
AAMC FL 1 Bio Questions with
Detailed Verified Answers
Question: Based on the data presented in the passage, which statement best
describes the HSP110ΔE9 allele?
A.Cancer-promoting and dominant to HSP110WT
B.Cancer-promoting and recessive to HSP110WT
C.Cancer-suppressing and dominant to HSP110WT
D.Cancer-suppressing and recessive to HSP110WT
, Page | 2
Ans: Solution: The correct answer is C.
This is a Biology question that falls under the content category
"Transmission of genetic information from the gene to the protein." The
answer to this question is C. According to Figure 1, as compared to
HSP110WT, HSP110ΔE9 slows tumor growth, and thus, it is cancer-
suppressing. According to the data in Table 2, HSP110ΔE9 counteracts the
ability of HSP110WT to prevent protein aggregation and prevent
apoptosis; thus, the HSP110ΔE9 allele is dominant to the HSP110WT
allele. This is a Data-based and Statistical Reasoning question as it
required interpretation of data in Figure 1 and Table 2.
Cancer causes rapid cell division, usually with some broken DNA repair
machinery. This causes tons of mutations within the genome. This is likely
how HSP110 gets mutated in the first place. There is probably a more
complicated mechanism behind this, but we don't get that information
from the passage.
, Page | 3
Normal HSP110 in a healthy cell helps protein folding. This helps the cell
grow and divide, among other things. Cancer cells want to grow and
divide, so they like to have normal HSP110. Unfortunately for them, they
have a mutated HSP110 that makes it harder for proteins to properly fold.
This makes it harder for cancer cells to grow and divide, even killing some
of the cancerous cells, which leads to a smaller tumor volume in mutated
HSP110. In this sense, HSP110 is a safeguard against cancer. It helps cells
function normally. When HSP110 gets mutated (like in cancer), then it
won't function properly and sometimes lead to cell death, or at least
stunting growth.
Dominant because Xx and XX have basically the same effect
Question: Based on the passage, in MSI CRC primary tumor cells, the size of
the deletion in the HSP110 T17 microsatellite is inversely correlated with:
A.the amount of HSP110ΔE9 protein expressed.
B.the number of mature HSP110WT transcripts synthesized.
C.the frequency of the omission of HSP110 Exon 9 during splicing.
D.the extent of premature translation termination in Exon 10.
, Page | 4
Ans: Solution: The correct answer is B.
This is a Biology question that falls under the content category
"Transmission of genetic information from the gene to the protein." The
answer to this question is B. According to Table 1, as the size of the
deletion increases, the amount of HSP110ΔE9 and HSP110WT transcripts
synthesized increase and decrease, respectively. This is an inverse
relationship. This is a Data-based and Statistical Reasoning question as it
required interpretation of data in Table 1.
Question: A man with a CRC mutation that results in the synthesis of
HSP110ΔE9 and a woman that does not carry this mutation in any of her
tissues have a child. What is the percent chance that the child will inherit the
CRC mutation?
A.0%
B.25%
C.50%
D.100%
