WGU D027 EXAM AND STUDY GUIDE NEWEST 2025/2026 ACTUAL
EXAM QUESTIONS AND CORRECT DETAILED ANSWERS
Question 1
Cystic fibrosis is a genetic disorder that primarily affects which organ, leading to abnormal
secretions that impact the lungs?
A) Liver
B) Kidneys
C) Pancreas
D) Spleen
E) Adrenal glands
Correct Answer: C) Pancreas
Rationale: Cystic fibrosis affects the pancreas, causing thick secretions that can block ducts
and also significantly impact the lungs by clogging airways.
Question 2
A male patient presenting with female-like qualities may have which genetic condition
characterized by an extra X chromosome (XXY)?
A) Turner Syndrome
B) Cystic Fibrosis
C) Down Syndrome
D) Klinefelter Syndrome
E) Beta Thalassemia
Correct Answer: D) Klinefelter Syndrome
Rationale: Klinefelter syndrome is a genetic condition in males caused by the presence of an
extra X chromosome (XXY), which can lead to the development of female-like
characteristics.
Question 3
Turner Syndrome is a genetic condition affecting females and is characterized by:
A) An extra X chromosome (XXX)
B) An extra Y chromosome (XYY)
C) A missing or deformed X chromosome
D) A mutation on chromosome 23
,E) Deletion of chromosome 15
Correct Answer: C) A missing or deformed X chromosome
Rationale: Turner Syndrome occurs in females when one of the X chromosomes is missing
or partially missing, leading to various developmental and medical problems like right
hemisphere dysfunction and hearing loss.
Question 4
Beta thalassemia is a blood disorder characterized by which of the following?
A) Overproduction of red blood cells
B) A deficiency in glucose-6-phosphate dehydrogenase (G6PD)
C) Decreased or absent synthesis of beta-globin chains, leading to low hemoglobin
D) An extra X chromosome causing anemia
E) Destruction of alveolar walls
Correct Answer: C) Decreased or absent synthesis of beta-globin chains, leading to low
hemoglobin
Rationale: Beta thalassemia is a genetic disorder that reduces the production of hemoglobin,
the iron-containing protein in red blood cells that carries oxygen, due to a defect in the
beta-globin chains.
Question 5
Which medication should be avoided in a patient diagnosed with Beta Thalassemia due to the
risk of iron overload?
A) Folic acid
B) Glucocorticoids
C) Ferrous Sulfate
D) Amoxicillin
E) Spironolactone
Correct Answer: C) Ferrous Sulfate
Rationale: Patients with Beta Thalassemia can suffer from iron overload from frequent
blood transfusions and increased iron absorption. Therefore, iron supplements like Ferrous
Sulfate are contraindicated.
,Question 6
Which class of medication is directly toxic to lymphoid tissues and is often used in combination
with other agents to treat certain types of leukemia?
A) ACE inhibitors
B) Beta blockers
C) Thiazide diuretics
D) Glucocorticoids
E) SSRIs
Correct Answer: D) Glucocorticoids
Rationale: Glucocorticoids are toxic to lymphoid tissues, making them an effective
component of treatment regimens for lymphoid malignancies such as leukemia.
Question 7
What is considered a normal range for a patient's ejection fraction (EF)?
A) 30-40%
B) 40-50%
C) 55-60%
D) 65-75%
E) Less than 50%
Correct Answer: C) 55-60%
Rationale: A normal ejection fraction is typically between 55% and 60%. An EF below 50%
can be an indicator of heart failure.
Question 8
A patient with an ejection fraction of 50% would be classified as having which type of heart
failure?
A) Heart failure with reduced ejection fraction (HFrEF)
B) Heart failure with preserved ejection fraction (HFpEF)
C) Left-sided heart failure only
D) Right-sided heart failure only
E) No heart failure
Correct Answer: B) Heart failure with preserved ejection fraction (HFpEF)
, Rationale: Heart failure with a preserved ejection fraction is diagnosed when the EF is 50%
or higher. An EF of less than 40% is considered reduced.
Question 9
A patient presenting with jugular vein distension (JVD), crackles (rales) in the lungs, and an S3
heart sound is most likely experiencing which condition?
A) Right-sided heart failure
B) Emphysema
C) Left-sided heart failure
D) Addison's disease
E) Asthma
Correct Answer: C) Left-sided heart failure
Rationale: Left-sided heart failure leads to a backup of blood in the pulmonary circulation,
causing pulmonary symptoms like fluid volume overload (FVO), rales, and an S3 murmur.
It is also the most common cause of right-sided heart failure.
Question 10
Peripheral vascular symptoms such as lower extremity edema and abdominal distension are
characteristic of which type of heart failure?
A) Left-sided heart failure
B) Ischemic heart disease
C) Heart failure with preserved ejection fraction
D) Right-sided heart failure
E) Diastolic heart failure
Correct Answer: D) Right-sided heart failure
Rationale: Right-sided heart failure causes a backup of blood in the peripheral vascular
system, leading to symptoms like peripheral edema and abdominal distension.
Question 11
What is the gold standard laboratory test for diagnosing heart failure, with a result greater than
100 pg/mL being indicative of the condition?
A) Complete Blood Count (CBC)
B) Thyroid Stimulating Hormone (TSH)
EXAM QUESTIONS AND CORRECT DETAILED ANSWERS
Question 1
Cystic fibrosis is a genetic disorder that primarily affects which organ, leading to abnormal
secretions that impact the lungs?
A) Liver
B) Kidneys
C) Pancreas
D) Spleen
E) Adrenal glands
Correct Answer: C) Pancreas
Rationale: Cystic fibrosis affects the pancreas, causing thick secretions that can block ducts
and also significantly impact the lungs by clogging airways.
Question 2
A male patient presenting with female-like qualities may have which genetic condition
characterized by an extra X chromosome (XXY)?
A) Turner Syndrome
B) Cystic Fibrosis
C) Down Syndrome
D) Klinefelter Syndrome
E) Beta Thalassemia
Correct Answer: D) Klinefelter Syndrome
Rationale: Klinefelter syndrome is a genetic condition in males caused by the presence of an
extra X chromosome (XXY), which can lead to the development of female-like
characteristics.
Question 3
Turner Syndrome is a genetic condition affecting females and is characterized by:
A) An extra X chromosome (XXX)
B) An extra Y chromosome (XYY)
C) A missing or deformed X chromosome
D) A mutation on chromosome 23
,E) Deletion of chromosome 15
Correct Answer: C) A missing or deformed X chromosome
Rationale: Turner Syndrome occurs in females when one of the X chromosomes is missing
or partially missing, leading to various developmental and medical problems like right
hemisphere dysfunction and hearing loss.
Question 4
Beta thalassemia is a blood disorder characterized by which of the following?
A) Overproduction of red blood cells
B) A deficiency in glucose-6-phosphate dehydrogenase (G6PD)
C) Decreased or absent synthesis of beta-globin chains, leading to low hemoglobin
D) An extra X chromosome causing anemia
E) Destruction of alveolar walls
Correct Answer: C) Decreased or absent synthesis of beta-globin chains, leading to low
hemoglobin
Rationale: Beta thalassemia is a genetic disorder that reduces the production of hemoglobin,
the iron-containing protein in red blood cells that carries oxygen, due to a defect in the
beta-globin chains.
Question 5
Which medication should be avoided in a patient diagnosed with Beta Thalassemia due to the
risk of iron overload?
A) Folic acid
B) Glucocorticoids
C) Ferrous Sulfate
D) Amoxicillin
E) Spironolactone
Correct Answer: C) Ferrous Sulfate
Rationale: Patients with Beta Thalassemia can suffer from iron overload from frequent
blood transfusions and increased iron absorption. Therefore, iron supplements like Ferrous
Sulfate are contraindicated.
,Question 6
Which class of medication is directly toxic to lymphoid tissues and is often used in combination
with other agents to treat certain types of leukemia?
A) ACE inhibitors
B) Beta blockers
C) Thiazide diuretics
D) Glucocorticoids
E) SSRIs
Correct Answer: D) Glucocorticoids
Rationale: Glucocorticoids are toxic to lymphoid tissues, making them an effective
component of treatment regimens for lymphoid malignancies such as leukemia.
Question 7
What is considered a normal range for a patient's ejection fraction (EF)?
A) 30-40%
B) 40-50%
C) 55-60%
D) 65-75%
E) Less than 50%
Correct Answer: C) 55-60%
Rationale: A normal ejection fraction is typically between 55% and 60%. An EF below 50%
can be an indicator of heart failure.
Question 8
A patient with an ejection fraction of 50% would be classified as having which type of heart
failure?
A) Heart failure with reduced ejection fraction (HFrEF)
B) Heart failure with preserved ejection fraction (HFpEF)
C) Left-sided heart failure only
D) Right-sided heart failure only
E) No heart failure
Correct Answer: B) Heart failure with preserved ejection fraction (HFpEF)
, Rationale: Heart failure with a preserved ejection fraction is diagnosed when the EF is 50%
or higher. An EF of less than 40% is considered reduced.
Question 9
A patient presenting with jugular vein distension (JVD), crackles (rales) in the lungs, and an S3
heart sound is most likely experiencing which condition?
A) Right-sided heart failure
B) Emphysema
C) Left-sided heart failure
D) Addison's disease
E) Asthma
Correct Answer: C) Left-sided heart failure
Rationale: Left-sided heart failure leads to a backup of blood in the pulmonary circulation,
causing pulmonary symptoms like fluid volume overload (FVO), rales, and an S3 murmur.
It is also the most common cause of right-sided heart failure.
Question 10
Peripheral vascular symptoms such as lower extremity edema and abdominal distension are
characteristic of which type of heart failure?
A) Left-sided heart failure
B) Ischemic heart disease
C) Heart failure with preserved ejection fraction
D) Right-sided heart failure
E) Diastolic heart failure
Correct Answer: D) Right-sided heart failure
Rationale: Right-sided heart failure causes a backup of blood in the peripheral vascular
system, leading to symptoms like peripheral edema and abdominal distension.
Question 11
What is the gold standard laboratory test for diagnosing heart failure, with a result greater than
100 pg/mL being indicative of the condition?
A) Complete Blood Count (CBC)
B) Thyroid Stimulating Hormone (TSH)
