BCH 361 CH 4 EXAM QUESTIONS
WITH 100% CORRECT DETAILED
ANSWERS
Which of the following statements about collagen is TRUE?
a) It is a triple alpha helix.
b) It is the main component of cartilage and teeth.
c) It contains high levels of hydroxyglycine.
d) All - Answer-b
What maintains the secondary structure of a protein?
a) peptide bonds
b) hydrogen bonds
c) disulfide bonds
d) phosphodiester bonds
e) ionic bonds - Answer-b
_____ is an amyloidose disease. In amyloidoses, normally soluble proteins are _____.
a) Alzheimer disease; converted into insoluble fibers rich in α helices
b) Huntington disease; converted into soluble fibers rich in β sheets
c) Transmissible spongiform encephalopathy; converted into insoluble fibers rich in α
helices
d) Alzheimer disease; converted into soluble fibers rich in β sheets
e) Huntington disease; converted into insoluble fibers rich in β sheets - Answer-e
Which of the following statements is TRUE of the protein titin?
a) It is found in muscle cells.
b) It is the largest protein known.
c) It consists of almost 200,000 amino acids
d) Both the first and second answers are true - Answer-
Which of the following is true of PrP but not of PrPSC?
a) contains secondary structure
b) is insoluble in aqueous solution
c) links to other proteins to form aggregates
d) is not infectious
, e) None of the above - Answer-d
The protein calmodulin contains a central α helix that connects two globular regions. If
the central helix is 65 angstroms (Å) long, approximately how many amino acids are in
this α helix?
a) 3.6
b) 12
c) 43
d) 65
e) 234 - Answer-c
Peptide bonds resist rotation and are essentially planar because:
a) the peptide bond has partial double bond character.
b) hydrogen bonding between the hydrogen and a carbonyl oxygen of another peptide
bond force planarity.
c) covalent bonds resist rotation.
d) biosynthesis of peptide bonds requires an input of free energy. - Answer-a
Given the mean molecular weight of an amino acid, the molecular weight of the protein
titin would be approximately:
a) 297 kd.
b) 2.9 kd.
c) 110 kd.
d) 2970 kd.
e) 110 d. - Answer-d
A Ramachandran diagram of Ψ versus Φ angles is separated into four quadrants. In
which quadrant would you expect to find data descriptive of a β-pleated sheet?
a) top right
b) top left
c) bottom right
d) bottom left - Answer-b
An IUP is an:
a) important unfolding procedure.
b) internally unfolded protein.
c) internally unstructured protein.
d) intrinsically unfolded protein.
e) intrinsically unstructured protein. - Answer-e
Many proteins that bind DNA contain which of the following motifs?
WITH 100% CORRECT DETAILED
ANSWERS
Which of the following statements about collagen is TRUE?
a) It is a triple alpha helix.
b) It is the main component of cartilage and teeth.
c) It contains high levels of hydroxyglycine.
d) All - Answer-b
What maintains the secondary structure of a protein?
a) peptide bonds
b) hydrogen bonds
c) disulfide bonds
d) phosphodiester bonds
e) ionic bonds - Answer-b
_____ is an amyloidose disease. In amyloidoses, normally soluble proteins are _____.
a) Alzheimer disease; converted into insoluble fibers rich in α helices
b) Huntington disease; converted into soluble fibers rich in β sheets
c) Transmissible spongiform encephalopathy; converted into insoluble fibers rich in α
helices
d) Alzheimer disease; converted into soluble fibers rich in β sheets
e) Huntington disease; converted into insoluble fibers rich in β sheets - Answer-e
Which of the following statements is TRUE of the protein titin?
a) It is found in muscle cells.
b) It is the largest protein known.
c) It consists of almost 200,000 amino acids
d) Both the first and second answers are true - Answer-
Which of the following is true of PrP but not of PrPSC?
a) contains secondary structure
b) is insoluble in aqueous solution
c) links to other proteins to form aggregates
d) is not infectious
, e) None of the above - Answer-d
The protein calmodulin contains a central α helix that connects two globular regions. If
the central helix is 65 angstroms (Å) long, approximately how many amino acids are in
this α helix?
a) 3.6
b) 12
c) 43
d) 65
e) 234 - Answer-c
Peptide bonds resist rotation and are essentially planar because:
a) the peptide bond has partial double bond character.
b) hydrogen bonding between the hydrogen and a carbonyl oxygen of another peptide
bond force planarity.
c) covalent bonds resist rotation.
d) biosynthesis of peptide bonds requires an input of free energy. - Answer-a
Given the mean molecular weight of an amino acid, the molecular weight of the protein
titin would be approximately:
a) 297 kd.
b) 2.9 kd.
c) 110 kd.
d) 2970 kd.
e) 110 d. - Answer-d
A Ramachandran diagram of Ψ versus Φ angles is separated into four quadrants. In
which quadrant would you expect to find data descriptive of a β-pleated sheet?
a) top right
b) top left
c) bottom right
d) bottom left - Answer-b
An IUP is an:
a) important unfolding procedure.
b) internally unfolded protein.
c) internally unstructured protein.
d) intrinsically unfolded protein.
e) intrinsically unstructured protein. - Answer-e
Many proteins that bind DNA contain which of the following motifs?
