Rush - Advanced Pharmacology - NSG 531 - Exam /2026
ACTUAL COMPLETE REAL EXAM QUESTIONS WITH CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS) ALREADY
PASSED!! GRADED A+ /2025 BRAND NEW EXAM!!
what are the four things that the body does to a drug? -
ANSWER-1. absorbs it 2. distributes it (think about it - most
drugs don't have MOA in the stomach or GI tract, the body
distributes to where it acts)
3. biotransforms or metabolizes it
4. eliminates it
What orally administered loading dose would achieve a plasma
concentration of
25 micrograms/mL for a drug that has a VD of 30 Liters and 90%
bioavailability?
(1 mg = 1000 ug) - ANSWER-total amount of drug in the body
is 25 ug/mL x
30,000 mL = 750,000 ug =
750 mg
we need 750 mg to achieve desired plasma concentration. (25
ug/mL) given VD
(30L)
,Bioavailability is 90%, we need to give more drug than 750 mg
to achieve the desired plasma concentration, because we know
that 10% will never reach the plasma
So
750/90 =
x/100
x=833.3 mg
What rate of IV infusion is needed to maintain a drug plasma
level of 45 ug/mL in a 70 kg man if the systemic clearance of
the drug is 50 mL/min? – ANSWER-2250 ug/min
How many half lifes does it typically take before we hit
steady state
concentration? - ANSWER-usually 4-6
half lifes
What is most important to know when calculating loading
dose? – ANSWER-volume of distribution
we need to know the concentration that we are trying to reach
and the volume of distribution (how big is the bucket we are
going to put the drug into) if the bucket is big we need a bigger
loading dose
,how do you calculate the amount of drug in the body - ANSWER-
essentially it is
the volume of distribution x plasma
concentration
VC
if we know the plasma concentration and we know how big the
bucket is we can
figure out how much drug is in
the body
if we have a drug where
plasma concentraiton if .004
mg/mL VD is 15 L
how much drug is in the body? - ANSWER-60 mg
.004 mg/mL x 15000 mL
how do you calculate loading dose? - ANSWER-volume
x the plasma
concentration that we are trying to reach or
therapeutic range
VCther
calculate a loading dose for IV drug A for a 60
kg individual
t1/2 75
minutes
Cther
5mg/L
, Vw
3L/kg
k0.693/ t1/2 - ANSWER-
900 mg
5mg/L x 3L/kg x
60kg
VD=180 L (because 3L/kg x
60 kg)
What orally administered loading dose would achieve a plasma
concentration of
8 ug/mL for a drug that has a volume of distribution of 10L and
65% bioavailability? (1mg=1000 ug) - ANSWER-8ug/mL x 10,000
mL = 80,000 ug =
80 mg
80/65 = x/100
X=123 mg
maintenance dose - ANSWER-the dose of drug that
maintains or keeps the
drug in the therapeutic
range
replaces drug eliminated per
unit of time
ACTUAL COMPLETE REAL EXAM QUESTIONS WITH CORRECT
DETAILED ANSWERS (VERIFIED ANSWERS) ALREADY
PASSED!! GRADED A+ /2025 BRAND NEW EXAM!!
what are the four things that the body does to a drug? -
ANSWER-1. absorbs it 2. distributes it (think about it - most
drugs don't have MOA in the stomach or GI tract, the body
distributes to where it acts)
3. biotransforms or metabolizes it
4. eliminates it
What orally administered loading dose would achieve a plasma
concentration of
25 micrograms/mL for a drug that has a VD of 30 Liters and 90%
bioavailability?
(1 mg = 1000 ug) - ANSWER-total amount of drug in the body
is 25 ug/mL x
30,000 mL = 750,000 ug =
750 mg
we need 750 mg to achieve desired plasma concentration. (25
ug/mL) given VD
(30L)
,Bioavailability is 90%, we need to give more drug than 750 mg
to achieve the desired plasma concentration, because we know
that 10% will never reach the plasma
So
750/90 =
x/100
x=833.3 mg
What rate of IV infusion is needed to maintain a drug plasma
level of 45 ug/mL in a 70 kg man if the systemic clearance of
the drug is 50 mL/min? – ANSWER-2250 ug/min
How many half lifes does it typically take before we hit
steady state
concentration? - ANSWER-usually 4-6
half lifes
What is most important to know when calculating loading
dose? – ANSWER-volume of distribution
we need to know the concentration that we are trying to reach
and the volume of distribution (how big is the bucket we are
going to put the drug into) if the bucket is big we need a bigger
loading dose
,how do you calculate the amount of drug in the body - ANSWER-
essentially it is
the volume of distribution x plasma
concentration
VC
if we know the plasma concentration and we know how big the
bucket is we can
figure out how much drug is in
the body
if we have a drug where
plasma concentraiton if .004
mg/mL VD is 15 L
how much drug is in the body? - ANSWER-60 mg
.004 mg/mL x 15000 mL
how do you calculate loading dose? - ANSWER-volume
x the plasma
concentration that we are trying to reach or
therapeutic range
VCther
calculate a loading dose for IV drug A for a 60
kg individual
t1/2 75
minutes
Cther
5mg/L
, Vw
3L/kg
k0.693/ t1/2 - ANSWER-
900 mg
5mg/L x 3L/kg x
60kg
VD=180 L (because 3L/kg x
60 kg)
What orally administered loading dose would achieve a plasma
concentration of
8 ug/mL for a drug that has a volume of distribution of 10L and
65% bioavailability? (1mg=1000 ug) - ANSWER-8ug/mL x 10,000
mL = 80,000 ug =
80 mg
80/65 = x/100
X=123 mg
maintenance dose - ANSWER-the dose of drug that
maintains or keeps the
drug in the therapeutic
range
replaces drug eliminated per
unit of time
