1
CHAMBERLAIN NR507 MIDTERM EXAM NEWEST VERSION -
2025/2026- 100+ QUESTIONS AND VERIFIED ANSWERS 100%
CORRECT GUARANTEED SUCCESS
Autoimmunity
- Can be familial: Affected family members may not all develop the same disease,
but several members may have different disorders characterized by a variety of
hypersensitivity reactions (autoimmune and allergic reactions).
Alloimmunity
- General term used to describe when an individual's immune system reacts
against antigens on the tissues of other members of the same species.
- Examples: Neonatal disease where the maternal immune system becomes
sensitized against antigens expressed by the fetus, Transplant rejection,
Transfusion reaction.
Type 4 Hypersensitivity Reaction
- T-cell mediated
- Lymphocytes
- Does not involve antigen/antibody complexes
- Delayed response
- Ex: localized contact dermatitis. Treated with a topical corticosteroid (wouldn't
use antihistamine since Type 4 doesn't involve mast cells and H1 receptors).
Difference between type 2 & 3 hypersensitivity reactions
- Type 2: organ specific; antibody binds to the antigen on the cell surface.
, 2
- Type 3: not organ specific; antibody binds to soluble antigen outside the cell
surface that was released into the blood or body fluids, and the complex is then
deposited in the tissues.
Type 3 Hypersensitivity Reaction
- Immune complex
- Antigen-antibody complex deposited in the tissues
- Neutrophils are the primary effector cell
- Causes autoimmune diseases
- Examples: rheumatoid arthritis (joints), systemic lupus erythematosus (SLE,
organs)
Systemic Lupus Erythematosus (SLE)
- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia, leukopenia, lymphopenia,
thrombocytopenia)
- Immunologic disorders
- Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
Differentiating between the rash of a Type 1 vs Type 4 Reaction
CHAMBERLAIN NR507 MIDTERM EXAM NEWEST VERSION -
2025/2026- 100+ QUESTIONS AND VERIFIED ANSWERS 100%
CORRECT GUARANTEED SUCCESS
Autoimmunity
- Can be familial: Affected family members may not all develop the same disease,
but several members may have different disorders characterized by a variety of
hypersensitivity reactions (autoimmune and allergic reactions).
Alloimmunity
- General term used to describe when an individual's immune system reacts
against antigens on the tissues of other members of the same species.
- Examples: Neonatal disease where the maternal immune system becomes
sensitized against antigens expressed by the fetus, Transplant rejection,
Transfusion reaction.
Type 4 Hypersensitivity Reaction
- T-cell mediated
- Lymphocytes
- Does not involve antigen/antibody complexes
- Delayed response
- Ex: localized contact dermatitis. Treated with a topical corticosteroid (wouldn't
use antihistamine since Type 4 doesn't involve mast cells and H1 receptors).
Difference between type 2 & 3 hypersensitivity reactions
- Type 2: organ specific; antibody binds to the antigen on the cell surface.
, 2
- Type 3: not organ specific; antibody binds to soluble antigen outside the cell
surface that was released into the blood or body fluids, and the complex is then
deposited in the tissues.
Type 3 Hypersensitivity Reaction
- Immune complex
- Antigen-antibody complex deposited in the tissues
- Neutrophils are the primary effector cell
- Causes autoimmune diseases
- Examples: rheumatoid arthritis (joints), systemic lupus erythematosus (SLE,
organs)
Systemic Lupus Erythematosus (SLE)
- Facial rash confined to the cheeks (malar rash)
- Discoid rash (raised patches, scaling)
- Photosensitivity (skin rash d/t sunlight exposure)
- Oral or nasopharyngeal ulcers
- Hematologic disorders (hemolytic anemia, leukopenia, lymphopenia,
thrombocytopenia)
- Immunologic disorders
- Non-erosive arthritis of at least two peripheral joints
- Serositis (pleurisy, pericarditis)
- Renal disorder
- Neurologic disorders (seizures, psychosis)
- Presence of antinuclear antibody (ANA)
Differentiating between the rash of a Type 1 vs Type 4 Reaction
