GMS 6504 MODULE 1-3 Exam 1
correctly answered already passed
Affinity
Efficacy - correct answer ✔✔What are System Independent Parameters?
Number of receptors
Cellular machinery
Presence of other drugs
- Competitive
- Noncompetitive - correct answer ✔✔What are the parts of a system that are identified as
System Dependent Parameters?
Thermokinetic propensity of drug to bind to receptor
Based largely on ΔG - correct answer ✔✔Affinity is
Magnitude of change of receptor shape/function upon drug binding
Based on atom/atom interactions - correct answer ✔✔Efficacy is
Response is proportional to fraction of receptors that are occupied
100% response is obtained when all receptors have ligand - correct answer ✔✔What is the
Occupancy Theory?
, Langmuir equation
DR/Rt = r = D/D+Kd - correct answer ✔✔What formula do we use to predict occupancy?
A+R --> (AR) - correct answer ✔✔How do we define response effect?
Alpha
Multiplication factor describing ability of agonist to produce a stimulus - correct answer
✔✔Intrinsic activity is depicted as what letter?
How is it defined?
α = 1 - correct answer ✔✔In terms of intrinsic activity, what is determined to be a full agonist?
0 < α < 1 - correct answer ✔✔In terms of intrinsic activity, what is determined to me a partial
agonist?
α = 0 - correct answer ✔✔In terms of intrinsic activity, what is determined to be an antagonist?
R = f ( α x r x Rt )
f = stimulus response
Rt = receptor number - correct answer ✔✔What is the formula for the estimation of relative
efficacy?
Binding of a ligand to a receptor causes a conformational change
correctly answered already passed
Affinity
Efficacy - correct answer ✔✔What are System Independent Parameters?
Number of receptors
Cellular machinery
Presence of other drugs
- Competitive
- Noncompetitive - correct answer ✔✔What are the parts of a system that are identified as
System Dependent Parameters?
Thermokinetic propensity of drug to bind to receptor
Based largely on ΔG - correct answer ✔✔Affinity is
Magnitude of change of receptor shape/function upon drug binding
Based on atom/atom interactions - correct answer ✔✔Efficacy is
Response is proportional to fraction of receptors that are occupied
100% response is obtained when all receptors have ligand - correct answer ✔✔What is the
Occupancy Theory?
, Langmuir equation
DR/Rt = r = D/D+Kd - correct answer ✔✔What formula do we use to predict occupancy?
A+R --> (AR) - correct answer ✔✔How do we define response effect?
Alpha
Multiplication factor describing ability of agonist to produce a stimulus - correct answer
✔✔Intrinsic activity is depicted as what letter?
How is it defined?
α = 1 - correct answer ✔✔In terms of intrinsic activity, what is determined to be a full agonist?
0 < α < 1 - correct answer ✔✔In terms of intrinsic activity, what is determined to me a partial
agonist?
α = 0 - correct answer ✔✔In terms of intrinsic activity, what is determined to be an antagonist?
R = f ( α x r x Rt )
f = stimulus response
Rt = receptor number - correct answer ✔✔What is the formula for the estimation of relative
efficacy?
Binding of a ligand to a receptor causes a conformational change
