ASCP Recalls – Clinical Laboratory Science – Practice Questions with
Answers for Certification Exam Review
FFP used for - correct answer Multiple coagulation deficiencies
Factor XI deficiency
Cryoprecipitate used for - correct answer Replace fibrinogen loss due to DIC
Massive bleeding
Dysfibrinogenemia with active bleeding
Plateletpheresis preparation steps - correct answer Light spin (remove RBC)
Heavy spin (spin down PLT and WBC)
Supernatant goes into bag for freezing (FFP)
Remaining plasma, platelets, and WBC = platelets
Irradiated blood prevents - correct answer GVHD
Also used for cancer patients, or patients who are immunocompromised
Leukocyte reduced blood prevents - correct answer Febrile nonhemolytic transfusion reactions
(FNHTRs)
Blood generally kept at what temperature? - correct answer 1-10C
Platelets and granulocytes kept at what temperature? - correct answer 20-24C
Platelets usually kept on agitator to ensure that the platelets are continuously oxygenated
,ACD, CPD, CPD2 expiration - correct answer 21 days
CPDA-1 expiration - correct answer 35 days
Rouleaux resolution - correct answer Saline wash and repeat
Common IgM antibodies in blood bank (Cold) - correct answer anti-I, H, M, N, P1, Lea, Leb
Common IgG antibodies in blood bank (Warm) - correct answer anti-D, C, c, E, e, M (some), K, k,
Fya, Fyb, Jka, Jkb
Antibodies enhanced by enzyme panel - correct answer RhIp Lewis the Kidd
Rh, I, Lea, Leb, Jka, Jkb
Overproduction of IgM associated with - correct answer Waldenstrom's Primary
Macroglobulinemia
Overproduction of IgG associated with - correct answer Multiple Myeloma
Serum calcitonin elevated in - correct answer Medullary carcinoma of thryroid
Normal myeloid:erythroid ratio - correct answer 2:1 to 4:1
Centromere ANA pattern - correct answer CREST syndrome
Homogeneous or speckled ANA pattern - correct answer SLE
Speckeled ANA pattern - correct answer RA or Sjorgen's
Measurement of sodium/chloride in sweat is useful test for - correct answer Cystic Fibrosis
Analytes increased due to delay in centrifugation - correct answer AST, ALT, Potassium,
Creatinine
Analytes decreased due to delay in centrifugation - correct answer Glucose, ionized calcium,
bicarbonate, folate
Reducing sugars include - correct answer Lactose, glucose, ribose
Incorporation of sulfamethoxazole and trimethoprim in culture media enhance recovery of -
correct answer Strep. pyogenes
Longer staining times associated with which type of smear - correct answer Bone marrow
smear
Dosage associated with homozygous or heterozygous cells - correct answer Homozygous
,Confirmatory test for syphilis - correct answer FTA-ABS (fluorescent treponemal antibody
absorption test)
VRDL and RPR are utilize which type of methodology - correct answer Flocculation
Mycobacterium species positive for nitrate reduction - correct answer Mycobacterium
tuberculosis
Measles (rubella), mumps, polio vaccine deferral time period - correct answer 2 weeks
Burkitt's lymphoma - correct answer 8:14 translocation; associated with EBV; "starry sky"
appearance on histology
Hodgkin Lymphoma (HL) - correct answer is a malignant lymphoma
Reed Sternberg cells are the hallmark of HL. Enlarged, painless lymph node in the neck (often
the first sign of HL).
A defective clot retraction might be caused by - correct answer Lack of defect of platelet
receptor IIb/IIIa
German measles vaccine deferral time period - correct answer 4 weeks
This protozoa can be routinely cultured - correct answer Acanthamoeba spp.
Aspirin prevent synthesis of - correct answer Thromboxane A2
Mycobacterium spp whose colonies are photochromogenic - correct answer Mycobacterium
kansaii
Burkholderia cepacia - correct answer GNB that is motile with polar tufts of flagella and
produces yellow pigment
Oxidase (+)
Pyocyanin (-)
Arginine dihydrolase (-)
Known to cause fulminating lung infections in CF patients
Burkholderia mallei - correct answer Glander's disease
, forms nodular lesions in the lung tissue and can cause ulcers leading to sepsis and death.
Clenched fist cellulitis associated with what organism - correct answer Eikenella corrodens
CEA tumor marker - correct answer colorectal cancer
Intestinal amebiasis symptoms - correct answer Abdominal cramps
Fever
Diarrhea
Bloody stool
Type of anemia where inability to incorporate iron into protoporphyrin ring - correct answer
Sideroblastic anemia
Immunoassay for hCG uses which subunit of hCG - correct answer Beta
Parasite typically comes from cat feces - correct answer Toxoplasma gondii
This condition made up of small clots made of platelets and large forms of VWF - correct
answer TTP (thrombotic thrombocytopenic purpura)
Normal heme contains - correct answer Four heme and four globin chains
Detection of MRSA - correct answer Zone of <10mm with an oxacillin disk on MH agar
Molecular tests for mecA gene
Drug of choice for Clostridium difficile and MRSA - correct answer Vancomycin (glycopeptide,
inhibit cell wall synthesis)
Drugs of choice for pseudomonas aeruginosa and other aerobes - correct answer Ciprofloxacin,
Norfloxacin (quinolines, inhibit nucleic acid synthesis)
Drug of choice for UTI, enteric infections - correct answer Sulfamethoxazole (Sulfonomides,
analogue of PABA)
Extended-spectrum beta-lactamases - correct answer Enzymes that give bacteria immunity to
both penicillin and cephalosporin antibiotics
Tiny GN coccobacilli associated with wild boar - correct answer Brucella spp.
This condition is associated with oligoclonal band in CSF electrophoresis - correct answer
Multiple sclerosis
Cell indicative of kidney disease - correct answer Tubular epithelial cells
Answers for Certification Exam Review
FFP used for - correct answer Multiple coagulation deficiencies
Factor XI deficiency
Cryoprecipitate used for - correct answer Replace fibrinogen loss due to DIC
Massive bleeding
Dysfibrinogenemia with active bleeding
Plateletpheresis preparation steps - correct answer Light spin (remove RBC)
Heavy spin (spin down PLT and WBC)
Supernatant goes into bag for freezing (FFP)
Remaining plasma, platelets, and WBC = platelets
Irradiated blood prevents - correct answer GVHD
Also used for cancer patients, or patients who are immunocompromised
Leukocyte reduced blood prevents - correct answer Febrile nonhemolytic transfusion reactions
(FNHTRs)
Blood generally kept at what temperature? - correct answer 1-10C
Platelets and granulocytes kept at what temperature? - correct answer 20-24C
Platelets usually kept on agitator to ensure that the platelets are continuously oxygenated
,ACD, CPD, CPD2 expiration - correct answer 21 days
CPDA-1 expiration - correct answer 35 days
Rouleaux resolution - correct answer Saline wash and repeat
Common IgM antibodies in blood bank (Cold) - correct answer anti-I, H, M, N, P1, Lea, Leb
Common IgG antibodies in blood bank (Warm) - correct answer anti-D, C, c, E, e, M (some), K, k,
Fya, Fyb, Jka, Jkb
Antibodies enhanced by enzyme panel - correct answer RhIp Lewis the Kidd
Rh, I, Lea, Leb, Jka, Jkb
Overproduction of IgM associated with - correct answer Waldenstrom's Primary
Macroglobulinemia
Overproduction of IgG associated with - correct answer Multiple Myeloma
Serum calcitonin elevated in - correct answer Medullary carcinoma of thryroid
Normal myeloid:erythroid ratio - correct answer 2:1 to 4:1
Centromere ANA pattern - correct answer CREST syndrome
Homogeneous or speckled ANA pattern - correct answer SLE
Speckeled ANA pattern - correct answer RA or Sjorgen's
Measurement of sodium/chloride in sweat is useful test for - correct answer Cystic Fibrosis
Analytes increased due to delay in centrifugation - correct answer AST, ALT, Potassium,
Creatinine
Analytes decreased due to delay in centrifugation - correct answer Glucose, ionized calcium,
bicarbonate, folate
Reducing sugars include - correct answer Lactose, glucose, ribose
Incorporation of sulfamethoxazole and trimethoprim in culture media enhance recovery of -
correct answer Strep. pyogenes
Longer staining times associated with which type of smear - correct answer Bone marrow
smear
Dosage associated with homozygous or heterozygous cells - correct answer Homozygous
,Confirmatory test for syphilis - correct answer FTA-ABS (fluorescent treponemal antibody
absorption test)
VRDL and RPR are utilize which type of methodology - correct answer Flocculation
Mycobacterium species positive for nitrate reduction - correct answer Mycobacterium
tuberculosis
Measles (rubella), mumps, polio vaccine deferral time period - correct answer 2 weeks
Burkitt's lymphoma - correct answer 8:14 translocation; associated with EBV; "starry sky"
appearance on histology
Hodgkin Lymphoma (HL) - correct answer is a malignant lymphoma
Reed Sternberg cells are the hallmark of HL. Enlarged, painless lymph node in the neck (often
the first sign of HL).
A defective clot retraction might be caused by - correct answer Lack of defect of platelet
receptor IIb/IIIa
German measles vaccine deferral time period - correct answer 4 weeks
This protozoa can be routinely cultured - correct answer Acanthamoeba spp.
Aspirin prevent synthesis of - correct answer Thromboxane A2
Mycobacterium spp whose colonies are photochromogenic - correct answer Mycobacterium
kansaii
Burkholderia cepacia - correct answer GNB that is motile with polar tufts of flagella and
produces yellow pigment
Oxidase (+)
Pyocyanin (-)
Arginine dihydrolase (-)
Known to cause fulminating lung infections in CF patients
Burkholderia mallei - correct answer Glander's disease
, forms nodular lesions in the lung tissue and can cause ulcers leading to sepsis and death.
Clenched fist cellulitis associated with what organism - correct answer Eikenella corrodens
CEA tumor marker - correct answer colorectal cancer
Intestinal amebiasis symptoms - correct answer Abdominal cramps
Fever
Diarrhea
Bloody stool
Type of anemia where inability to incorporate iron into protoporphyrin ring - correct answer
Sideroblastic anemia
Immunoassay for hCG uses which subunit of hCG - correct answer Beta
Parasite typically comes from cat feces - correct answer Toxoplasma gondii
This condition made up of small clots made of platelets and large forms of VWF - correct
answer TTP (thrombotic thrombocytopenic purpura)
Normal heme contains - correct answer Four heme and four globin chains
Detection of MRSA - correct answer Zone of <10mm with an oxacillin disk on MH agar
Molecular tests for mecA gene
Drug of choice for Clostridium difficile and MRSA - correct answer Vancomycin (glycopeptide,
inhibit cell wall synthesis)
Drugs of choice for pseudomonas aeruginosa and other aerobes - correct answer Ciprofloxacin,
Norfloxacin (quinolines, inhibit nucleic acid synthesis)
Drug of choice for UTI, enteric infections - correct answer Sulfamethoxazole (Sulfonomides,
analogue of PABA)
Extended-spectrum beta-lactamases - correct answer Enzymes that give bacteria immunity to
both penicillin and cephalosporin antibiotics
Tiny GN coccobacilli associated with wild boar - correct answer Brucella spp.
This condition is associated with oligoclonal band in CSF electrophoresis - correct answer
Multiple sclerosis
Cell indicative of kidney disease - correct answer Tubular epithelial cells
