COMSAE Verified Multiple Choice and
Conceptual Actual Emended Exam Questions
With Reviewed 100% Correct Detailed Answers
Guaranteed Pass!!Current Update
1. A 24-year-old woman presents with excessive daytime sleepiness. She
experiences sudden muscle weakness triggered by laughter. Best initial
treatment?
A) Benzodiazepines
B) Modafinil
C) SSRIs
D) Haloperidol
Answer: B
Rationale: Narcolepsy → modafinil (wake-promoting agent).
Q2. A 54-year-old man with cirrhosis presents with hematemesis. Endoscopy
confirms esophageal variceal bleeding. Best pharmacologic therapy?
A) Propranolol
B) Octreotide
C) Furosemide
D) Nifedipine
Answer: B
Rationale: Octreotide (somatostatin analog) decreases splanchnic blood flow.
Q3. A 29-year-old obese woman presents with headaches and papilledema.
Diagnosis: idiopathic intracranial hypertension. Drug of choice?
,A) Acetazolamide
B) Prednisone
C) Furosemide
D) Topiramate
Answer: A
Rationale: Carbonic anhydrase inhibitor ↓CSF production.
Q4. A woman suddenly develops hypotension, dyspnea, and seizures during labor.
Central venous pressure is elevated; PCWP is low. Diagnosis?
A) Pulmonary embolism
B) Amniotic fluid embolism
C) MI
D) Sepsis
Answer: B
Rationale: Amniotic fluid embolism → obstructive shock + respiratory failure.
Q5. A patient with severe dyspnea. Histology: alveolar hyaline membranes. Most
likely diagnosis?
A) ARDS
B) COPD
C) Asthma
D) TB
Answer: A
Rationale: Hyaline membranes = hallmark of ARDS.
Q6. UV light exposure causes DNA damage by producing:
A) Guanine oxidation
B) Purine crosslinks
C) Pyrimidine dimers
D) Telomere shortening
,Answer: C
Rationale: UV → thymine dimers repaired by nucleotide excision repair.
Q7. Rapidly dividing tumor cells often rely on anaerobic glycolysis, leading to
accumulation of:
A) Ketones
B) Lactate
C) Acetyl-CoA
D) Uric acid
Answer: B
Rationale: Cancer cells → Warburg effect → lactate production.
Q8. The BCL2 protein functions by:
A) Stimulating caspase activation
B) Inhibiting cytochrome C release
C) Activating TNF receptors
D) Stabilizing p53
Answer: B
Rationale: BCL2 blocks apoptosis by preventing cytochrome C release.
Q9. BCL2 overexpression due to t(14;18) translocation is seen in:
A) Burkitt lymphoma
B) Follicular lymphoma
C) Hodgkin lymphoma
D) CML
Answer: B
Rationale: Classic follicular lymphoma translocation.
, Q10. Cytochrome C, once released from mitochondria, functions as a:
A) DNA repair enzyme
B) Pro-apoptotic factor activating caspases
C) Protein synthesis regulator
D) Antioxidant
Answer: B
Rationale: Cytochrome C → caspase cascade → apoptosis.
Q11. A trauma patient with distended neck veins, hypotension, and absent breath
sounds on left. Immediate treatment?
A) Chest X-ray
B) Needle decompression
C) Intubation
D) Pericardiocentesis
Answer: B
Rationale: Tension pneumothorax → decompress before confirmatory imaging.
Q12. A 26-year-old with sudden right-sided chest pain while jogging. Exam:
hyperresonant percussion note, decreased breath sounds, trachea midline.
Diagnosis?
A) Pleural effusion
B) Spontaneous pneumothorax
C) Tension pneumothorax
D) Asthma exacerbation
Answer: B
Rationale: Tall thin young adult → spontaneous pneumothorax.
Q13. A 60-year-old with chest pain. EKG: Q waves in II, III, aVF. Which artery is
involved?
A) LAD
Conceptual Actual Emended Exam Questions
With Reviewed 100% Correct Detailed Answers
Guaranteed Pass!!Current Update
1. A 24-year-old woman presents with excessive daytime sleepiness. She
experiences sudden muscle weakness triggered by laughter. Best initial
treatment?
A) Benzodiazepines
B) Modafinil
C) SSRIs
D) Haloperidol
Answer: B
Rationale: Narcolepsy → modafinil (wake-promoting agent).
Q2. A 54-year-old man with cirrhosis presents with hematemesis. Endoscopy
confirms esophageal variceal bleeding. Best pharmacologic therapy?
A) Propranolol
B) Octreotide
C) Furosemide
D) Nifedipine
Answer: B
Rationale: Octreotide (somatostatin analog) decreases splanchnic blood flow.
Q3. A 29-year-old obese woman presents with headaches and papilledema.
Diagnosis: idiopathic intracranial hypertension. Drug of choice?
,A) Acetazolamide
B) Prednisone
C) Furosemide
D) Topiramate
Answer: A
Rationale: Carbonic anhydrase inhibitor ↓CSF production.
Q4. A woman suddenly develops hypotension, dyspnea, and seizures during labor.
Central venous pressure is elevated; PCWP is low. Diagnosis?
A) Pulmonary embolism
B) Amniotic fluid embolism
C) MI
D) Sepsis
Answer: B
Rationale: Amniotic fluid embolism → obstructive shock + respiratory failure.
Q5. A patient with severe dyspnea. Histology: alveolar hyaline membranes. Most
likely diagnosis?
A) ARDS
B) COPD
C) Asthma
D) TB
Answer: A
Rationale: Hyaline membranes = hallmark of ARDS.
Q6. UV light exposure causes DNA damage by producing:
A) Guanine oxidation
B) Purine crosslinks
C) Pyrimidine dimers
D) Telomere shortening
,Answer: C
Rationale: UV → thymine dimers repaired by nucleotide excision repair.
Q7. Rapidly dividing tumor cells often rely on anaerobic glycolysis, leading to
accumulation of:
A) Ketones
B) Lactate
C) Acetyl-CoA
D) Uric acid
Answer: B
Rationale: Cancer cells → Warburg effect → lactate production.
Q8. The BCL2 protein functions by:
A) Stimulating caspase activation
B) Inhibiting cytochrome C release
C) Activating TNF receptors
D) Stabilizing p53
Answer: B
Rationale: BCL2 blocks apoptosis by preventing cytochrome C release.
Q9. BCL2 overexpression due to t(14;18) translocation is seen in:
A) Burkitt lymphoma
B) Follicular lymphoma
C) Hodgkin lymphoma
D) CML
Answer: B
Rationale: Classic follicular lymphoma translocation.
, Q10. Cytochrome C, once released from mitochondria, functions as a:
A) DNA repair enzyme
B) Pro-apoptotic factor activating caspases
C) Protein synthesis regulator
D) Antioxidant
Answer: B
Rationale: Cytochrome C → caspase cascade → apoptosis.
Q11. A trauma patient with distended neck veins, hypotension, and absent breath
sounds on left. Immediate treatment?
A) Chest X-ray
B) Needle decompression
C) Intubation
D) Pericardiocentesis
Answer: B
Rationale: Tension pneumothorax → decompress before confirmatory imaging.
Q12. A 26-year-old with sudden right-sided chest pain while jogging. Exam:
hyperresonant percussion note, decreased breath sounds, trachea midline.
Diagnosis?
A) Pleural effusion
B) Spontaneous pneumothorax
C) Tension pneumothorax
D) Asthma exacerbation
Answer: B
Rationale: Tall thin young adult → spontaneous pneumothorax.
Q13. A 60-year-old with chest pain. EKG: Q waves in II, III, aVF. Which artery is
involved?
A) LAD
