N115 TAKE HOME MIDTERM UPDATED
ACTUAL Exam Questions and CORRECT
Answers
Which one of the following is not a major feature of an ideal drug?
a. demonstrated effectiveness
b. covalent interaction with receptor
c. receptor selectivity
d. no adverse effects - CORRECT ANSWER - ANS: B
Variability of drug response in an individual patient may be introduced by which of the
following:
1. genetic differences in drug metabolism
2. covalent interaction with receptor
3. poor compliance and missed doses
4. inadequate record keeping
a. 1 and 2
b. 1 and 3
c. 1,3,4
d. all of the above - CORRECT ANSWER - ANS: B
Large multi-site clinical trials, usually with thousands of subjects, are conducted in which phase
of drug evaluation prior to FDA approval?
a. Preclinical drug screening
,b. Phase 1
c. Phase 2
d. Phase 3 - CORRECT ANSWER - ANS: D
Which one of the following is the ultimate factor that determines the intensity of drug response?
1. cellular location of the receptor [intra vs. extracellular]
2. drug concentration at receptor site
3. proportion of nonionized activity to ionized activity
4. prescribed dose
a. 1 only
b. 2 only
c. 1,2,4
d. all of the above - CORRECT ANSWER - ANS: B
Which of the following pharmacokinetics term describes how drugs move from the site of
administration to the circulation?
a. Absorption
b. Distribution
c. Metabolism
d. Excretion - CORRECT ANSWER - ANS: A
Which of the following is true regarding a drug that binds extensively to plasma proteins?
a. will likely have a large volume of distribution [Vd]
b. will be readily eliminated by the kidney
, c. is unlikely to affect the bioavailability of other drugs
d. only unbound drug is available for distribution - CORRECT ANSWER - ANS: D
Acidification of the urine by high doses of Vitamin C [ascorbic acid] may result in:
a. better elimination of meperidine [Demerol], a basic drug, due to ion trapping
b. better elimination of aspirin, an acidic drug, due to ion trapping
c. altered concentration gradient and faster absorption of meperidine [Demerol], a basic drug
d. altered concentration gradient and faster absorption of aspirin, an acidic drug - CORRECT
ANSWER - ANS: A
Which of the following does NOT influence the degree to which a drug moves by passive
diffusion?
a. the concentration gradient between the two compartments
b. the lipophilicity of a drug
c. the proportion of drug that is charged
d. the degree of gastric absorption - CORRECT ANSWER - ANS: D
A depot injection preparation can be given by which of the following routes?
a. IV
b. IM
c. subcutaneous
d. b and c - CORRECT ANSWER - ANS: D
Based on the degree of distribution, which one of the following drugs will reach the highest
concentration in the plasma?
ACTUAL Exam Questions and CORRECT
Answers
Which one of the following is not a major feature of an ideal drug?
a. demonstrated effectiveness
b. covalent interaction with receptor
c. receptor selectivity
d. no adverse effects - CORRECT ANSWER - ANS: B
Variability of drug response in an individual patient may be introduced by which of the
following:
1. genetic differences in drug metabolism
2. covalent interaction with receptor
3. poor compliance and missed doses
4. inadequate record keeping
a. 1 and 2
b. 1 and 3
c. 1,3,4
d. all of the above - CORRECT ANSWER - ANS: B
Large multi-site clinical trials, usually with thousands of subjects, are conducted in which phase
of drug evaluation prior to FDA approval?
a. Preclinical drug screening
,b. Phase 1
c. Phase 2
d. Phase 3 - CORRECT ANSWER - ANS: D
Which one of the following is the ultimate factor that determines the intensity of drug response?
1. cellular location of the receptor [intra vs. extracellular]
2. drug concentration at receptor site
3. proportion of nonionized activity to ionized activity
4. prescribed dose
a. 1 only
b. 2 only
c. 1,2,4
d. all of the above - CORRECT ANSWER - ANS: B
Which of the following pharmacokinetics term describes how drugs move from the site of
administration to the circulation?
a. Absorption
b. Distribution
c. Metabolism
d. Excretion - CORRECT ANSWER - ANS: A
Which of the following is true regarding a drug that binds extensively to plasma proteins?
a. will likely have a large volume of distribution [Vd]
b. will be readily eliminated by the kidney
, c. is unlikely to affect the bioavailability of other drugs
d. only unbound drug is available for distribution - CORRECT ANSWER - ANS: D
Acidification of the urine by high doses of Vitamin C [ascorbic acid] may result in:
a. better elimination of meperidine [Demerol], a basic drug, due to ion trapping
b. better elimination of aspirin, an acidic drug, due to ion trapping
c. altered concentration gradient and faster absorption of meperidine [Demerol], a basic drug
d. altered concentration gradient and faster absorption of aspirin, an acidic drug - CORRECT
ANSWER - ANS: A
Which of the following does NOT influence the degree to which a drug moves by passive
diffusion?
a. the concentration gradient between the two compartments
b. the lipophilicity of a drug
c. the proportion of drug that is charged
d. the degree of gastric absorption - CORRECT ANSWER - ANS: D
A depot injection preparation can be given by which of the following routes?
a. IV
b. IM
c. subcutaneous
d. b and c - CORRECT ANSWER - ANS: D
Based on the degree of distribution, which one of the following drugs will reach the highest
concentration in the plasma?
