USMLE Step 1 First Aid Rapid Review / FULL
Comprehensive Practice Q-Bank / Newest Actual
Questions & Answers (A+ Guide Solution)
Budd-Chiari Syndrome (post hepatic venous thrombosis). Associated with
Polycythemia vera. - (ANSWER)Abdominal pain, ascites, hepatomegaly
Familial Hypercholesterolemia (absent/defective LDL receptors)
May have MI before age 20
Autosomal dominant - (ANSWER)Achilles tendon Xanthoma
Waterhouse-Friedrichsen syndrome (Neisseria meningitidis) - (ANSWER)Adrenal
hemorrhage, hypotension, DIC
IgA deficiency; C1 inhibitor deficiency would only cause angioedema, not
anaphylaxis - (ANSWER)Anaphylaxis and/or angioedema following blood
transfusion
Marfan Syndrome (FBN1 gene mutation
chromosome 15 leads to defective fibrillin)
Autosomal Dominant - (ANSWER)Arachnodactyly (spider fingers), lens
dislocation, aortic dissection or aneurysm, hyperflexible joints, pectus excavatum
Secondary to EPO injection - (ANSWER)Athlete with polycythemia
,Pott disease (vertebral TB) - (ANSWER)Back pain, fever, night sweats
Neurofibromatosis type 2
S-100+, cerebellopontine angle - (ANSWER)Bilateral acoustic schwannomas
Sarcoidosis (non-caseating granulomas) - (ANSWER)Bilateral hilar adenopathy,
uveitis, high ACE, hypercalcemia (activated macrophages for Vit D), interstitial
fibrosis, erythema nodosum, elevated CD4:CD8 ratio on lavage; asteroid bodies
Mucor or Rhizopus fungal infection
Travels through cribiform plate vessels - (ANSWER)Black eschar on face of patient
with diabetic ketoacidosis
Osteogenesis Imperfecta (Type I collagen defect forming triple helix)
Blue due to exposure of choroidal veins - (ANSWER)Blue sclera
Burton line (lead poisoning)
Basophilic stippling (rRNA remnants)
Constipation, anemia, CNS impairment - (ANSWER)Bluish line on gingiva and
basophilic stippling
Paget disease of bone (Increased osteoclastic, then osteoblastic activity)
,Osteosarcoma or heart failure - (ANSWER)Bone pain, bone enlargement (hat size
or hearing loss), arthritis
Aortic Regurgitation - (ANSWER)Bounding pulses, wide pulse pressure, diastolic
heart murmur, head bobbing
Systemic lupus erythematosus
Type III Hypersensitivity (antigen-antibody complexes deposit) with
glomerulonephritis
Type II hypersensitivity with autoimmune hemolysis - (ANSWER)"Butterfly" facial
rash or discoid rash and Raynaud phenomenon in a young female
Lymphatics to lymph nodes (except HCC, Renal cell, follicular thyroid and
choriocarcinoma which spread hematogenously) - (ANSWER)Carcinoma spread
Hematogenously - (ANSWER)Sarcoma spread
Neurofibromatosis Type I, pheochromocytoma, optic gliomas - (ANSWER)Cafe-
au-lait spots, Lisch nodules (iris hemartoma), cutaneous neurofibromas
McCune-Albright syndrome (mosaicism, G-protein signaling mutation) -
(ANSWER)Cafe-au-lait spots (unilateral), polyostotic fibrous dysplasia, precocious
puberty, multiple endocrine abnormalities
, Muscular dystrophy (Duchenne, due to X-linked frameshift > truncated
dystrophin)
Dilated cardiomyopathy
High CK - (ANSWER)Calf pseudohypertrophy
Kawasaki disease (treat with IVIG and aspirin which inhibits TXA2) -
(ANSWER)Cervical lymphadenopathy, desquamating rash on palms and soles,
coronary aneurysms, red conjuctivae, and strawberry tongue
Tay-Sachs (ganglioside accumulation - NO hepatosplenomegaly)
Niemann-Pick (sphingomyelin accumulation)
Central retinal artery occlusion - (ANSWER)"Cherry-red spots" on macula
Angina (stable: with moderate exertion, *cellular swelling indicates reversibility*,
atherosclerosis; unstable: with minimal exertion or at rest, partial occlusion) -
(ANSWER)Chest pain on exertion
Dressler syndrome (autoimmune reaction to necrotic tissue causing fibrinous
pericarditis, 2-12 weeks after acute episode) - (ANSWER)Chest pain, pericardial
effusion/friction rub, persistent fever weeks after an MI
Subendocaridal ischemia
Unstable angina (troponins -, reversible) and NSTEMI (troponins +, irreversible) -
(ANSWER)Chest pain with ST depressions EKG
Comprehensive Practice Q-Bank / Newest Actual
Questions & Answers (A+ Guide Solution)
Budd-Chiari Syndrome (post hepatic venous thrombosis). Associated with
Polycythemia vera. - (ANSWER)Abdominal pain, ascites, hepatomegaly
Familial Hypercholesterolemia (absent/defective LDL receptors)
May have MI before age 20
Autosomal dominant - (ANSWER)Achilles tendon Xanthoma
Waterhouse-Friedrichsen syndrome (Neisseria meningitidis) - (ANSWER)Adrenal
hemorrhage, hypotension, DIC
IgA deficiency; C1 inhibitor deficiency would only cause angioedema, not
anaphylaxis - (ANSWER)Anaphylaxis and/or angioedema following blood
transfusion
Marfan Syndrome (FBN1 gene mutation
chromosome 15 leads to defective fibrillin)
Autosomal Dominant - (ANSWER)Arachnodactyly (spider fingers), lens
dislocation, aortic dissection or aneurysm, hyperflexible joints, pectus excavatum
Secondary to EPO injection - (ANSWER)Athlete with polycythemia
,Pott disease (vertebral TB) - (ANSWER)Back pain, fever, night sweats
Neurofibromatosis type 2
S-100+, cerebellopontine angle - (ANSWER)Bilateral acoustic schwannomas
Sarcoidosis (non-caseating granulomas) - (ANSWER)Bilateral hilar adenopathy,
uveitis, high ACE, hypercalcemia (activated macrophages for Vit D), interstitial
fibrosis, erythema nodosum, elevated CD4:CD8 ratio on lavage; asteroid bodies
Mucor or Rhizopus fungal infection
Travels through cribiform plate vessels - (ANSWER)Black eschar on face of patient
with diabetic ketoacidosis
Osteogenesis Imperfecta (Type I collagen defect forming triple helix)
Blue due to exposure of choroidal veins - (ANSWER)Blue sclera
Burton line (lead poisoning)
Basophilic stippling (rRNA remnants)
Constipation, anemia, CNS impairment - (ANSWER)Bluish line on gingiva and
basophilic stippling
Paget disease of bone (Increased osteoclastic, then osteoblastic activity)
,Osteosarcoma or heart failure - (ANSWER)Bone pain, bone enlargement (hat size
or hearing loss), arthritis
Aortic Regurgitation - (ANSWER)Bounding pulses, wide pulse pressure, diastolic
heart murmur, head bobbing
Systemic lupus erythematosus
Type III Hypersensitivity (antigen-antibody complexes deposit) with
glomerulonephritis
Type II hypersensitivity with autoimmune hemolysis - (ANSWER)"Butterfly" facial
rash or discoid rash and Raynaud phenomenon in a young female
Lymphatics to lymph nodes (except HCC, Renal cell, follicular thyroid and
choriocarcinoma which spread hematogenously) - (ANSWER)Carcinoma spread
Hematogenously - (ANSWER)Sarcoma spread
Neurofibromatosis Type I, pheochromocytoma, optic gliomas - (ANSWER)Cafe-
au-lait spots, Lisch nodules (iris hemartoma), cutaneous neurofibromas
McCune-Albright syndrome (mosaicism, G-protein signaling mutation) -
(ANSWER)Cafe-au-lait spots (unilateral), polyostotic fibrous dysplasia, precocious
puberty, multiple endocrine abnormalities
, Muscular dystrophy (Duchenne, due to X-linked frameshift > truncated
dystrophin)
Dilated cardiomyopathy
High CK - (ANSWER)Calf pseudohypertrophy
Kawasaki disease (treat with IVIG and aspirin which inhibits TXA2) -
(ANSWER)Cervical lymphadenopathy, desquamating rash on palms and soles,
coronary aneurysms, red conjuctivae, and strawberry tongue
Tay-Sachs (ganglioside accumulation - NO hepatosplenomegaly)
Niemann-Pick (sphingomyelin accumulation)
Central retinal artery occlusion - (ANSWER)"Cherry-red spots" on macula
Angina (stable: with moderate exertion, *cellular swelling indicates reversibility*,
atherosclerosis; unstable: with minimal exertion or at rest, partial occlusion) -
(ANSWER)Chest pain on exertion
Dressler syndrome (autoimmune reaction to necrotic tissue causing fibrinous
pericarditis, 2-12 weeks after acute episode) - (ANSWER)Chest pain, pericardial
effusion/friction rub, persistent fever weeks after an MI
Subendocaridal ischemia
Unstable angina (troponins -, reversible) and NSTEMI (troponins +, irreversible) -
(ANSWER)Chest pain with ST depressions EKG
