Registration of Shapes 1st Edition by Arunabha S
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, Deformable Density Matching for 3D Non-rigid
Registration of Shapes
Arunabha S. Roy1 , Ajay Gopinath1 , and Anand Rangarajan2,
1
Imaging Technologies Laboratory, GE Global Research Center, Bangalore, India
2
Department of CISE, University of Florida, Gainesville, FL, USA
Abstract. There exists a large body of literature on shape matching
and registration in medical image analysis. However, most of the previ-
ous work is focused on matching particular sets of features—point-sets,
lines, curves and surfaces. In this work, we forsake specific geometric
shape representations and instead seek probabilistic representations—
specifically Gaussian mixture models—of shapes. We evaluate a closed-
form distance between two probabilistic shape representations for the
general case where the mixture models differ in variance and the num-
ber of components. We then cast non-rigid registration as a deformable
density matching problem. In our approach, we take one mixture den-
sity onto another by deforming the component centroids via a thin-plate
spline (TPS) and also minimizing the distance with respect to the vari-
ance parameters. We validate our approach on synthetic and 3D arterial
tree data and evaluate it on 3D hippocampal shapes.
1 Introduction
The need for shape matching occurs in diverse sub-domains of medical image
analysis. Whenever a biomedical image is segmented or parsed into a set of
shapes, the need for shape analysis and comparison usually arises [1]. In brain
mapping for example [2], we frequently require the comparison of cortical and
subcortical structures such as the thalamus, putamen etc. extracted from subject
neuroanatomical MRI images. Image databases often use shape features and
here the need is to index and query the shape database. In MR angiography,
the complex network of blood vessels in the brain can be represented as trees or
graphs and need to be compared across subjects. And in cardiac applications, if
heart chamber information is available and extracted as a set of shapes, the wall
tracking problem requires us to solve for shape correspondences in the cardiac
cycle [3].
The need for shape matching is followed by a need for good shape repre-
sentations. When shape features are extracted from medical images, they can
be represented using an entire gamut of representations—points, line segments,
curves, surfaces, trees, graphs and hybrid representations. What should be noted
here is that an inferential stage is present in any shape representation. That is,
A.R. was partially supported by NSF IIS 0307712 and NIH RO1 NS046812.
N. Ayache, S. Ourselin, A. Maeder (Eds.): MICCAI 2007, Part I, LNCS 4791, pp. 942–949, 2007.
c Springer-Verlag Berlin Heidelberg 2007