Virology Final Exam questions and
answers graded A+ updated
Prions are proteins that cause.... - correct answer ✔✔fatal brain diseases
Do prions contain nucleic acid? - correct answer ✔✔NO!
Prions transmit ____. - correct answer ✔✔prion disease
Describe Kuru. - correct answer ✔✔- Spread via cannibalism in the village
- South Fore Island, Papau New Guinea
- Caused neurological issues
Can chronic wasting disease (CWD) cross species yet? - correct answer ✔✔- Unsure
- Deer are sampled during hunting season for prions
What was the 1st discovered prion disease? - correct answer ✔✔Scrapie in sheep
Bovine spongiform encephalopathy (BSE), usually a cow/bovine disease, can be seen in humans
from a _______. This leads to basically Mad Cow Disease. - correct answer ✔✔genetic mutation
Prion proteins (PrPc) are encoded by... - correct answer ✔✔the host genome
, PrPc is found in _______ and binds _____. - correct answer ✔✔neuronal synapses; copper
Prion proteins became infectious and pathogenic (PrPSC) as a result of... - correct answer
✔✔protein conformational changes
PrPSC can catalyze its own formation from... - correct answer ✔✔PrPC in animals
PrPSC aggregates and accumulated in... - correct answer ✔✔the diseased brain
Describe the brain pathology in spongiform encephalopathy. - correct answer ✔✔large vacuoles
in cortex and cerebellum give brain a sponge-like look
Areas affected with prion diseases contain insoluble amyloid fibrils and ____. - correct answer
✔✔amyloid plaques
What are the human prion diseases? - correct answer ✔✔- Creutzfeldt-Jacob Disease (CJD)
- Kuru
Describe Scrapie. - correct answer ✔✔- Found in sheep and goats
- Marked by behavioral changes, tremor, and uncoordinated movements
- Will lead to death
answers graded A+ updated
Prions are proteins that cause.... - correct answer ✔✔fatal brain diseases
Do prions contain nucleic acid? - correct answer ✔✔NO!
Prions transmit ____. - correct answer ✔✔prion disease
Describe Kuru. - correct answer ✔✔- Spread via cannibalism in the village
- South Fore Island, Papau New Guinea
- Caused neurological issues
Can chronic wasting disease (CWD) cross species yet? - correct answer ✔✔- Unsure
- Deer are sampled during hunting season for prions
What was the 1st discovered prion disease? - correct answer ✔✔Scrapie in sheep
Bovine spongiform encephalopathy (BSE), usually a cow/bovine disease, can be seen in humans
from a _______. This leads to basically Mad Cow Disease. - correct answer ✔✔genetic mutation
Prion proteins (PrPc) are encoded by... - correct answer ✔✔the host genome
, PrPc is found in _______ and binds _____. - correct answer ✔✔neuronal synapses; copper
Prion proteins became infectious and pathogenic (PrPSC) as a result of... - correct answer
✔✔protein conformational changes
PrPSC can catalyze its own formation from... - correct answer ✔✔PrPC in animals
PrPSC aggregates and accumulated in... - correct answer ✔✔the diseased brain
Describe the brain pathology in spongiform encephalopathy. - correct answer ✔✔large vacuoles
in cortex and cerebellum give brain a sponge-like look
Areas affected with prion diseases contain insoluble amyloid fibrils and ____. - correct answer
✔✔amyloid plaques
What are the human prion diseases? - correct answer ✔✔- Creutzfeldt-Jacob Disease (CJD)
- Kuru
Describe Scrapie. - correct answer ✔✔- Found in sheep and goats
- Marked by behavioral changes, tremor, and uncoordinated movements
- Will lead to death
