NSG 552 PSYCHOPHARMACOLOGY
WILKES EXAM 3 STUDY GUIDE FALL
QUESTIONS & ANSWERS(RATED
A+)
First Line Treatments for alcohol use disorder (according to Study Guide &
Dynamed) - ANSWERnaltrexone and acamprosate
Bupropions role in alcohol use disorder - ANSWERCan diminish cravings for etoh,
treat underlying anxiety/depression
Safety Risk associated with bupropion and etoh - ANSWERbupropion increases the
risk of seizures in those going through etoh withdrawal
s/s ETOH intoxication - ANSWERimpaired fine motor control, impaired judgement
and coordination, ataxic gait, poor balance, lethargy, difficulty sitting upright, difficulty
with memory and sitting upright, N/V, coma in levels 300mg/dL and over with
respiratory depression and death possible
Second Line Treatments for alcohol use disorder (according to study guide but not
dynamed) - ANSWERDisulfuram and Bupropion (not FDA approved for ETOH but
second line according to study guide)
Second Line Treatment for alcohol use disorder (according to Dynamed) -
ANSWERDisulfuram
Other off label medications for alcohol use disorder according to Dynamed -
ANSWERTopiramate, gabapentin, baclofen
Other off label medications for alcohol use disorder according to Stahl's -
ANSWERTopiramate, ondansetron
MOA of Naltrexone - ANSWEROpioid Receptor Antagonist
MOA of Acamprosate - ANSWER- weak GABAa agonist
- weak NMDA antagonist
(does not prevent withdrawal symptoms)
MOA of Disulfuram - ANSWERinhibits enzyme (aldehyde dehydrogenase) in the
liver
S/S of etoh withdrawal - ANSWERMild: insomnia, irritability, hand tremor
Moderate: autonomic hyperactivity (diaphoresis, tachycardia, HTN), fever
, Severe: seizures (12-48 hours post consumption), hallucinations, Delirium Tremens
Delirium Tremens - ANSWER48-96 hours after last etoh consumption includes
anxiety, anorexia, nausea/vomiting, psychomotor agitation
Scale used to measure etoh withdrawal - ANSWERCIWA
CIWA assesses: - ANSWERn/v, tremor, paroxysmall sweats, anxiety, agitation,
tactile disturbances, auditory disturbances, visual disturbances, headaches,
orientation
CIWA scoring - ANSWER<10=mild
10-15=moderate
>15=severe
What medication is FDA approved for both opioid use disorder and alcohol use
disorder? - ANSWERNaltrexone
MOA of Suboxone (buprenorphine and naloxone) - ANSWERpartial opioid agonist +
competitive opioid antagonist
Medication used in opioid overdose - ANSWERnaloxone
Medication used in patients with chronic pain and opioid use disorder -
ANSWERSuboxone (buprenorphine and naloxone)
Which medications for opioid use disorder can precipitate withdrawal -
ANSWERnaloxone, naltrexone, Suboxone (buprenorphine)
Which medication used to treat opioid use disorder has a "ceiling effect"? -
ANSWERBuprenorphine... increasing the dose does not result in increasing effects
Which medication is available sublingual film/tab and buccal film for opioid patients -
ANSWERSuboxone
What routes of administration exist for Naltrexone - ANSWERPO, monthly injection
(Vivitrol), implant
What is the First Line medication in maintaining abstinence after alcohol
detoxification? - ANSWERAcamprosate
What medication can safely be used to treat alcohol use disorder in patients who
keep drinking alcohol? - ANSWERAcamprosate
What medication used to treat alcohol use disorder can be safely administered to
patients with hepatitis and/or liver disease - ANSWERAcamprosate
What medication used to treat alcohol use disorder is contraindicated with severe
renal disease? - ANSWERAcamprosate
WILKES EXAM 3 STUDY GUIDE FALL
QUESTIONS & ANSWERS(RATED
A+)
First Line Treatments for alcohol use disorder (according to Study Guide &
Dynamed) - ANSWERnaltrexone and acamprosate
Bupropions role in alcohol use disorder - ANSWERCan diminish cravings for etoh,
treat underlying anxiety/depression
Safety Risk associated with bupropion and etoh - ANSWERbupropion increases the
risk of seizures in those going through etoh withdrawal
s/s ETOH intoxication - ANSWERimpaired fine motor control, impaired judgement
and coordination, ataxic gait, poor balance, lethargy, difficulty sitting upright, difficulty
with memory and sitting upright, N/V, coma in levels 300mg/dL and over with
respiratory depression and death possible
Second Line Treatments for alcohol use disorder (according to study guide but not
dynamed) - ANSWERDisulfuram and Bupropion (not FDA approved for ETOH but
second line according to study guide)
Second Line Treatment for alcohol use disorder (according to Dynamed) -
ANSWERDisulfuram
Other off label medications for alcohol use disorder according to Dynamed -
ANSWERTopiramate, gabapentin, baclofen
Other off label medications for alcohol use disorder according to Stahl's -
ANSWERTopiramate, ondansetron
MOA of Naltrexone - ANSWEROpioid Receptor Antagonist
MOA of Acamprosate - ANSWER- weak GABAa agonist
- weak NMDA antagonist
(does not prevent withdrawal symptoms)
MOA of Disulfuram - ANSWERinhibits enzyme (aldehyde dehydrogenase) in the
liver
S/S of etoh withdrawal - ANSWERMild: insomnia, irritability, hand tremor
Moderate: autonomic hyperactivity (diaphoresis, tachycardia, HTN), fever
, Severe: seizures (12-48 hours post consumption), hallucinations, Delirium Tremens
Delirium Tremens - ANSWER48-96 hours after last etoh consumption includes
anxiety, anorexia, nausea/vomiting, psychomotor agitation
Scale used to measure etoh withdrawal - ANSWERCIWA
CIWA assesses: - ANSWERn/v, tremor, paroxysmall sweats, anxiety, agitation,
tactile disturbances, auditory disturbances, visual disturbances, headaches,
orientation
CIWA scoring - ANSWER<10=mild
10-15=moderate
>15=severe
What medication is FDA approved for both opioid use disorder and alcohol use
disorder? - ANSWERNaltrexone
MOA of Suboxone (buprenorphine and naloxone) - ANSWERpartial opioid agonist +
competitive opioid antagonist
Medication used in opioid overdose - ANSWERnaloxone
Medication used in patients with chronic pain and opioid use disorder -
ANSWERSuboxone (buprenorphine and naloxone)
Which medications for opioid use disorder can precipitate withdrawal -
ANSWERnaloxone, naltrexone, Suboxone (buprenorphine)
Which medication used to treat opioid use disorder has a "ceiling effect"? -
ANSWERBuprenorphine... increasing the dose does not result in increasing effects
Which medication is available sublingual film/tab and buccal film for opioid patients -
ANSWERSuboxone
What routes of administration exist for Naltrexone - ANSWERPO, monthly injection
(Vivitrol), implant
What is the First Line medication in maintaining abstinence after alcohol
detoxification? - ANSWERAcamprosate
What medication can safely be used to treat alcohol use disorder in patients who
keep drinking alcohol? - ANSWERAcamprosate
What medication used to treat alcohol use disorder can be safely administered to
patients with hepatitis and/or liver disease - ANSWERAcamprosate
What medication used to treat alcohol use disorder is contraindicated with severe
renal disease? - ANSWERAcamprosate
