Table of content
Graphical Abstract 2
Abstract 3
Stem Cell Therapy 3
1.1 Introduction 3
1.2 History of stem cell therapy 3
1.3 Importance of stem cell therapy 3
1.4 Types/Sources of stem cell therapy 4
1.4.1 Embryonic stem cells 4
1.4.2 Adult Stem cells 5
1.4.3 Induced Pluripotent stem cells 5
1.4.4 Fetal stem cells 6
1.4.5 Umbilical cord blood cells 6
1.4.6 Dental stem cells 6
1.4.7 Mesenchymal stem cells 6
1.4.8 Autogenous stem cells 7
1.4.9 Allogeneic Stem cells 7
1.5 Approaches of Stem cell therapy 7
1.5.1 In Vivo stem cell therapy 7
1.5.2 Ex Vivo stem cell therapy 8
1.6 Mechanism of action of stem cell therapy 8
1.6.1 Ability to differentiate 8
1.6.2 Release of Paracrine Signaling and growth factor 9
1.6.3 Immunodulation and anti – inflammatory effects 9
1.7 Application of stem cell therapy 10
1.8 Clinical Trials and Approvals 11
1.9 Risks/limitations/Ethical Issues 11
1.10 Future Perspective 12
Conclusion 12
References 13
1
, Graphical Abstract Clinical approvals and
Future Perspective Trials
Risks/Limitations/Ethical
Issues
Stem Cell Therapy
History
Importance
1958 – 1963 (discovery of stem cells & uses)
Embryonic stem cells
Induced Pluripotent stem cells Types and Dental stem cells
sources of Mesenchymal stem cells
Allogeneic stem cells stem cells
Application of stem cell
Autogenous stem cells Umbilical cord blood cells
therapy
Adult Stem cells Fetal Stem cells
Mechanism of action of Approaches of stem cell
stem cell therapy therapy
In Vivo Ex Vivo
Stem cells injected
Immune system rejection into the patient
and inflammation
Activate the endogenous cardiac
Growth cells which start angiogenesis
factors In vivo stem cell Ex vivo stem cell therap
therapy involves involves the use of
Angiogenesis the direct donor stem cells and
Cardiac
Repair Paracrine injection of stem differentiated outside
Metabolism, Signaling cells into the which is them injected
Cell survival patient into the body of patient
2
Graphical Abstract 2
Abstract 3
Stem Cell Therapy 3
1.1 Introduction 3
1.2 History of stem cell therapy 3
1.3 Importance of stem cell therapy 3
1.4 Types/Sources of stem cell therapy 4
1.4.1 Embryonic stem cells 4
1.4.2 Adult Stem cells 5
1.4.3 Induced Pluripotent stem cells 5
1.4.4 Fetal stem cells 6
1.4.5 Umbilical cord blood cells 6
1.4.6 Dental stem cells 6
1.4.7 Mesenchymal stem cells 6
1.4.8 Autogenous stem cells 7
1.4.9 Allogeneic Stem cells 7
1.5 Approaches of Stem cell therapy 7
1.5.1 In Vivo stem cell therapy 7
1.5.2 Ex Vivo stem cell therapy 8
1.6 Mechanism of action of stem cell therapy 8
1.6.1 Ability to differentiate 8
1.6.2 Release of Paracrine Signaling and growth factor 9
1.6.3 Immunodulation and anti – inflammatory effects 9
1.7 Application of stem cell therapy 10
1.8 Clinical Trials and Approvals 11
1.9 Risks/limitations/Ethical Issues 11
1.10 Future Perspective 12
Conclusion 12
References 13
1
, Graphical Abstract Clinical approvals and
Future Perspective Trials
Risks/Limitations/Ethical
Issues
Stem Cell Therapy
History
Importance
1958 – 1963 (discovery of stem cells & uses)
Embryonic stem cells
Induced Pluripotent stem cells Types and Dental stem cells
sources of Mesenchymal stem cells
Allogeneic stem cells stem cells
Application of stem cell
Autogenous stem cells Umbilical cord blood cells
therapy
Adult Stem cells Fetal Stem cells
Mechanism of action of Approaches of stem cell
stem cell therapy therapy
In Vivo Ex Vivo
Stem cells injected
Immune system rejection into the patient
and inflammation
Activate the endogenous cardiac
Growth cells which start angiogenesis
factors In vivo stem cell Ex vivo stem cell therap
therapy involves involves the use of
Angiogenesis the direct donor stem cells and
Cardiac
Repair Paracrine injection of stem differentiated outside
Metabolism, Signaling cells into the which is them injected
Cell survival patient into the body of patient
2
