, Solution manua for Biochemistry, 7th Edition
Reginald H. Garrett
Notes
1- All Chapters are step by step.
2- We have shown you 10 pages.
3- The file contains all Appendix and Excel
sheet if it exists.
4- We have all what you need, we make
update at every time. There are many new
editions waiting you.
5- If you think you purchased the wrong file
You can contact us at every time, we can
replace it with true one.
Our email:
, Instructor Solutions Manual, Study
Guide, and Problems Book
Biochemistry,
7th Edition
Reginald H. Garrett
University of Virginia
Charles M. Grisham
University of Virginia
Australia • Brazil • Canada • Mexico • Singapore • United Kingdom • United States
Garrett & Grisham FM-1
,© 2024 Cengage Learning, Inc. ALL RIGHTS RESERVED.
WCN: 01-100-101
No part of this work covered by the copyright herein may be reproduced or distributed in
any form or by any means, except as permitted by U.S. copyright law, without the prior
written permission of the copyright owner.
For product information and technology assistance, contact us at
Cengage Customer & Sales Support, 1-800-354-9706
or support.cengage.com.
For permission to use material from this text or product, submit all
requests online at www.copyright.com.
ISBN: 978-0-357-72848-2
Cengage
200 Pier 4 Boulevard
Boston, MA 02210
USA
Cengage is a leading provider of customized learning solutions with employees residing
in nearly 40 different countries and sales in more than 125 countries around the world.
Find your local representative at: www.cengage.com.
To learn more about Cengage platforms and services, register or access your online
learning solution, or purchase materials for your course, visit www.cengage.com.
Printed in the United States of America
Print Number: 02 Print Year: 2024
Garrett & Grisham FM-2
,Table of Contents
Preface
Chapter 1 - The Facts of Life: Chemistry Is the Logic of Biological Phenomena
Chapter 2 - Water: The Medium of Life
Chapter 3 - Thermodynamics of Biological Systems
Chapter 4 - Amino Acids and the Peptide Bond
Chapter 5 - Proteins: Their Primary Structure and Biological Functions
Chapter 6 - Proteins: Secondary, Tertiary, and Quaternary Structure
Chapter 7 - Carbohydrates and the Glycoconjugates of Cell Surfaces
Chapter 8 - Lipids
Chapter 9 - Membranes and Membrane Transport
Chapter 10 - Nucleotides and Nucleic Acids
Chapter 11 - Structure of Nucleic Acids
Chapter 12 - Recombinant DNA: Cloning, Chimeric Genes, and Synthetic Biology
Chapter 13 - Enzymes—Kinetics and Specificity
Chapter 14 - Mechanisms of Enzyme Action
Chapter 15 - Enzyme Regulation
Chapter 16 - Molecular Motors
Chapter 17 - Metabolism: An Overview
Chapter 18 - Glycolysis
Chapter 19 - The Tricarboxylic Acid Cycle
Chapter 20 - Electron Transport and Oxidative Phosphorylation
Chapter 21 - Photosynthesis
Garrett & Grisham FM-3
,Chapter 22 - Gluconeogenesis, Glycogen Metabolism, and the Pentose
Phosphate Pathway
Chapter 23 - Fatty Acid Catabolism
Chapter 24 - Lipid Biosynthesis
Chapter 25 - Nitrogen Acquisition and Amino Acid Metabolism
Chapter 26 - Synthesis and Degradation of Nucleotides
Chapter 27 - Metabolic Integration and Organ Specialization
Chapter 28 - DNA Metabolism: Replication, Recombination, and Repair
Chapter 29 - Transcription and the Regulation of Gene Expression
Chapter 30 - Protein Synthesis
Chapter 31 - Completing the Protein Life Cycle: Folding, Processing, and Degradation
Chapter 32 - The Reception and Transmission of Extracellular Information
Glossary
Garrett & Grisham FM-4
,Preface
In one scene in the movie Stripes (Columbia Picture Corporation 1981), privates John
Winger and Russell Zissky (played by Bill Murray and Harold Ramis) attempt to
persuade their platoon to an all night training session to prepare for the next day’s final
parade. The troops are skeptical of the plan; however, Zissky wins them over by his
testimony of the importance of cramming. He proudly reports that he had, in fact, once
learned two semesters of geology in a single three-hour all-nighter.
It would seem unlikely that this approach would work well with biochemistry (or
even geology). Rather a steady diet of reading, problem solving, and reviewing might be
a better plan of attack. This study guide was written to accompany “Biochemistry” by
Garrett and Grisham. It includes chapter outlines, guides to key points covered in the
chapters, in-depth solutions to the problems presented in the textbook, additional
problems, and detailed summaries of each chapter. In addition, there is a glossary of
biochemical terms and key text figures.
Several years ago I spent part of a sabbatical in Italy and in preparation took a year-
long course in elementary Italian. I had not been on the student-end of an academic
interaction for several years and taking a language course was an excellent opportunity to
be reminded of the difficulties of learning something for the first time. Memorization is
part and parcel to the study of any language and so I found myself committing to memory
nouns, verbs, adverbs, adjectives, and complex, irregular verb conjugations. The study of
biochemistry has parallels to language studies in that memorization is necessary. What
makes the study of biochemistry somewhat easier, however, are the common themes, the
interconnections between various facets of biochemistry, and the biological and chemical
principles at work. The authors have done a marvelous job in presenting these aspects of
biochemistry and I have attempted to highlight them here. Biochemistry is a demanding
discipline but one well worth the effort for any student of the sciences. Buona fortuna.
Garrett & Grisham FM-5
, Why Study Biochemistry?
This excerpt from Poetry and Science by the Scottish poet Hugh MacDiarmid (1892–
1978), which first appeared in Lucky Poet (1943), might help with an answer.
Poetry and Science
Wherefore I seek a poetry of facts. Even as The profound kinship of all living substance
Is made clear by the chemical route.
Without some chemistry one is bound to remain Forever a dumbfounded savage In the
face of vital reactions. The beautiful relations Shown only by biochemistry
Replace a stupefied sense of wonder With something more wonderful Because natural
and understandable. Nature is more wonderful
When it is at least partly understood. Such
an understanding dawns
On the lay reader when he becomes
Acquainted with the biochemistry of the glands
In their relation to diseases such as goitre
And their effects on growth, sex, and reproduction. He will
begin to comprehend a little
The subtlety and beauty of the action
Of enzymes, viruses, and bacteriophages, These
substances which are on the borderland Between the
living and the non-living.
He will understand why the biochemist
Can speculate on the possibility
Of the synthesis of life without feeling
That thereby he is shallow or blasphemous. He will
understand that, on the contrary, He finds all the
more
Because he seeks for the endless
—’Even our deepest emotions
May be conditioned by traces
Of a derivative of phenanthrene!’
Science is the Differential
Calculus of the mind,
Art is the Integral Calculus;
they may be Beautiful apart, but are
great only when combined.
Sir Ronald Ross
Garrett & Grisham FM-6
,In this poem, MacDiarmid argues strongly for the importance of studying biochemistry to
understand and appreciate Nature itself. The poem was published in 1943, well before the
molecular revolution in biochemistry, well before the first protein structure was solved or
the first gene cloned yet MacDiarmid seems to have appreciated the importance of
enzyme kinetics and enzyme catalysis and to anticipate the value of recombinant DNA
technology: “The subtlety and beauty of the action of enzymes, viruses, and
bacteriophages.…” He even suggests that a fundamental understanding of life itself might
be possible through biochemistry.
It is interesting to see how biochemists are portrayed in movies and films in this
electronic age. In the 1996 film The Rock staring Sean Connery and Nicholas Cage, Cage
plays a biochemist enlisted by the FBI to deal with a threat involving VX gas warheads.
(VX is a potent acetylcholinesterase inhibitor.) Cage’s character, Stanley Goodspeed,
delivers this memorable line, which informs the audience of his expertise: “Look, I’m
just a biochemist. Most of the time, I work in a little glass jar and lead a very uneventful
life. I drive a Volvo, a beige one. But what I’m dealing with here is one of the most
deadly substances the earth has ever known, so what say you cut me some friggin’
slack!” Perhaps Stanley is overstating the danger inherent in his work but he is surely
understating the importance of his occupation.
Garrett & Grisham FM-7
,
Reginald H. Garrett
Notes
1- All Chapters are step by step.
2- We have shown you 10 pages.
3- The file contains all Appendix and Excel
sheet if it exists.
4- We have all what you need, we make
update at every time. There are many new
editions waiting you.
5- If you think you purchased the wrong file
You can contact us at every time, we can
replace it with true one.
Our email:
, Instructor Solutions Manual, Study
Guide, and Problems Book
Biochemistry,
7th Edition
Reginald H. Garrett
University of Virginia
Charles M. Grisham
University of Virginia
Australia • Brazil • Canada • Mexico • Singapore • United Kingdom • United States
Garrett & Grisham FM-1
,© 2024 Cengage Learning, Inc. ALL RIGHTS RESERVED.
WCN: 01-100-101
No part of this work covered by the copyright herein may be reproduced or distributed in
any form or by any means, except as permitted by U.S. copyright law, without the prior
written permission of the copyright owner.
For product information and technology assistance, contact us at
Cengage Customer & Sales Support, 1-800-354-9706
or support.cengage.com.
For permission to use material from this text or product, submit all
requests online at www.copyright.com.
ISBN: 978-0-357-72848-2
Cengage
200 Pier 4 Boulevard
Boston, MA 02210
USA
Cengage is a leading provider of customized learning solutions with employees residing
in nearly 40 different countries and sales in more than 125 countries around the world.
Find your local representative at: www.cengage.com.
To learn more about Cengage platforms and services, register or access your online
learning solution, or purchase materials for your course, visit www.cengage.com.
Printed in the United States of America
Print Number: 02 Print Year: 2024
Garrett & Grisham FM-2
,Table of Contents
Preface
Chapter 1 - The Facts of Life: Chemistry Is the Logic of Biological Phenomena
Chapter 2 - Water: The Medium of Life
Chapter 3 - Thermodynamics of Biological Systems
Chapter 4 - Amino Acids and the Peptide Bond
Chapter 5 - Proteins: Their Primary Structure and Biological Functions
Chapter 6 - Proteins: Secondary, Tertiary, and Quaternary Structure
Chapter 7 - Carbohydrates and the Glycoconjugates of Cell Surfaces
Chapter 8 - Lipids
Chapter 9 - Membranes and Membrane Transport
Chapter 10 - Nucleotides and Nucleic Acids
Chapter 11 - Structure of Nucleic Acids
Chapter 12 - Recombinant DNA: Cloning, Chimeric Genes, and Synthetic Biology
Chapter 13 - Enzymes—Kinetics and Specificity
Chapter 14 - Mechanisms of Enzyme Action
Chapter 15 - Enzyme Regulation
Chapter 16 - Molecular Motors
Chapter 17 - Metabolism: An Overview
Chapter 18 - Glycolysis
Chapter 19 - The Tricarboxylic Acid Cycle
Chapter 20 - Electron Transport and Oxidative Phosphorylation
Chapter 21 - Photosynthesis
Garrett & Grisham FM-3
,Chapter 22 - Gluconeogenesis, Glycogen Metabolism, and the Pentose
Phosphate Pathway
Chapter 23 - Fatty Acid Catabolism
Chapter 24 - Lipid Biosynthesis
Chapter 25 - Nitrogen Acquisition and Amino Acid Metabolism
Chapter 26 - Synthesis and Degradation of Nucleotides
Chapter 27 - Metabolic Integration and Organ Specialization
Chapter 28 - DNA Metabolism: Replication, Recombination, and Repair
Chapter 29 - Transcription and the Regulation of Gene Expression
Chapter 30 - Protein Synthesis
Chapter 31 - Completing the Protein Life Cycle: Folding, Processing, and Degradation
Chapter 32 - The Reception and Transmission of Extracellular Information
Glossary
Garrett & Grisham FM-4
,Preface
In one scene in the movie Stripes (Columbia Picture Corporation 1981), privates John
Winger and Russell Zissky (played by Bill Murray and Harold Ramis) attempt to
persuade their platoon to an all night training session to prepare for the next day’s final
parade. The troops are skeptical of the plan; however, Zissky wins them over by his
testimony of the importance of cramming. He proudly reports that he had, in fact, once
learned two semesters of geology in a single three-hour all-nighter.
It would seem unlikely that this approach would work well with biochemistry (or
even geology). Rather a steady diet of reading, problem solving, and reviewing might be
a better plan of attack. This study guide was written to accompany “Biochemistry” by
Garrett and Grisham. It includes chapter outlines, guides to key points covered in the
chapters, in-depth solutions to the problems presented in the textbook, additional
problems, and detailed summaries of each chapter. In addition, there is a glossary of
biochemical terms and key text figures.
Several years ago I spent part of a sabbatical in Italy and in preparation took a year-
long course in elementary Italian. I had not been on the student-end of an academic
interaction for several years and taking a language course was an excellent opportunity to
be reminded of the difficulties of learning something for the first time. Memorization is
part and parcel to the study of any language and so I found myself committing to memory
nouns, verbs, adverbs, adjectives, and complex, irregular verb conjugations. The study of
biochemistry has parallels to language studies in that memorization is necessary. What
makes the study of biochemistry somewhat easier, however, are the common themes, the
interconnections between various facets of biochemistry, and the biological and chemical
principles at work. The authors have done a marvelous job in presenting these aspects of
biochemistry and I have attempted to highlight them here. Biochemistry is a demanding
discipline but one well worth the effort for any student of the sciences. Buona fortuna.
Garrett & Grisham FM-5
, Why Study Biochemistry?
This excerpt from Poetry and Science by the Scottish poet Hugh MacDiarmid (1892–
1978), which first appeared in Lucky Poet (1943), might help with an answer.
Poetry and Science
Wherefore I seek a poetry of facts. Even as The profound kinship of all living substance
Is made clear by the chemical route.
Without some chemistry one is bound to remain Forever a dumbfounded savage In the
face of vital reactions. The beautiful relations Shown only by biochemistry
Replace a stupefied sense of wonder With something more wonderful Because natural
and understandable. Nature is more wonderful
When it is at least partly understood. Such
an understanding dawns
On the lay reader when he becomes
Acquainted with the biochemistry of the glands
In their relation to diseases such as goitre
And their effects on growth, sex, and reproduction. He will
begin to comprehend a little
The subtlety and beauty of the action
Of enzymes, viruses, and bacteriophages, These
substances which are on the borderland Between the
living and the non-living.
He will understand why the biochemist
Can speculate on the possibility
Of the synthesis of life without feeling
That thereby he is shallow or blasphemous. He will
understand that, on the contrary, He finds all the
more
Because he seeks for the endless
—’Even our deepest emotions
May be conditioned by traces
Of a derivative of phenanthrene!’
Science is the Differential
Calculus of the mind,
Art is the Integral Calculus;
they may be Beautiful apart, but are
great only when combined.
Sir Ronald Ross
Garrett & Grisham FM-6
,In this poem, MacDiarmid argues strongly for the importance of studying biochemistry to
understand and appreciate Nature itself. The poem was published in 1943, well before the
molecular revolution in biochemistry, well before the first protein structure was solved or
the first gene cloned yet MacDiarmid seems to have appreciated the importance of
enzyme kinetics and enzyme catalysis and to anticipate the value of recombinant DNA
technology: “The subtlety and beauty of the action of enzymes, viruses, and
bacteriophages.…” He even suggests that a fundamental understanding of life itself might
be possible through biochemistry.
It is interesting to see how biochemists are portrayed in movies and films in this
electronic age. In the 1996 film The Rock staring Sean Connery and Nicholas Cage, Cage
plays a biochemist enlisted by the FBI to deal with a threat involving VX gas warheads.
(VX is a potent acetylcholinesterase inhibitor.) Cage’s character, Stanley Goodspeed,
delivers this memorable line, which informs the audience of his expertise: “Look, I’m
just a biochemist. Most of the time, I work in a little glass jar and lead a very uneventful
life. I drive a Volvo, a beige one. But what I’m dealing with here is one of the most
deadly substances the earth has ever known, so what say you cut me some friggin’
slack!” Perhaps Stanley is overstating the danger inherent in his work but he is surely
understating the importance of his occupation.
Garrett & Grisham FM-7
,
