PHM 431 EXAM #1 QUESTIONS AND
ANSWERS
Many factors contribute to drug addiction and continued drug use. What is NOT one of
these factors? - Answer-1st order elimination kinetics (Actual factors: drug tolerance,
drug dependence, drug withdrawal)
EC50 is a measure of drug: - Answer-Potency
What protects against acetaminophen hepato (liver) toxicity? - Answer-Glutathione
(binds to NAPQI, the toxic metabolite of acetaminophen, reducing the free concentration
of this toxin)
Which of the following brain areas is NOT part of mesolimbic dopamine system? -
Answer-Hypothalamus (Brain areas that are: prefrontal cortex, ventral tegmental area,
nucleus accumbens)
Loss of sensitivity to the effects of drug due to changes in the distribution or metabolism
of that drug is called: - Answer-Pharmacokinetic tolerance (mechanisms of metabolism
or excretion are upregulated in a person who is exposed to drugs chronically)
Describe drug tolerance - Answer-Reduction in drug response after repeated drug
administration (downregulation of receptors or intracellular signaling molecules, for
example)
What is a drug that could easily cross the blood brain barrier? - Answer-Hydrophobic
drug (molecular weight = 240)
What set of drug properties is most likely to give a drug a high addiction liability? -
Answer-A non-polar dopamine agonist with a molecular weight of 300
Loss of sensitivity to effects of drug due to changes in distribution or metabolism of drug
is called: - Answer-Pharmacokinetic tolerance (mechanisms of metabolism/excretion
upregulated in chronic drug exposure)
Drug A alone has normal curve, Drug B is a flat line, and Drug A + B mimics the shape
of Drug A but is further right on the graph. What does this mean? - Answer-Drug A is a
full agonist; Drug B is a competitive receptor antagonist
Plasma protein binding of a drug is an example of: - Answer-Chemical antagonism
(drug interacts with another chemical to inactivate drug or make it inaccessible to site of
action)
The locus ceruleus is: - Answer-The vigilance center of the brain (novelty detection,
alertness)
ANSWERS
Many factors contribute to drug addiction and continued drug use. What is NOT one of
these factors? - Answer-1st order elimination kinetics (Actual factors: drug tolerance,
drug dependence, drug withdrawal)
EC50 is a measure of drug: - Answer-Potency
What protects against acetaminophen hepato (liver) toxicity? - Answer-Glutathione
(binds to NAPQI, the toxic metabolite of acetaminophen, reducing the free concentration
of this toxin)
Which of the following brain areas is NOT part of mesolimbic dopamine system? -
Answer-Hypothalamus (Brain areas that are: prefrontal cortex, ventral tegmental area,
nucleus accumbens)
Loss of sensitivity to the effects of drug due to changes in the distribution or metabolism
of that drug is called: - Answer-Pharmacokinetic tolerance (mechanisms of metabolism
or excretion are upregulated in a person who is exposed to drugs chronically)
Describe drug tolerance - Answer-Reduction in drug response after repeated drug
administration (downregulation of receptors or intracellular signaling molecules, for
example)
What is a drug that could easily cross the blood brain barrier? - Answer-Hydrophobic
drug (molecular weight = 240)
What set of drug properties is most likely to give a drug a high addiction liability? -
Answer-A non-polar dopamine agonist with a molecular weight of 300
Loss of sensitivity to effects of drug due to changes in distribution or metabolism of drug
is called: - Answer-Pharmacokinetic tolerance (mechanisms of metabolism/excretion
upregulated in chronic drug exposure)
Drug A alone has normal curve, Drug B is a flat line, and Drug A + B mimics the shape
of Drug A but is further right on the graph. What does this mean? - Answer-Drug A is a
full agonist; Drug B is a competitive receptor antagonist
Plasma protein binding of a drug is an example of: - Answer-Chemical antagonism
(drug interacts with another chemical to inactivate drug or make it inaccessible to site of
action)
The locus ceruleus is: - Answer-The vigilance center of the brain (novelty detection,
alertness)
