Page 1 of 289
AAFP BOARD EXAM NEWEST 2025 ACTUAL EXAM
TEST BANK| AAFP BOARD REVIEW WITH
COMPLETE 950 REAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS (VERIFIED
ANSWERS) GRADED A+
A 69-year-old male with type 2 diabetes mellitus, obesity, and a history
of coronary artery disease sees you for follow-up of his diabetes. His
hemoglobin A1c has increased to 8.7% despite therapy with metformin
(Glucophage), 1000 mg twice daily, and insulin glargine (Lantus).Which
one of the following additional medications would be most effective for
reducing his blood glucose level and lowering his risk of cardiovascular
events?
A. Exenatide (Byetta)
B. Glipizide (Glucotrol)
C. Liraglutide (Victoza)
D. Rosiglitazone (Avandia) - Correct Answer - C. Liraglutide (Victoza)
Only GLP-1 to reduce risk of cardiovascular events
A 75 yo M presents to the clinic with dizziness. He reports no head
trauma or weakness. He feels his hearing has been worse in his R ear
since the dizziness started. VS WNL, L-beating horizontal nystagmus
observed. Which of the following is most likely diagnosis?
A. BPPV
B. Labyrinthitis
C. Orthostatic hypotension
pg. 1
,Page 2 of 289
D. Vestibular migraine - Correct Answer - B. labyrinthitis
A previously healthy 45 yo female comes in with upper abdominal pain
and dysphagia. An upper GI series shows no significant reflux. On EGD
esophagus has a ringed appearance and biopsy shows >15 eosinophils.
Helicobacter pylori testing is negative. She's not on any meds. What is
the best initial treatment?
A. Budesonide oral suspension, 1 mg BID
B. Fexofenadine, 180 mg qD
C. Pantoprazole, 40 mg qD
D. Prednisone, 40 mg qD x 7 days
E. Ranitidine, 150 mg qD - Correct Answer - A, Budesonide for
localized steroids
A 72 yo female presents for routine health exam. Which of these
medications puts her at risk for osteoporosis?
A. Atorvastatin
B. HCTZ
C. Metformin
D. Phenytoin - Correct Answer - D. Phenytoin
In asymptomatic patients with sarcoidosis, which one of the following
organ systems should be examined yearly to detect extrapulmonary
manifestations of the disease?
A. Cardiac
pg. 2
,Page 3 of 289
B. Neurologic
C. Ocular
D. Integumentary - Correct Answer - Ocular (sarcoid uveitis)
Which one of the following coexisting conditions could require the use
of a much higher than expected dose of levothyroxine?
A. CKD
B. DM
C. H. pylori gastritis
D. Hep C infection - Correct Answer - C. H pylori because irritates
stomach lining and impairs the absorption of levothyroxine
This also applies with chronic PPI use
A 46 yo F has a 3 day hx of dysuria with burning, frequency, and
urgency. She reports no fever, weakness, or hematuria. Her chronic
health problems include obesity and prediabetes. She has no known
allergies. Which one of the following would be the most appropriate
treatment regimen for this patient?
A. Ibuprofen x 3 days
B. TMP/SMX (Bactrim) x 3 days
C. Cipro x 7 days
D. Levofloxacin (Levaquin) x 7 days - Correct Answer - B. TMP SMX,
acute uncomplicated cystitis treatment is for 3 days
Of note: If using Macrobid, it should be for 5 days
pg. 3
, Page 4 of 289
A 13 yo F sees you for the first time. Her mother has brought her in
because the patient has never menstruated. She feels well and has no
other health concerns. Her medical history is unremarkable, and she
takes no medications. A physical exam is significant for the absence of
both breast development and pubic hair. Her height is below the 2nd
percentile and her weight is 6th percentile. Beta-hCG, prolactin, and
TSH levels all normal. LH and FSH levels are elevated. Which one of
the following tests would you order at this point?
A. A trial of OCPs
B. A serum testosterone level
C. Pelvis u/s
D. Karyotyping - Correct Answer - D. Karyotyping
A 22 yo G1P0 with a history of homelessness and recent IV drug use
presents for prenatal care. Mantoux tuberculin testing is performed and
produces 20 mm of induration. She had a negative TB test 1 year ago. A
CXR is normal. You decide to treat her with isoniazid for latent TB
infection. Which one of the following should also be given to prevent
the development of peripheral neuropathy?
A. Folate
B. Vitamin B6
C. Vitamin D
D. Cymbalta - Correct Answer - B. Vitamin B6
A 72 yo F comes to your office to discuss newly diagnosed peripheral
artery disease. She has a hx of T2DM long-standing, HTN, HLD. Her
current meds including atorvastatin 80 mg, metformin XR 2000 daily,
pg. 4
AAFP BOARD EXAM NEWEST 2025 ACTUAL EXAM
TEST BANK| AAFP BOARD REVIEW WITH
COMPLETE 950 REAL EXAM QUESTIONS AND
CORRECT DETAILED ANSWERS (VERIFIED
ANSWERS) GRADED A+
A 69-year-old male with type 2 diabetes mellitus, obesity, and a history
of coronary artery disease sees you for follow-up of his diabetes. His
hemoglobin A1c has increased to 8.7% despite therapy with metformin
(Glucophage), 1000 mg twice daily, and insulin glargine (Lantus).Which
one of the following additional medications would be most effective for
reducing his blood glucose level and lowering his risk of cardiovascular
events?
A. Exenatide (Byetta)
B. Glipizide (Glucotrol)
C. Liraglutide (Victoza)
D. Rosiglitazone (Avandia) - Correct Answer - C. Liraglutide (Victoza)
Only GLP-1 to reduce risk of cardiovascular events
A 75 yo M presents to the clinic with dizziness. He reports no head
trauma or weakness. He feels his hearing has been worse in his R ear
since the dizziness started. VS WNL, L-beating horizontal nystagmus
observed. Which of the following is most likely diagnosis?
A. BPPV
B. Labyrinthitis
C. Orthostatic hypotension
pg. 1
,Page 2 of 289
D. Vestibular migraine - Correct Answer - B. labyrinthitis
A previously healthy 45 yo female comes in with upper abdominal pain
and dysphagia. An upper GI series shows no significant reflux. On EGD
esophagus has a ringed appearance and biopsy shows >15 eosinophils.
Helicobacter pylori testing is negative. She's not on any meds. What is
the best initial treatment?
A. Budesonide oral suspension, 1 mg BID
B. Fexofenadine, 180 mg qD
C. Pantoprazole, 40 mg qD
D. Prednisone, 40 mg qD x 7 days
E. Ranitidine, 150 mg qD - Correct Answer - A, Budesonide for
localized steroids
A 72 yo female presents for routine health exam. Which of these
medications puts her at risk for osteoporosis?
A. Atorvastatin
B. HCTZ
C. Metformin
D. Phenytoin - Correct Answer - D. Phenytoin
In asymptomatic patients with sarcoidosis, which one of the following
organ systems should be examined yearly to detect extrapulmonary
manifestations of the disease?
A. Cardiac
pg. 2
,Page 3 of 289
B. Neurologic
C. Ocular
D. Integumentary - Correct Answer - Ocular (sarcoid uveitis)
Which one of the following coexisting conditions could require the use
of a much higher than expected dose of levothyroxine?
A. CKD
B. DM
C. H. pylori gastritis
D. Hep C infection - Correct Answer - C. H pylori because irritates
stomach lining and impairs the absorption of levothyroxine
This also applies with chronic PPI use
A 46 yo F has a 3 day hx of dysuria with burning, frequency, and
urgency. She reports no fever, weakness, or hematuria. Her chronic
health problems include obesity and prediabetes. She has no known
allergies. Which one of the following would be the most appropriate
treatment regimen for this patient?
A. Ibuprofen x 3 days
B. TMP/SMX (Bactrim) x 3 days
C. Cipro x 7 days
D. Levofloxacin (Levaquin) x 7 days - Correct Answer - B. TMP SMX,
acute uncomplicated cystitis treatment is for 3 days
Of note: If using Macrobid, it should be for 5 days
pg. 3
, Page 4 of 289
A 13 yo F sees you for the first time. Her mother has brought her in
because the patient has never menstruated. She feels well and has no
other health concerns. Her medical history is unremarkable, and she
takes no medications. A physical exam is significant for the absence of
both breast development and pubic hair. Her height is below the 2nd
percentile and her weight is 6th percentile. Beta-hCG, prolactin, and
TSH levels all normal. LH and FSH levels are elevated. Which one of
the following tests would you order at this point?
A. A trial of OCPs
B. A serum testosterone level
C. Pelvis u/s
D. Karyotyping - Correct Answer - D. Karyotyping
A 22 yo G1P0 with a history of homelessness and recent IV drug use
presents for prenatal care. Mantoux tuberculin testing is performed and
produces 20 mm of induration. She had a negative TB test 1 year ago. A
CXR is normal. You decide to treat her with isoniazid for latent TB
infection. Which one of the following should also be given to prevent
the development of peripheral neuropathy?
A. Folate
B. Vitamin B6
C. Vitamin D
D. Cymbalta - Correct Answer - B. Vitamin B6
A 72 yo F comes to your office to discuss newly diagnosed peripheral
artery disease. She has a hx of T2DM long-standing, HTN, HLD. Her
current meds including atorvastatin 80 mg, metformin XR 2000 daily,
pg. 4
