WGU D027 Practice Questions With
100% Correct Answers
A patient has endured several dosage adjustments of his tricyclic
antidepressant, so the provider recommends genetic testing.
Which statement correctly describes the rationale for genetic
testing?
a. The CYP2D6 gene influences metabolism of tricyclic
antidepressants and certain other drugs
b. The HER2 gene is a tumor marker that impacts metabolism of
tricyclic antidepressants
c. The BRCA2 gene influences metabolism of certain drugs and
increases the risk for breast cancer
d. The x-linked OPN1MW gene for male color blindness also
slows metabolism of certain drugs Correct Answers a. The
CYP2D6 gene influences metabolism of tricyclic
antidepressants and certain other drugs
Answer/Rationale: CYP2D6 - page 155 Box 4.3 of Chapter 4
Genes and Genetic Diseases, McCance & Huether, Unit 2,
Genes, Environmental Lifestyle, and Common Diseases. HER2
is a gene often implicated with cancer, as is BRCA2. OPN1MW
is the gene that codes for color blindness in men. Metabolism of
,25% of all prescribed drugs, including tricyclic antidepressants,
beta adrenergic receptor blockers, and neuroleptics, is
influenced by variants in a certain gene, requiring genetic testing
to reduce trial-and-error in estimating appropriate drug-dosage
levels.
As an advanced practice nurse, you want to learn more about the
CDC's initiatives relative to asthma care and management in
order to advocate for asthma sufferers at the state legislative
level. Your goal is to reduce medications costs to patients.
Which CDC recommendation supports your goal?
a. The CDC recommends that payers and employers promote
healthy workspaces to decrease environmental trigger exposures
b. The CDC recommends that providers prescribe the most cost-
efficient long-acting inhalers to lower patient co-pays
c. The CDC recommends that providers deviate from the
stepwise approach to lessen the financial impact to the patient
d. The CDC recommends that co-pays be removed for inhaled
corticosteroids and other prescribed medications Correct
Answers d. The CDC recommends that co-pays be removed for
inhaled corticosteroids and other prescribed medications
Answer/Rationale: D - The CDC recommends that co-pays be
removed for inhaled corticosteroids and other prescribed
,medications per the following link,
https://healthpayerintelligence.com/news/top-10-most-
expensive-chronic-diseases-for-healthcare-payers; Genes,
Environmental Lifestyle, and Common Diseases; Unit 2
A female patient has been recently diagnosed with invasive
ductal carcinoma. As an advanced practice nurse, you
understand that she will be undergoing a multi-faceted treatment
approach that will include one or more medications. Which
medication is considered the "gold standard" endocrine
treatment for breast cancer?
a. Fulvestrant (Faslodex), an antiestrogen indicated for
metastatic estrogen receptor-positive breast cancer in post-
menopausal women
b. Tamoxifen (Nolvadex), a prodrug that must be converted to
active metabolites in order to block estrogen receptors in breast
tissue
c. Trastuzumab (Herceptin), a monoclonal antibody approved
for HER2-positive metastatic breast cancer
d. Lapatinib (Tykerb), an oral inhibitor of HER2 tyrosine kinase
and EGFR tyrosine kinase, resulting in apoptosis and
suppression of tumor cell growth Correct Answers b.
Tamoxifen (Nolvadex), a prodrug that must be converted to
active metabolites in order to block estrogen receptors in breast
tissue
, Answer/Rationale: Tamoxifen, page 929, Chapter 82 of Lehne,
Unit 2, Human Structures for Self Defense
A patient reports a maternal family history of Lynch syndrome.
Which laboratory finding might indicate a need for further
testing for the presence of Lynch syndrome in this patient?
a. Elevated thyroid-stimulating hormone
b. Low cortisol level
c. Positive heme-occult test
d. Sputum positive for Pseudomonas Aeruginosa Correct
Answers c. Positive heme-occult test
Answer/Rationale: Positive heme-occult because Lynch
syndrome is a hereditary form of colorectal cancer and
colorectal bleeding can be a sign of cancer, per
https://www.healthypeople.gov/2020/topics-objectives/topic/gen
omics, Unit 2, Human Structures for Self Defense
Your goal as the intensive care unit coordinator is to reduce
falls. Upon review of hospital data, you find that most of the
falls are occurring in the patient population, ages 65 and older.
As a result, you coordinate a fall reduction initiative after
100% Correct Answers
A patient has endured several dosage adjustments of his tricyclic
antidepressant, so the provider recommends genetic testing.
Which statement correctly describes the rationale for genetic
testing?
a. The CYP2D6 gene influences metabolism of tricyclic
antidepressants and certain other drugs
b. The HER2 gene is a tumor marker that impacts metabolism of
tricyclic antidepressants
c. The BRCA2 gene influences metabolism of certain drugs and
increases the risk for breast cancer
d. The x-linked OPN1MW gene for male color blindness also
slows metabolism of certain drugs Correct Answers a. The
CYP2D6 gene influences metabolism of tricyclic
antidepressants and certain other drugs
Answer/Rationale: CYP2D6 - page 155 Box 4.3 of Chapter 4
Genes and Genetic Diseases, McCance & Huether, Unit 2,
Genes, Environmental Lifestyle, and Common Diseases. HER2
is a gene often implicated with cancer, as is BRCA2. OPN1MW
is the gene that codes for color blindness in men. Metabolism of
,25% of all prescribed drugs, including tricyclic antidepressants,
beta adrenergic receptor blockers, and neuroleptics, is
influenced by variants in a certain gene, requiring genetic testing
to reduce trial-and-error in estimating appropriate drug-dosage
levels.
As an advanced practice nurse, you want to learn more about the
CDC's initiatives relative to asthma care and management in
order to advocate for asthma sufferers at the state legislative
level. Your goal is to reduce medications costs to patients.
Which CDC recommendation supports your goal?
a. The CDC recommends that payers and employers promote
healthy workspaces to decrease environmental trigger exposures
b. The CDC recommends that providers prescribe the most cost-
efficient long-acting inhalers to lower patient co-pays
c. The CDC recommends that providers deviate from the
stepwise approach to lessen the financial impact to the patient
d. The CDC recommends that co-pays be removed for inhaled
corticosteroids and other prescribed medications Correct
Answers d. The CDC recommends that co-pays be removed for
inhaled corticosteroids and other prescribed medications
Answer/Rationale: D - The CDC recommends that co-pays be
removed for inhaled corticosteroids and other prescribed
,medications per the following link,
https://healthpayerintelligence.com/news/top-10-most-
expensive-chronic-diseases-for-healthcare-payers; Genes,
Environmental Lifestyle, and Common Diseases; Unit 2
A female patient has been recently diagnosed with invasive
ductal carcinoma. As an advanced practice nurse, you
understand that she will be undergoing a multi-faceted treatment
approach that will include one or more medications. Which
medication is considered the "gold standard" endocrine
treatment for breast cancer?
a. Fulvestrant (Faslodex), an antiestrogen indicated for
metastatic estrogen receptor-positive breast cancer in post-
menopausal women
b. Tamoxifen (Nolvadex), a prodrug that must be converted to
active metabolites in order to block estrogen receptors in breast
tissue
c. Trastuzumab (Herceptin), a monoclonal antibody approved
for HER2-positive metastatic breast cancer
d. Lapatinib (Tykerb), an oral inhibitor of HER2 tyrosine kinase
and EGFR tyrosine kinase, resulting in apoptosis and
suppression of tumor cell growth Correct Answers b.
Tamoxifen (Nolvadex), a prodrug that must be converted to
active metabolites in order to block estrogen receptors in breast
tissue
, Answer/Rationale: Tamoxifen, page 929, Chapter 82 of Lehne,
Unit 2, Human Structures for Self Defense
A patient reports a maternal family history of Lynch syndrome.
Which laboratory finding might indicate a need for further
testing for the presence of Lynch syndrome in this patient?
a. Elevated thyroid-stimulating hormone
b. Low cortisol level
c. Positive heme-occult test
d. Sputum positive for Pseudomonas Aeruginosa Correct
Answers c. Positive heme-occult test
Answer/Rationale: Positive heme-occult because Lynch
syndrome is a hereditary form of colorectal cancer and
colorectal bleeding can be a sign of cancer, per
https://www.healthypeople.gov/2020/topics-objectives/topic/gen
omics, Unit 2, Human Structures for Self Defense
Your goal as the intensive care unit coordinator is to reduce
falls. Upon review of hospital data, you find that most of the
falls are occurring in the patient population, ages 65 and older.
As a result, you coordinate a fall reduction initiative after
