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Answers 2025-2026 Edition.
- Psychosis
- What does it usually refer to - Answer - A disorder that includes impairment in reality testing
and creation of a new (idiosyncratic) reality.
- Usually refers to schizophrenia and some affective (mood) disorders
How common is Schizophrenia - Answer Relatively common: 1% of the population
Effects of Schizophrenia (5 answers) - Answer • Disturbances in thought processes
• Disturbances in perception
• Flat or inappropriate affect (emotional expression)
• Motor disturbances (catatonia)
• Impairment in routine functioning
- Positive Symptoms of Schizophrenia
- Examples - Answer - Presence of abnormal psychological and behavioral phenomena
- (hallucinations, delusions, bizarre verbose speech and behaviors)
- Negative symptoms of Schizophrenia
- Examples - Answer - Absence of normal psychological and behavioral phenomena
- (loss of content of speech, impaired emotional expression and functions, apathy(lack-of-
interest), anhedonia(inability to feel pleasure) )
What is Schizophrenia - Answer Brain disorder: enlarged ventricles (fluid-filled spaces) in
brain... usually a sign of brain cell death
, Heritability of Schizophrenia
(3 answers) - Answer • Identical (MZ) twins: 50% risk
• Fraternal (DZ) twins: 10-20% risk
• Data indicate a complicated inherited predisposition to develop schizophrenia
- Chlorpromazine in the 50's
- Chlorpromazine in 1963 - Answer -In the 50s, it was found to reduced the symptoms of
schizophrenia (but not other psychiatric disorders) this was a specific effect on psychotic
symptoms, not just sedation
- In 1963, it was proposed that the effect of antipsychotic drugs like this one was due to blocking
receptors for dopamine(DA), the compounds were DA receptor antagonists
Important Receptors for antipsychotic drugs - Answer - (Dopamine)D2 receptors are important
for drugs to help reduce schizophrenia symptoms
- (Dopamine) D1 receptors are used but less important
- Atypical antipsychotic drugs
- Examples - Answer - They are generally as effective as the typical ones, but have a lower
incidence of extrapyramidal effects(movement side-effects)(Parkinsons like side effects) .
- Thioridazine and clozapine
- Tardive dyskinesia occurance rate:
- Effects - Answer - Occurs following long-term (months to years) administration of
antipsychotic drugs in 20-30% of patients.
- Involuntary oral and facial movements, tics, grimacing
Clozapine agranulocytosis - Answer Potentially fatal blood disorder, requires patients taking
clozapine to have frequent blood tests
- Prominant symptoms of Affective mood disorders