PHM 431 EXAM QUESTIONS AND
ANSWERS
There are several FDA approved drug treatments for nicotine addiction. Below are two
drugs and a potential mechanism of action. Which of the following drug-mechanism
pairing is correct? - Answer-Varenicline - alpha,beta2 nicotinic receptor partial agonist
Hypoxia induced increases in blood pressure is a toxic side effect of which of the
following drug treatments? - Answer-Cigarette smoke inhalation
Which of the following is not a target for the action of caffeine? - Answer-dopamine-
beta-hydroxylase
The rewarding effects produced by nicotine after chronic cigarette smoking are
mediated by: - Answer-Slowly desensitizing alpha7 nicotinic acetylcholine receptors
Pharmacologists call caffeine a "dirty drug" because it has so many potential effects.
However, when caffeine is consumed in moderate amounts such as occurs after 1-2
cups of coffee or tea, the effects of caffeine are limited to: - Answer-Blockade of
adenosine A2A receptors
Caffeine in moderate doses has been shown to improve cognitive performance. This
action of caffeine in mediated predominately by: - Answer-A1 adenosine receptors in
the cerebral cortex
Which of the following drugs is used to treat nicotine addiction? - Answer-varenicline
Smoking cigarettes can lead to nicotine addiction and signifcant health risks. Nicotine
itself is not toxic (but addictive). The cardiovascular health risk associated with cigarette
smoking includes: - Answer-Carbon monoxide induced hypoxia
Nicotine exposure increases blood pressure via an action at: - Answer-alpha3,beta4
nicotinic acetylcholine receptors on sympathetic neurons
Although there are many types of nicotinic acetylcholine receptors in the brain, the
rewarding effects produced by chronic cigarette smoking are most probably mediated
at: - Answer-presynaptic alpha7 receptors
The cognitive and memory enhancing effects of caffeine are mediated by: - Answer-A1
adenosine receptors in the cerebral cortex and hippocampus
Although pregnant women can consume moderate amounts of coffee with no risk to
their own health, the developing fetus may be a great risk for caffeine-induced toxicity
ANSWERS
There are several FDA approved drug treatments for nicotine addiction. Below are two
drugs and a potential mechanism of action. Which of the following drug-mechanism
pairing is correct? - Answer-Varenicline - alpha,beta2 nicotinic receptor partial agonist
Hypoxia induced increases in blood pressure is a toxic side effect of which of the
following drug treatments? - Answer-Cigarette smoke inhalation
Which of the following is not a target for the action of caffeine? - Answer-dopamine-
beta-hydroxylase
The rewarding effects produced by nicotine after chronic cigarette smoking are
mediated by: - Answer-Slowly desensitizing alpha7 nicotinic acetylcholine receptors
Pharmacologists call caffeine a "dirty drug" because it has so many potential effects.
However, when caffeine is consumed in moderate amounts such as occurs after 1-2
cups of coffee or tea, the effects of caffeine are limited to: - Answer-Blockade of
adenosine A2A receptors
Caffeine in moderate doses has been shown to improve cognitive performance. This
action of caffeine in mediated predominately by: - Answer-A1 adenosine receptors in
the cerebral cortex
Which of the following drugs is used to treat nicotine addiction? - Answer-varenicline
Smoking cigarettes can lead to nicotine addiction and signifcant health risks. Nicotine
itself is not toxic (but addictive). The cardiovascular health risk associated with cigarette
smoking includes: - Answer-Carbon monoxide induced hypoxia
Nicotine exposure increases blood pressure via an action at: - Answer-alpha3,beta4
nicotinic acetylcholine receptors on sympathetic neurons
Although there are many types of nicotinic acetylcholine receptors in the brain, the
rewarding effects produced by chronic cigarette smoking are most probably mediated
at: - Answer-presynaptic alpha7 receptors
The cognitive and memory enhancing effects of caffeine are mediated by: - Answer-A1
adenosine receptors in the cerebral cortex and hippocampus
Although pregnant women can consume moderate amounts of coffee with no risk to
their own health, the developing fetus may be a great risk for caffeine-induced toxicity
