TABLETS
CONTENTS
• INTRODUCTION
• IDEAL CHARACTERISTICKS OF TABLETS
• ADVANTAGE AND DISADVANTAG OF TABLETS
• CLASSIFICATION
INTRODUCTION
Tablets are solid dosage forms containing one or more drugs with or without the addition of excipients.
EXCIPIENTS: Are mainly incorporated to enhance physical appearance, stability, disintegration or
breakup of tablets after administration.
According to Indian pharmacopeia,
Pharmaceutical tablets are flat or bi-convex discs manufactured by compressing a drug or a mixture of
drug with or without suitable excipients.
IDEAL CHARACTERISTICS OF TABLETS
The main objective of the design and manufacture of compressed tablet is to deliver orally the correct
amount of drug in the proper form, at or over the proper time and in the desired location and to have
its chemical integrity protected.
➢ Should be elegant, free from defects.
➢ Should have strength to withstand the harshness of mechanical shock that can be encountered
in its production, packing shipping etc.
➢ Must be able to release the medicinal agent in the body in a predictable and reproducible
manner.
➢ Must be uniform in weight and drug content.
➢ Size and shape of the tablets influence the passing of product to GIT.
➢ Tablets should be physically and chemically stable so that no alternation of active ingredient
with time.
ADVANTAGES OF TABLETS
➢ Cheapest oral dosage form
➢ Easy to handle
➢ Convenient to administer and offer greatest dose precision
➢ Have the best combined properties of chemical, mechanical, and microbiological stability of
all the oral forms.
➢ Greatest ease of swallowing, and less shelf storage space.
➢ Suitable for large scale production
, Unpleasant and bitter tasting drugs when formulating, the taste can be masked with excipients
suitable.
➢ Provide protection of medicaments from atmospheric condition.
DISADVANTEGES OF TABLETS
➢ Some of drugs, due to their highly atmospheric nature and low density, are difficult to
compress.
➢ Chances of loss of ingredients of tablets during manufacturing because of involvement of
several unit of operations.
➢ Drug with poor wetting properties and slow dissolution rate are difficult to be dispensed in
the form of tablets.
➢ Drug with objectionable odor and bitter tasting substance needs special treatments for
compression. This can increase the cost of production.
➢ Bio availability problem may arise due to slow disintegration and slow dissolution.
➢ Some drugs can cause irritant effect on GIT.
CLASSIFICATION OF TABLETS
04 MAJOR TYPES
ORALLY INGESTED TABLETS
TABLETS FOR ORAL CAVITY
TABLET TO PREPARE SOLUTION
TABLETS GIVEN THRUGH OTHER ROUTES
ORALLY INGESTED TABLETS
Majority of the tablets are ingested orally. This tablets are swallowed intact along with sufficient
quantity of water.
I. COMPRESSED TABLETS: Prepared by compression of powdered crystalline or granular
materials, by the application of high pressure using punches and die. They are not containing
any special coating. Here rapid disintegration occurs which releases the drug rapidly.
II. Multi- compressed tablets: composed of 2-3 layers. Prepared by indroducing the fill material
to more than one compression cycle. Multi compression is done incase where the
ingredients are physically or chemically incompatible or when a prolonged action is required.
They are further classified into 03.
a. Compression coated tablets
b. Layered tablets
c. Inlay tablets
CONTENTS
• INTRODUCTION
• IDEAL CHARACTERISTICKS OF TABLETS
• ADVANTAGE AND DISADVANTAG OF TABLETS
• CLASSIFICATION
INTRODUCTION
Tablets are solid dosage forms containing one or more drugs with or without the addition of excipients.
EXCIPIENTS: Are mainly incorporated to enhance physical appearance, stability, disintegration or
breakup of tablets after administration.
According to Indian pharmacopeia,
Pharmaceutical tablets are flat or bi-convex discs manufactured by compressing a drug or a mixture of
drug with or without suitable excipients.
IDEAL CHARACTERISTICS OF TABLETS
The main objective of the design and manufacture of compressed tablet is to deliver orally the correct
amount of drug in the proper form, at or over the proper time and in the desired location and to have
its chemical integrity protected.
➢ Should be elegant, free from defects.
➢ Should have strength to withstand the harshness of mechanical shock that can be encountered
in its production, packing shipping etc.
➢ Must be able to release the medicinal agent in the body in a predictable and reproducible
manner.
➢ Must be uniform in weight and drug content.
➢ Size and shape of the tablets influence the passing of product to GIT.
➢ Tablets should be physically and chemically stable so that no alternation of active ingredient
with time.
ADVANTAGES OF TABLETS
➢ Cheapest oral dosage form
➢ Easy to handle
➢ Convenient to administer and offer greatest dose precision
➢ Have the best combined properties of chemical, mechanical, and microbiological stability of
all the oral forms.
➢ Greatest ease of swallowing, and less shelf storage space.
➢ Suitable for large scale production
, Unpleasant and bitter tasting drugs when formulating, the taste can be masked with excipients
suitable.
➢ Provide protection of medicaments from atmospheric condition.
DISADVANTEGES OF TABLETS
➢ Some of drugs, due to their highly atmospheric nature and low density, are difficult to
compress.
➢ Chances of loss of ingredients of tablets during manufacturing because of involvement of
several unit of operations.
➢ Drug with poor wetting properties and slow dissolution rate are difficult to be dispensed in
the form of tablets.
➢ Drug with objectionable odor and bitter tasting substance needs special treatments for
compression. This can increase the cost of production.
➢ Bio availability problem may arise due to slow disintegration and slow dissolution.
➢ Some drugs can cause irritant effect on GIT.
CLASSIFICATION OF TABLETS
04 MAJOR TYPES
ORALLY INGESTED TABLETS
TABLETS FOR ORAL CAVITY
TABLET TO PREPARE SOLUTION
TABLETS GIVEN THRUGH OTHER ROUTES
ORALLY INGESTED TABLETS
Majority of the tablets are ingested orally. This tablets are swallowed intact along with sufficient
quantity of water.
I. COMPRESSED TABLETS: Prepared by compression of powdered crystalline or granular
materials, by the application of high pressure using punches and die. They are not containing
any special coating. Here rapid disintegration occurs which releases the drug rapidly.
II. Multi- compressed tablets: composed of 2-3 layers. Prepared by indroducing the fill material
to more than one compression cycle. Multi compression is done incase where the
ingredients are physically or chemically incompatible or when a prolonged action is required.
They are further classified into 03.
a. Compression coated tablets
b. Layered tablets
c. Inlay tablets
