Advanced Practice Nurse Prescribers final
exam actual questions and answers
2025/2026
Nurse practitioner prescriptive authority is regulated by who? - The State Board of Nursing for Each
State
What is the benefits of having an APRN prescriber? - APRN's care for patients more holistically and
include patients in making decisions regarding their care
What does clinical judgement in prescribing include? - Factoring in the cost of the particular
What is included in the criteria for choosing and effective drug for a disorder? - Consulting nationally
recognized guidelines for disease management
NP's thrive under the new health-care reform because of what? - NP's have the ability to control
care cost and improve patient outcome
Nutritional intake and lab results reflect hypoalbuminemia; why is this important for prescribers? -
The Distribution of drugs to target tissues may be affected
Drugs that have an significant first-pass effect what? - they are rapidly metabolized by the liver and
may have little if any desired action
The route of excretion of a volatile drug will likely be? - Lungs
Medroxyprogesterone (Depo Provera) is prescribed IM to create storage reservoir of the drug. What
are storage reserviors> - Increased the length of time a drug is available and active
Why is Cephalexin given every 8 hours? What knowledge of the drug does the NP know? - Half Life
Azithromycin doing requires that the first day's doing be twice those of the other four day; This is
considered a loading does. What is a loading dose? - Rapidly actives drug levels in the therapeutic
range
B. Hydrochlorothiazide
C. Losartan
D. Amlodipine
Explanation: Losartan is an ARB, which does not cause cough like ACE inhibitors.
Page 1
, The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect
is the: - Onset of action
Phenytoin required that a trough level be drawn. When and why are peak and trough levels are
done - To determine if a d rug is in the therapeutic range
Drugs that are receptor agonists may demonstrate what property? - Concentrations will produce an
adverse effect
Factors that affect gastric drug absorption include - Lipid solubility of the drug
Drugs that are receptors antagonists, such as beta-blockers, may cause what? - An exaggerated
response if abrupt discontinues
Drug administration via IV:
1) need to be lipid soluble in order to absorb easily
2) Begin distribution in the body immediately
3) Are easily absorbed if they are nonionized
4) May use pinocytosis to be absorbed - Are easily absorbed if they are nonionized
What is the combination effect when a medication is added to a regimen for a synergistic effect? -
Greater than the sum of the effects of each drug individually
Which of the following statements about bioavailability is true?
1) Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
2) brands of a drug have the same bioavailability.
3) Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
4) Combining an active drug with an inert substance does not affect bioavailability. - Bioavailability
issues are especially important for drugs with narrow therapeutic
Which of the following statements about the major distribution barriers (blood-brain or fetal-
placental) is true?
1) Water soluble and ionized drugs cross these barriers rapidly.
2) The blood-brain barrier slows the entry of many drugs into and from brain cells.
3) The fetal-placental barrier protects the fetus from drugs taken by the mother.
4) Lipid-soluble drugs do not pass these barriers and are safe for pregnant women - The blood-brain
barrier slows the entry of many drugs into and from brain cells.
What is the purpose of phase I and phase II of metabolism in the liver? - Change drug molecules to
a form that an excretory organ can excrete
B. Hydrochlorothiazide
C. Losartan
D. Amlodipine
Explanation: Losartan is an ARB, which does not cause cough like ACE inhibitors.
Page 2
exam actual questions and answers
2025/2026
Nurse practitioner prescriptive authority is regulated by who? - The State Board of Nursing for Each
State
What is the benefits of having an APRN prescriber? - APRN's care for patients more holistically and
include patients in making decisions regarding their care
What does clinical judgement in prescribing include? - Factoring in the cost of the particular
What is included in the criteria for choosing and effective drug for a disorder? - Consulting nationally
recognized guidelines for disease management
NP's thrive under the new health-care reform because of what? - NP's have the ability to control
care cost and improve patient outcome
Nutritional intake and lab results reflect hypoalbuminemia; why is this important for prescribers? -
The Distribution of drugs to target tissues may be affected
Drugs that have an significant first-pass effect what? - they are rapidly metabolized by the liver and
may have little if any desired action
The route of excretion of a volatile drug will likely be? - Lungs
Medroxyprogesterone (Depo Provera) is prescribed IM to create storage reservoir of the drug. What
are storage reserviors> - Increased the length of time a drug is available and active
Why is Cephalexin given every 8 hours? What knowledge of the drug does the NP know? - Half Life
Azithromycin doing requires that the first day's doing be twice those of the other four day; This is
considered a loading does. What is a loading dose? - Rapidly actives drug levels in the therapeutic
range
B. Hydrochlorothiazide
C. Losartan
D. Amlodipine
Explanation: Losartan is an ARB, which does not cause cough like ACE inhibitors.
Page 1
, The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect
is the: - Onset of action
Phenytoin required that a trough level be drawn. When and why are peak and trough levels are
done - To determine if a d rug is in the therapeutic range
Drugs that are receptor agonists may demonstrate what property? - Concentrations will produce an
adverse effect
Factors that affect gastric drug absorption include - Lipid solubility of the drug
Drugs that are receptors antagonists, such as beta-blockers, may cause what? - An exaggerated
response if abrupt discontinues
Drug administration via IV:
1) need to be lipid soluble in order to absorb easily
2) Begin distribution in the body immediately
3) Are easily absorbed if they are nonionized
4) May use pinocytosis to be absorbed - Are easily absorbed if they are nonionized
What is the combination effect when a medication is added to a regimen for a synergistic effect? -
Greater than the sum of the effects of each drug individually
Which of the following statements about bioavailability is true?
1) Bioavailability issues are especially important for drugs with narrow therapeutic
ranges or sustained-release mechanisms.
2) brands of a drug have the same bioavailability.
3) Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
4) Combining an active drug with an inert substance does not affect bioavailability. - Bioavailability
issues are especially important for drugs with narrow therapeutic
Which of the following statements about the major distribution barriers (blood-brain or fetal-
placental) is true?
1) Water soluble and ionized drugs cross these barriers rapidly.
2) The blood-brain barrier slows the entry of many drugs into and from brain cells.
3) The fetal-placental barrier protects the fetus from drugs taken by the mother.
4) Lipid-soluble drugs do not pass these barriers and are safe for pregnant women - The blood-brain
barrier slows the entry of many drugs into and from brain cells.
What is the purpose of phase I and phase II of metabolism in the liver? - Change drug molecules to
a form that an excretory organ can excrete
B. Hydrochlorothiazide
C. Losartan
D. Amlodipine
Explanation: Losartan is an ARB, which does not cause cough like ACE inhibitors.
Page 2
