Name: Score:
20 Multiple choice questions
Definition 1 of 20
Protein Binding (In Drug Distribution)
Drugs are excreted into the bile, but they are then reabsorbed by the small intestine and
returned to the liver. They are then metabolized again and then excreted in the urine.
Oral Drugs will never be 100% bioavailable because some portion of the drug will meet the
liver and be absorbed by the GI tract and metabolized by the liver.
Drugs will bind with proteins such as albumin, and become inactive and be stored for later
use. They become inactive because when the drug binds with the protein, it is too big to
squeeze through the capillaries, and enter the bloodstream, and act on cells.
Drugs that inhibit cell function by occupying receptor sites. This prevents natural body
substances or other drugs from occupying the cell receptor sites.
Definition 2 of 20
Hepatic Metabolism
Bio transformation or inactivation of drugs via the liver.
Metabolism.
Part of a drug is metabolized by the liver before it is able to reach systemic circulation to
reach the site of action.
Oral Drugs will never be 100% bioavailable because some portion of the drug will meet the
liver and be absorbed by the GI tract and metabolized by the liver.
, Term 3 of 20
Their livers and kidney's do not yet function so therefore they cannot metabolize the drugs and
excrete them.
Lipid-Membrane Solubility (Drug Pathway)
Why Can't Fetuses Eliminate Drugs From The Body?
What Is A Major Determinant of A Drug's Bio availability?
Result of The Blood-Brain Barrier In the CNS
Definition 4 of 20
Serum Half-Life
Should not be taken at the same time because they can cause severe hypertension or
intracranial hemorrhage.
The time required for a particular drug to decrease by 50%.
The amount of time that the drug actually works, or exerts it pharmacologic effects.
The amount of time it takes for a drug to reach MEC, or the minimal effective concentration.
Definition 5 of 20
Enterohepatic Recirculation
Same as regular diffusion, but drug molecules combine with a carrier substance such as a
protein or an enzyme. An example of this would be the carrier-protein facilitated
movement.
Transport of drug molecules within the body -- after a drug is injected and absorbed in the
bloodstream, it is carried to other sites via blood and tissue fluids.
Drug molecules move from areas of low concentration to areas of high concentration using
a carrier substance and the release of energy.
Drugs are excreted into the bile, but they are then reabsorbed by the small intestine and
returned to the liver. They are then metabolized again and then excreted in the urine.
20 Multiple choice questions
Definition 1 of 20
Protein Binding (In Drug Distribution)
Drugs are excreted into the bile, but they are then reabsorbed by the small intestine and
returned to the liver. They are then metabolized again and then excreted in the urine.
Oral Drugs will never be 100% bioavailable because some portion of the drug will meet the
liver and be absorbed by the GI tract and metabolized by the liver.
Drugs will bind with proteins such as albumin, and become inactive and be stored for later
use. They become inactive because when the drug binds with the protein, it is too big to
squeeze through the capillaries, and enter the bloodstream, and act on cells.
Drugs that inhibit cell function by occupying receptor sites. This prevents natural body
substances or other drugs from occupying the cell receptor sites.
Definition 2 of 20
Hepatic Metabolism
Bio transformation or inactivation of drugs via the liver.
Metabolism.
Part of a drug is metabolized by the liver before it is able to reach systemic circulation to
reach the site of action.
Oral Drugs will never be 100% bioavailable because some portion of the drug will meet the
liver and be absorbed by the GI tract and metabolized by the liver.
, Term 3 of 20
Their livers and kidney's do not yet function so therefore they cannot metabolize the drugs and
excrete them.
Lipid-Membrane Solubility (Drug Pathway)
Why Can't Fetuses Eliminate Drugs From The Body?
What Is A Major Determinant of A Drug's Bio availability?
Result of The Blood-Brain Barrier In the CNS
Definition 4 of 20
Serum Half-Life
Should not be taken at the same time because they can cause severe hypertension or
intracranial hemorrhage.
The time required for a particular drug to decrease by 50%.
The amount of time that the drug actually works, or exerts it pharmacologic effects.
The amount of time it takes for a drug to reach MEC, or the minimal effective concentration.
Definition 5 of 20
Enterohepatic Recirculation
Same as regular diffusion, but drug molecules combine with a carrier substance such as a
protein or an enzyme. An example of this would be the carrier-protein facilitated
movement.
Transport of drug molecules within the body -- after a drug is injected and absorbed in the
bloodstream, it is carried to other sites via blood and tissue fluids.
Drug molecules move from areas of low concentration to areas of high concentration using
a carrier substance and the release of energy.
Drugs are excreted into the bile, but they are then reabsorbed by the small intestine and
returned to the liver. They are then metabolized again and then excreted in the urine.
