NURS 430 EXAM 1 EXAM WITH
CORRECT QUESTIONS AND ANSWERS
2025
An 18-year-old female patient is brought to the emergency
department due to drug overdose. Which of the following routes
of administration is the most desirable for administering the
antidote for the drug overdose?
A. Intramuscular.
B. Subcutaneous.
C. Transdermal.
D. Oral.
E. Intravenous. - CORRECT-ANSWERS>>>>>>E. Intravenous.
The intravenous route of administration is the most desirable
because it results in achievement of therapeutic plasma levels of
the antidote rapidly.
KR2250 is an investigational cholesterol-lowering agent. KR2250
has a high molecular weight and is extensively bound to albumin.
,KR2250 will have a(n) _______________ apparent volume of
distribution (Vd).
A. High
B. Low
C. Extremely high
D. Normal - CORRECT-ANSWERS>>>>>>B. Low
Because of its high molecular weight and high protein binding,
KR2250 will be effectively trapped within the plasma (vascular)
compartment and will have a low apparent volume of distribution.
A 40-year-old male patient (70 kg) was recently diagnosed with
infection involving methicillin-resistant S. aureus. He received
2000 mg of vancomycin as an IV loading dose. The peak plasma
concentration of vancomycin was 28.5 mg/L. The apparent
volume of distribution is:
A. 1 L/kg
B. 7 L/kg
C. 10 L/kg
,D. 14 L/kg
E. 70 L/kg - CORRECT-ANSWERS>>>>>>A. 1 L/kg
Vd = dose/C = 2000 mg/28.5 mg/L = 70.1 L. Because the patient
is 70 kg, the apparent volume of distribution in L/kg will be
approximately 1 L/kg (70.1 L/70 kg).
A 55-year-old woman is brought to the emergency department
because of seizures. She has a history of renal disease and
currently undergoes dialysis. She receives an intravenous infusion
of antiseizure Drug X. Which of the following is likely to be
observed with use of Drug X in this patient in terms of the half life
and dosing as compared to a normal patient?
A. Half life increase, dosage increase
B. Half life decrease, dosage decrease
C. Half life increase, dosage same
D. Half life increase, dosage decrease
E. Half life same, dosage same - CORRECT-ANSWERS>>>>>>D.
Half life increase, dosage decrease
, Because the patient has a renal disorder, she may not be able to
excrete the drug effectively. Therefore, the half-life of Drug X will
be prolonged. As the half-life is prolonged, the dosage must be
reduced so the patient will not have serious toxic effects of Drug
X.
A 64-year-old female patient (60 kg) is treated with experimental
Drug A for type 2 diabetes. Drug A is available as tablets with an
oral bioavailability of 90%. If the Vd is 2 L/kg and the desired
steady-state plasma concentration is 3.0 mg/L, which of the
following is the most appropriate oral loading dose of Drug A?
A. 6 mg
B. 6.66 mg
C. 108 mg
D. 360 mg
E. 400 mg - CORRECT-ANSWERS>>>>>>E. 400 mg
For oral dosing, loading dose = [(Vd) × (desired steady-state
plasma concentration)/F]. The Vd in this case is corrected to the
patient's weight is 120 L. The F value is 0.9 (because
CORRECT QUESTIONS AND ANSWERS
2025
An 18-year-old female patient is brought to the emergency
department due to drug overdose. Which of the following routes
of administration is the most desirable for administering the
antidote for the drug overdose?
A. Intramuscular.
B. Subcutaneous.
C. Transdermal.
D. Oral.
E. Intravenous. - CORRECT-ANSWERS>>>>>>E. Intravenous.
The intravenous route of administration is the most desirable
because it results in achievement of therapeutic plasma levels of
the antidote rapidly.
KR2250 is an investigational cholesterol-lowering agent. KR2250
has a high molecular weight and is extensively bound to albumin.
,KR2250 will have a(n) _______________ apparent volume of
distribution (Vd).
A. High
B. Low
C. Extremely high
D. Normal - CORRECT-ANSWERS>>>>>>B. Low
Because of its high molecular weight and high protein binding,
KR2250 will be effectively trapped within the plasma (vascular)
compartment and will have a low apparent volume of distribution.
A 40-year-old male patient (70 kg) was recently diagnosed with
infection involving methicillin-resistant S. aureus. He received
2000 mg of vancomycin as an IV loading dose. The peak plasma
concentration of vancomycin was 28.5 mg/L. The apparent
volume of distribution is:
A. 1 L/kg
B. 7 L/kg
C. 10 L/kg
,D. 14 L/kg
E. 70 L/kg - CORRECT-ANSWERS>>>>>>A. 1 L/kg
Vd = dose/C = 2000 mg/28.5 mg/L = 70.1 L. Because the patient
is 70 kg, the apparent volume of distribution in L/kg will be
approximately 1 L/kg (70.1 L/70 kg).
A 55-year-old woman is brought to the emergency department
because of seizures. She has a history of renal disease and
currently undergoes dialysis. She receives an intravenous infusion
of antiseizure Drug X. Which of the following is likely to be
observed with use of Drug X in this patient in terms of the half life
and dosing as compared to a normal patient?
A. Half life increase, dosage increase
B. Half life decrease, dosage decrease
C. Half life increase, dosage same
D. Half life increase, dosage decrease
E. Half life same, dosage same - CORRECT-ANSWERS>>>>>>D.
Half life increase, dosage decrease
, Because the patient has a renal disorder, she may not be able to
excrete the drug effectively. Therefore, the half-life of Drug X will
be prolonged. As the half-life is prolonged, the dosage must be
reduced so the patient will not have serious toxic effects of Drug
X.
A 64-year-old female patient (60 kg) is treated with experimental
Drug A for type 2 diabetes. Drug A is available as tablets with an
oral bioavailability of 90%. If the Vd is 2 L/kg and the desired
steady-state plasma concentration is 3.0 mg/L, which of the
following is the most appropriate oral loading dose of Drug A?
A. 6 mg
B. 6.66 mg
C. 108 mg
D. 360 mg
E. 400 mg - CORRECT-ANSWERS>>>>>>E. 400 mg
For oral dosing, loading dose = [(Vd) × (desired steady-state
plasma concentration)/F]. The Vd in this case is corrected to the
patient's weight is 120 L. The F value is 0.9 (because
