CORRECT ANSWERS
Loop Diuretics CORRECT ANSWER Prefix "emide"
Furosemide.
Mechanism of action: Block water reabsorption in the loop of
Henle of the nephron. Increases urine output.
AE: decreased K+, decreased BP, Ototoxicity, nephrotoxicity.
Contradictions: auditory, renal impartments
During diastole, which part of the heart is filling with blood?
CORRECT ANSWER Both ventricles. Systole reflects the
perfusing pressure of the cardiovascular system where the
ventricles eject blood from the heart. Once complete, a resting
period—diastole—follows, where blood must refill the
ventricles directly from the collection that occurred in the atria.
Oxygenated blood flows through which vessel? CORRECT
ANSWER Pulmonary vein. The superior vena cava carries all
the deoxygenated blood from peripheral circulation back to the
heart where it enters the right atrium to be pumped into the right
ventricle. The right ventricle pumps to the lungs for oxygenation
via the pulmonary artery. After pulmonary circulation, the
,oxygenated blood is carried back to the heart via the pulmonary
vein.
What effect does atherosclerosis have on the development of an
aneurysm? CORRECT ANSWER Erodes the vessel
wall .Atherosclerosis, also known as the process of "hardening
of the arteries" and secondary to plaque formation, weakens the
flexibility of a blood vessel wall. Without vascular compliance,
the vessel wall becomes more rigid and susceptible to rupture
(i.e., an aneurysm).
Which complex (wave) represents the sum of all ventricular
muscle cell depolarizations? CORRECT ANSWER The QRS
wave of an electrocardiogram (ECG or EKG) represents the
largest spike in electrical activity of the heart, as ventricular
muscle cells perform the highest burden of work to pump blood
volume out of the heart in that instance.
Which factor is responsible for the hypertrophy of the
myocardium associated with hypertension? CORRECT
ANSWER Angiotensin II leads to myocardial hypertrophy, poor
myocardial compliance, and ventricular dilation through
stimulating increased cardiac preload and afterload and direct
toxicity to myocardial cells. It causes sarcomere death, abnormal
collagen matrices, and interstitial fibrosis
,Most cardiovascular developments occur between which weeks
of gestation? CORRECT ANSWER During weeks four to
seven, the primitive heart tube progresses through numerous
stages of development leading to a developed heart with distinct
atria, ventricles, and cardiac vessels.
Which compensatory mechanism is spontaneously used by
children diagnosed with tetralogy of Fallot (TOF) to relieve
hypoxic spells? CORRECT ANSWER Spontaneous squatting
helps relieve hypercyanotic events in older children through
increasing systemic vascular resistance, decreasing venous
blood return. This provides a larger amount of oxygenated blood
for the body and leads to the temporary reversal of blood
through the ventricular septal defect (VSD), which results in
increased pulmonary flow. Squatting is rarely seen clinically
because most TOF defects are diagnosed and surgically repaired
in infancy
Which condition is consistent with the cardiac defect of
transposition of the great vessels? CORRECT ANSWER The
aorta arises from the right ventricle. In transposition of the great
vessels, opposite of a normal heart, the aorta arises from the
right ventricle, and the pulmonary artery arises from the left
ventricle.
, A 26-year-old female presents to urgent care with complaints of
extreme fatigue, muscle aches, abdominal pain, numbness and
tingling in her extremities, and bloating. She explains that she
has been experiencing gastrointestinal upset after meals and has
not had a bowel movement for the past four days. She reports
using over-the-counter, anti-diarrheal products last week to
combat diarrhea. She denies having any chronic diseases. The
assessment findings include a blood pressure of 108/71 mm Hg,
pulse of 82 beats per minute, and respirations of 20 breaths per
minute. The abdomen is distended and firm. Bowel sounds are
present in all four quadrants. The patient has a steady gait,
though verbally complains of feeling weak and off balance upon
ambulation. Following antibody testing, Celiac disease is
suspected. Which follow-up tissue test, the gold standard for this
suspected diagnosis, should be ordered? CORRECT ANSWER
Endoscopy with small intestine biopsy
A 44-year-old woman has recently been diagnosed with
advanced metastatic non-small-cell lung cancer. Genetic testing
is ordered to determine if the patient's tumor has any genomic
alterations and to guide treatment decisions. A few weeks later,
the patient's test results come back positive for a genetic
mutation. The APN starts osimertinib (Tagrisso).Based on this
information, what type of genetic mutation does this patient
have? CORRECT ANSWER EGFR mutation