answers
1. STEP-BD Study: systematic treatment enhancement for bipolar disorder. A
study that
2. Lithium, SGAs, Valproate: Monotherapy with which first-line drugs should
be prescribed for less severe acute manic episodes?
3. 4-5: About 1 in ___ untreated or inadequately treated bipolar patients
commits suicide.
4. Antidepressants: Mood stabilizers appear to share neurobiological actions
with
5. True: True or false
Topiramate was no more effective than placebo when combined with either
valproate or lithium for the treatment of bipolar I disorder
6. A, B, C, D: Where have controlled trials demonstrated lithium's efficacy?
A. Type 1 and type II bipolar disorders
B. Acute Mania
C. Acute depressive episodes
D. Maintenance treatment for relapse prevention
7. Manic Switch: The administration of antidepressants can result in a _____
______
8. 4: A patient is labeled a rapid cycler if at least ___ illness episodes occur
within a 12-month period.
9. alcohol: Which of the following drugs do bipolar patients most frequently
abuse?
10. There is not sufficient evidence: How useful are omega-3 fatty acids in
treating bipolar disorder?
11. D: What is the risk of recurrence of bipolar episodes over 4 years?
, A. 24%
B. 36%
C. 45%
D. 61%
12. C: What did the STEP-BD study reveal about treatment of bipolar
depression?
A. combining a mood stabilizer with a standard antidepressant produced greater
benefit and less risk of a manic switch than mood-stabilizing monotherapy alone
B. lithium monotherapy produced greater benefit and less risk of a manic switch
than anticonvulsant monotherapy
C. mood-stabilizing monotherapy provided as much benefit and risk of a manic
switch as combining a mood stabilizer with a standard antidepressant
D. patients who failed to respond to a combination of a mood stabilizer and at
least one antidepressant showed a strong therapeutic response when risperidone
was added
13. D: Which statement about valproic acid (Depakene) is correct?
A. Valproic acid is more effective than lithium for rapid-cycling bipolar disorder with
comorbid substance abuse
B. Unlike lithium, valproic is not teratogenic
C. Valproic acid is more effective than lithium for rapid-cycling bipolar disorder
D. The combination of valproic acid and lithium may be more efficacious than
either agent alone
14. carbamazepine (Tegretol): Oxcarbazepine (Trileptal) is a safer and equally
efficacious replacement for
15. C: Which statement about combination therapy is correct?