NR 507 Midterm Verified Multiple Choice and
Conceptual Actual Emended Exam Questions
With Reviewed 100% Correct Detailed Answers
Guaranteed Pass!!Current Update
Q1. Which type of anemia is associated with small red blood cells and decreased
hemoglobin synthesis?
A) Macrocytic anemia
B) Microcytic anemia
C) Normocytic anemia
D) Hemolytic anemia
Answer: B
Rationale: Thalassemia is a microcytic anemia, producing small RBCs due to
impaired globin chain synthesis.
Q2. A client with beta-thalassemia major receives frequent transfusions. Which
complication should the NP monitor most closely?
A) Vitamin B12 deficiency
B) Iron overload
C) Leukopenia
D) Vitamin D deficiency
Answer: B
Rationale: Repeated transfusions → iron overload → requires chelation therapy.
Q3. Which medications are used in chelation therapy for thalassemia?
A) Methotrexate and folic acid
B) Deferasirox and deferiprone
,C) Iron supplements
D) Erythropoietin
Answer: B
Rationale: Deferasirox & deferiprone remove excess iron from transfusions.
Q4. Which definitive treatment is available for some patients with thalassemia
major?
A) Long-term folate supplementation
B) Bone marrow transplant
C) High-dose steroids
D) Radiation therapy
Answer: B
Rationale: Bone marrow transplant can cure severe thalassemia.
Q5. Which client is most at risk for Vitamin B12 deficiency anemia?
A) A vegetarian who eats dairy
B) An adult who had a sleeve gastrectomy
C) A client with mild hypertension
D) An adolescent with acne
Answer: B
Rationale: Gastrectomy reduces intrinsic factor → impaired B12 absorption.
Q6. What neurological finding is common in Vitamin B12 deficiency but not in
folate deficiency?
A) Peripheral neuropathy
B) Glossitis
C) Fatigue
D) Pallor
,Answer: A
Rationale: B12 deficiency causes neurological damage; folate deficiency does not.
Q7. A patient with B12 deficiency is being treated. Which lab finding indicates
effective therapy?
A) Decreased hemoglobin
B) Normalized MCV
C) Decreased ferritin
D) Reduced bilirubin
Answer: B
Rationale: Macrocytic anemia (↑MCV) normalizes as treatment works.
Q8. Which medications impair B12 absorption?
A) Metformin and PPIs
B) NSAIDs and aspirin
C) Statins and beta blockers
D) SSRIs and SNRIs
Answer: A
Rationale: Metformin, H2 blockers, and PPIs reduce B12 absorption.
Q9. Which group is most at risk for folate deficiency?
A) A 27-year-old pregnant woman
B) A healthy adolescent male
C) A 50-year-old vegetarian eating leafy greens
D) A middle-aged athlete on a high-protein diet
Answer: A
Rationale: Pregnancy increases folate needs; deficiency is common if diet is
inadequate.
, Q10. Which medications reduce folate absorption?
A) Anticonvulsants and methotrexate
B) Beta blockers
C) SSRIs
D) Calcium channel blockers
Answer: A
Rationale: Methotrexate and some anticonvulsants interfere with folate
metabolism.
Q11. Which symptom is more typical in folate deficiency anemia than B12
deficiency?
A) Neuropathy
B) Sore tongue (glossitis) without neurological deficits
C) Ataxia
D) Cognitive decline
Answer: B
Rationale: Folate deficiency → glossitis; no neurologic changes like in B12
deficiency.
Q12. The primary mechanism of anemia of chronic disease is:
A) Increased blood loss
B) Defective erythropoiesis due to inflammatory cytokines
C) Vitamin B12 deficiency
D) Excess iron absorption
Answer: B
Rationale: Inflammatory mediators impair iron use and erythropoietin production.
Q13. Which lab finding is typical of anemia of chronic disease?
A) Elevated reticulocytes
Conceptual Actual Emended Exam Questions
With Reviewed 100% Correct Detailed Answers
Guaranteed Pass!!Current Update
Q1. Which type of anemia is associated with small red blood cells and decreased
hemoglobin synthesis?
A) Macrocytic anemia
B) Microcytic anemia
C) Normocytic anemia
D) Hemolytic anemia
Answer: B
Rationale: Thalassemia is a microcytic anemia, producing small RBCs due to
impaired globin chain synthesis.
Q2. A client with beta-thalassemia major receives frequent transfusions. Which
complication should the NP monitor most closely?
A) Vitamin B12 deficiency
B) Iron overload
C) Leukopenia
D) Vitamin D deficiency
Answer: B
Rationale: Repeated transfusions → iron overload → requires chelation therapy.
Q3. Which medications are used in chelation therapy for thalassemia?
A) Methotrexate and folic acid
B) Deferasirox and deferiprone
,C) Iron supplements
D) Erythropoietin
Answer: B
Rationale: Deferasirox & deferiprone remove excess iron from transfusions.
Q4. Which definitive treatment is available for some patients with thalassemia
major?
A) Long-term folate supplementation
B) Bone marrow transplant
C) High-dose steroids
D) Radiation therapy
Answer: B
Rationale: Bone marrow transplant can cure severe thalassemia.
Q5. Which client is most at risk for Vitamin B12 deficiency anemia?
A) A vegetarian who eats dairy
B) An adult who had a sleeve gastrectomy
C) A client with mild hypertension
D) An adolescent with acne
Answer: B
Rationale: Gastrectomy reduces intrinsic factor → impaired B12 absorption.
Q6. What neurological finding is common in Vitamin B12 deficiency but not in
folate deficiency?
A) Peripheral neuropathy
B) Glossitis
C) Fatigue
D) Pallor
,Answer: A
Rationale: B12 deficiency causes neurological damage; folate deficiency does not.
Q7. A patient with B12 deficiency is being treated. Which lab finding indicates
effective therapy?
A) Decreased hemoglobin
B) Normalized MCV
C) Decreased ferritin
D) Reduced bilirubin
Answer: B
Rationale: Macrocytic anemia (↑MCV) normalizes as treatment works.
Q8. Which medications impair B12 absorption?
A) Metformin and PPIs
B) NSAIDs and aspirin
C) Statins and beta blockers
D) SSRIs and SNRIs
Answer: A
Rationale: Metformin, H2 blockers, and PPIs reduce B12 absorption.
Q9. Which group is most at risk for folate deficiency?
A) A 27-year-old pregnant woman
B) A healthy adolescent male
C) A 50-year-old vegetarian eating leafy greens
D) A middle-aged athlete on a high-protein diet
Answer: A
Rationale: Pregnancy increases folate needs; deficiency is common if diet is
inadequate.
, Q10. Which medications reduce folate absorption?
A) Anticonvulsants and methotrexate
B) Beta blockers
C) SSRIs
D) Calcium channel blockers
Answer: A
Rationale: Methotrexate and some anticonvulsants interfere with folate
metabolism.
Q11. Which symptom is more typical in folate deficiency anemia than B12
deficiency?
A) Neuropathy
B) Sore tongue (glossitis) without neurological deficits
C) Ataxia
D) Cognitive decline
Answer: B
Rationale: Folate deficiency → glossitis; no neurologic changes like in B12
deficiency.
Q12. The primary mechanism of anemia of chronic disease is:
A) Increased blood loss
B) Defective erythropoiesis due to inflammatory cytokines
C) Vitamin B12 deficiency
D) Excess iron absorption
Answer: B
Rationale: Inflammatory mediators impair iron use and erythropoietin production.
Q13. Which lab finding is typical of anemia of chronic disease?
A) Elevated reticulocytes
