Exam 1, Version B
First, enter your name and student ID on the answer sheet. Write your version number on the answer sheet in the margin. Choose the
best answer to each question, using a number 2 pencil. Be sure to ask if you aren’t sure about the intent of any question.
1. Which molecule can diffuse through the lipid bilayer?
A. H2O
B. K+
C. Glucose
D. Estrogen
2. Choose the TRUE statement:
A. An agonist will bind to a receptor and activate it.
B. Most hormones only bind to one type of receptor.
C. Most receptors bind and respond to multiple hormones.
D. Most cells have receptors for most hormones.
3. Release of epinephrine from sympathetic neurons increases heart rate. Drug X blocks this effect. Which of the following could
NOT be a mechanism by which Drug X works.
A. Drug X could be an antagonist to epinephrine, binding to the receptor for epinephrine on heart cells
B. Drug X could inhibit adenyl cyclase in the heart.
C. Drug X could inhibit the enzyme that degrades epinephrine after it binds to its receptor.
D. Drug X could block epinephrine synthesis in sympathetic neurons.
4. Choose the FALSE statement:
A. Proteins can be made from fat.
B. Fat can be made from protein.
C. Lipid (fat) contains more energy per gram than sugar.
D. When amino acids are catabolized, an amine (NH2) group is removed that is usually excreted.
5. A 1 M NaCl solution and a 1 M glucose solution are separated by a membrane that is permeable to water but not to glucose or
NaCl. Choose the true statement:
A. Water will move from the NaCl solution into the glucose solution.
B. The NaCl solution is isosmotic with the glucose solution.
C. The volume will increase on the NaCl side of the membrane.
D. The glucose solution is hyperosmotic relative to the NaCl solution.
6. Compared to water-soluble hormones, lipid-soluble hormones are generally:
A faster acting
B. shorter-lasting
C. more likely to bind to membrane-bound receptors
D. more likely to be bound to plasma proteins
7. Calcium or phosphate binding to proteins can change protein shape and activity. Based on your knowledge of how calcium and
phosphate affect proteins, choose the molecule that is mostly likely to change protein shape and activity by binding to it.
A. Water
B. Mg++
C. Glucose
D. N2
8. Calculate the diffusion rate for compound X across the membrane (outside to inside). Assume that all units cancel (no unit
conversions are required). Permeability constant (k p) = 3, area = 2, concentration outside = 5, concentration inside = 1.
A. 24
B. 30
C. 6
D. 8/3
E. 10/3
V er sion B
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, 9. Choose the FALSE statement:
A. Glycolytic enzymes occur in the cytoplasm.
B. During aerobic conditions, pyruvate produced by glycolysis eventually is oxidized by the mitochondria.
C. When no oxygen is present, lactate is produced in humans, regenerating NAD and allowing continued generation of ATP by
glycolysis.
D. When no oxygen is present, all ATP production stops.
10. Which hormone is NOT secreted by the anterior pituitary?
A.growth hormone
B. thyroid stimulating hormone
C. prolactin
D. cortisol
11. Choose the TRUE statement:
A. Circadian rhythm cycles arise in special cells in the liver.
B. Down-regulation of receptors results in an increased response to the signal.
C. In negative feedback systems, the effector moves the system in the opposite direction as the stimulus.
D. Glucagon secretion in response to declining blood glucose is an example of feed-forward regulation.
12. Choose the TRUE statement about glycolysis:
A. NADH is a required input
B. Pyruvate is an output
C. Oxygen is a required input
D. A and B are correct
E. A, B and C are correct
13. Choose the TRUE statement:
A. A drug that uncouples mitochondria will cause oxygen consumption and heat production by the mitochondria to increase.
B. A drug that blocks the electron transport chain in the mitochondria will increase activity of the Na+/K+ ATPases in cell membranes.
C. A drug that blocks the electron transport chain in the mitochondria will cause ATP production to increase.
D. A drug that blocks the electron transport chain in the mitochondria will cause CO2 output by the cell to increase.
14. A cell is placed into solution containing glucose. Over time, the glucose concentration in the cell rises to a stable level that is
equal to the concentration outside of the cell. This pattern indicates:
A. Saturation of the glucose transporters
B. facilitated diffusion of glucose
C. active transport of glucose
D. competition at the glucose transporters
15. Giving men exogenous synthetic testosterone (anabolic steroids) would be expected to:
A. decrease their secretion of LH (luetinizing hormone)
B. decrease their secretion of GnRH (gonadotropin releasing hormone)
C. decrease their endogenous secretion of natural testosterone.
D. A and B are correct
E. A, B and C are correct
16. Choose the example that best illustrates negative feedback regulation.
A. Bears put on fat in the fall to prepare for hibernation.
B. When the sun is bright, the pupil of the eye constricts, so the amount of light hitting the pupil remains at the proper level.
C. Mildred accelerates as she approaches the finish line.
D. During part of the menstrual cycle, a rise in estrogen levels causes an increase in FSH and LH secretion by the pituitary, which
cause a further rise in estrogen secretion by the ovary.
17. Dexamethasone is a drug that is used to suppress secretion of adenocorticotrophic hormone (ACTH) from the anterior pituitary.
Two patients with high levels of cortisol are given dexamethasone. Patient A’s cortisol secretion remains elevated, while Patient B’s
cortisol secretion falls to normal. The conclusion best supported by these data are that:
A. Patient B’s hypothalamus is malfunctioning.
B. Patient B’s anterior pituitary was secreting too much ACTH
C. Patient A’s adrenal cortex is functioning normally.
D. Patient A’s hypothalamus is malfunctioning.
V er sion B
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