PHC6001: Final Exam questions and answers
already passed
1. Since center trials Take place at one research site
2. Multicenter trials Take place at more than one research site
Collaborative, more participants
3. Sample size You need enough participants to have a high enough
statistical power
4. Treating Assignment Should be random (flipping a coin)
**this is done to avoid bias
Goal of randomization is to achieve baseline comparability
between compared groups on factors related to outcome
The larger the groups, the better randomization
works Blocking: randomization in small
groups
5. Stratification Separate participants by characteristics that you want to be
similar
in both groups
6. Placebo "sugar pill"
7. Masking of subjects Participants don't know what arm they're in
8. Masking of investigators Investigator doesn't know which arm a participant is in
9. Single masked The study participants only are masked
11 Triple
. mask 1/
11
,PHC6001: Final Exam questions and answers
already passed
10. Double mask The study participants and investigators who administer
treatment
are masked
11 Triple
. mask 1/
11
, PHC6001: Final Exam
Study online at
https://quizlet.com/_e9b496
The study participants, investigators who administer treatment,
and investigators who evaluate the outcome are masked
12. Non-compliance Failure to adhere to the study protocol
Reasons include: bas reaction, lack of interest, inconvenience,
etc
13. Run in or Lead in Some studies will conduct a mini study of compliance with
potential
participants
Put them on the treatment or control and see how well the
regimen is tolerated
Only compliant participants actually get enrolled
14. Target vs study population Study population is the subset of the target population
15. Loss to follow up A participant not active in the follow up of the trial
16. Parallel trials Have one treatment per treatment "arm" or
group One group assigned new therapy,
one old therapy One assignment
throughout the trial
17. Crossover trials Give the treatments to both arms in ditterent orders
One group starts with new treatment, switches
to old One group starts with old treatment
switches to new No control; participants are
their own controls
18. Simple vs factorial Simple: each group gets one treatment
Factorial: multiple treatments given to ditterent groups
19 Randomized clinical
. trials 2/
11
already passed
1. Since center trials Take place at one research site
2. Multicenter trials Take place at more than one research site
Collaborative, more participants
3. Sample size You need enough participants to have a high enough
statistical power
4. Treating Assignment Should be random (flipping a coin)
**this is done to avoid bias
Goal of randomization is to achieve baseline comparability
between compared groups on factors related to outcome
The larger the groups, the better randomization
works Blocking: randomization in small
groups
5. Stratification Separate participants by characteristics that you want to be
similar
in both groups
6. Placebo "sugar pill"
7. Masking of subjects Participants don't know what arm they're in
8. Masking of investigators Investigator doesn't know which arm a participant is in
9. Single masked The study participants only are masked
11 Triple
. mask 1/
11
,PHC6001: Final Exam questions and answers
already passed
10. Double mask The study participants and investigators who administer
treatment
are masked
11 Triple
. mask 1/
11
, PHC6001: Final Exam
Study online at
https://quizlet.com/_e9b496
The study participants, investigators who administer treatment,
and investigators who evaluate the outcome are masked
12. Non-compliance Failure to adhere to the study protocol
Reasons include: bas reaction, lack of interest, inconvenience,
etc
13. Run in or Lead in Some studies will conduct a mini study of compliance with
potential
participants
Put them on the treatment or control and see how well the
regimen is tolerated
Only compliant participants actually get enrolled
14. Target vs study population Study population is the subset of the target population
15. Loss to follow up A participant not active in the follow up of the trial
16. Parallel trials Have one treatment per treatment "arm" or
group One group assigned new therapy,
one old therapy One assignment
throughout the trial
17. Crossover trials Give the treatments to both arms in ditterent orders
One group starts with new treatment, switches
to old One group starts with old treatment
switches to new No control; participants are
their own controls
18. Simple vs factorial Simple: each group gets one treatment
Factorial: multiple treatments given to ditterent groups
19 Randomized clinical
. trials 2/
11
