NURS611|NURS 611 ADVANCED PATHOPHYSIOLOGY EXAM 2/NEWEST U
DATE ALREADY A+ GRADED WITH EXPERT FEEDBACK |BRAND NEW!!
Study online at https://quizlet.com/_h8b7uy
1. SIADH (syndrome of inappropriate antidiuretic hormone)
Causes
S/S
Treatment: *Over secretion of ADH, Kidneys retain water causing hypervolemia
(dilute sodium- hyponatremia)
CAUSES- cancers, lung cancer, duodenum, etc
Infection in lungs or CNS -> pneumonia, meningitis,
AVP gene mutation, any surgerys
medication- Chlopropamide (oral antidiabetic)
S/S- THIRSTY, DEC urine (very concentrated) , anoerxia, (not hungry/uncomfort-
able) fluid overload, dyspnea fatigue vomiting,
hyponatremia, confusion, seizures
Treatment - Treat hyponatremia
2. Diabetes Insuipidus (DI)
Patho
Causes
S/S
Treatment: *DECREASED secretion of ADH,
diluted and excessive urine output, (concentrated -> Hypernatremia, INC plasma
osmalality),
CAUSES- ** Nephrogenic - problems with the kidneys- Genetic (Vasopressin &
Aquaphorin genes),
diseases- amyloidosis & pylenephritis
Drug- lithium carbonate (can damage kidney tubules)
** Neurogenic - lesions or trauma to hypothalamus, posterior pituitary, TBI compli-
cations
Pregnancy- body produces vasopressinase which causes ADH to break down
(decrease)
S/S- polydispisa (extreme thirst), Inc Urine output (Polyuria) diluted, hypotension,
Treatment- If tolerable, Drink alot of water to correct the problem
3. Antidiuretic Hormone
Where is it produced?
, NURS611|NURS 611 ADVANCED PATHOPHYSIOLOGY EXAM 2/NEWEST U
DATE ALREADY A+ GRADED WITH EXPERT FEEDBACK |BRAND NEW!!
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Where is it stored/secreted?
Normal function: Produced by the hypothalamus
secreted and stored by the posterior pituitary
regulates the amount of water in the body
(can also constrict blood vessels and also called vasopressin)
4. Hypopituitarism: (Disease of the anterior pituitary)
Cause- ischemia/infarction, edema, adenoma, aneyursm of the pituitary - pituitary
enlarges due to edema which causes more damage (pituitary is in an enclosed
space) -> Tiusse damage, decreased blood supply, fibrosis
Dec in all pituitary hormones- (Panhypopituitarism)
ACTH - Adrenocorticotropic
TSH- thyroid stimulating hormone
FSH & LH follicle stimulating & Lutenizing
GH- Growth hormone
5. Oxytocin Toxicity / Oxytocin Insufficiency: Disease of posterior pituitary
Hyper secretion- Toxicity
Hypo secretion- Insufficiency
6. ACTH Deficiency (Hypopituitarism)
Adrenocorticotropic deficiency: N/V, weakness, lack of energy
HYPOGLYCEMIA, hypocortisol, low urine
due to hypocortisol insulin sensitivity is increased due to less glycogen stores/ less
glucogensis
Can be life threatening
Low aldosterone (RAAS can help)
Low urine output
7. TSH Deficiency (hypopituitarism)
Thyroid Stimulating Hormone Deficiency: Same as hypothyroidism
Cold intolerance, Myxedema (wax appearance of swelled skin), Slowed metabolic
rate (inc weight gain?),
contipation, dry skin, fatigue
8. FSH & LH deficiency (Hypopituitarism)
Follicle Stimulating & Luteinizing deficiency: Hair loss, Low libido,
Amenorrhea (absence of menstruation)
Impotence in men (inability to achieve erection)
Atrophy of sex hormones (Atrophy-degenerte)
dry, thinning of vaginal tissue
, NURS611|NURS 611 ADVANCED PATHOPHYSIOLOGY EXAM 2/NEWEST U
DATE ALREADY A+ GRADED WITH EXPERT FEEDBACK |BRAND NEW!!
Study online at https://quizlet.com/_h8b7uy
9. GH Genetic deficiency in kids (GENES): GH, GHRH, IGF 1
10. GH insufficiency (Hypopituitarism)
Growth Hormone insufficiency: Growth failure,
Fasting hypoglycemia
INC body fat, DEC muscle mass,
osteoporosis, dry skin, decreased swelling,
Dyslipidemia/atherosclerosis - early mortality
11. hyperpituitarism (Anterior pituitary): Causes- Usually by a pituitary adenoma
(benign tumor) or hyperplasia - overgrowth of tissue
some genetic cases
OVERSECRETION of anterior pituitary hormones-
ACTH
GH
FS & LH
TSH
12. Impingement of adenoma on anterior pituitary gland (hyperpituitarism)
What does it cause?: Adenoma in the enclosed space pushes on other structures
Such as - OPTIC CHIASMA - cause vision problems
Caveral Sinus Nerves - Sinus problems?
13. Growth Hormone (GH) Hypersecretion
(Hyperpituitarism): excessive levels of GH & IGF1
Usually occurs SLOWLY and can be lethal cuasing
heart disease, HTN, CAD, diabetes, and cancer
-Hyperglycemia - inc glycogenesis (glycogen formed from sugar)
Adipose tissue inflammation-Adipogensis(fat deposits)
HTN- cardiomyapthy, arrythmias
Inc phosphate absorption
Enlarged tongue, deformities from excessive growth,
excessive sweat/body odor
14. Hyper secretion of Growth Hormone in Children: Excessive growth
If Epiphyseal plates are still open it can cause GIGANTISM
*Epiphyseal plates open during growth spirts and usually close after puberty?
15. Hyperprolactinemia (Hyperpituitarism): caused by adenoma of anterior pitu-
itary
Other causes- tricyclic antidepressants, renal failure, PCOS, breast stimulation,
DATE ALREADY A+ GRADED WITH EXPERT FEEDBACK |BRAND NEW!!
Study online at https://quizlet.com/_h8b7uy
1. SIADH (syndrome of inappropriate antidiuretic hormone)
Causes
S/S
Treatment: *Over secretion of ADH, Kidneys retain water causing hypervolemia
(dilute sodium- hyponatremia)
CAUSES- cancers, lung cancer, duodenum, etc
Infection in lungs or CNS -> pneumonia, meningitis,
AVP gene mutation, any surgerys
medication- Chlopropamide (oral antidiabetic)
S/S- THIRSTY, DEC urine (very concentrated) , anoerxia, (not hungry/uncomfort-
able) fluid overload, dyspnea fatigue vomiting,
hyponatremia, confusion, seizures
Treatment - Treat hyponatremia
2. Diabetes Insuipidus (DI)
Patho
Causes
S/S
Treatment: *DECREASED secretion of ADH,
diluted and excessive urine output, (concentrated -> Hypernatremia, INC plasma
osmalality),
CAUSES- ** Nephrogenic - problems with the kidneys- Genetic (Vasopressin &
Aquaphorin genes),
diseases- amyloidosis & pylenephritis
Drug- lithium carbonate (can damage kidney tubules)
** Neurogenic - lesions or trauma to hypothalamus, posterior pituitary, TBI compli-
cations
Pregnancy- body produces vasopressinase which causes ADH to break down
(decrease)
S/S- polydispisa (extreme thirst), Inc Urine output (Polyuria) diluted, hypotension,
Treatment- If tolerable, Drink alot of water to correct the problem
3. Antidiuretic Hormone
Where is it produced?
, NURS611|NURS 611 ADVANCED PATHOPHYSIOLOGY EXAM 2/NEWEST U
DATE ALREADY A+ GRADED WITH EXPERT FEEDBACK |BRAND NEW!!
Study online at https://quizlet.com/_h8b7uy
Where is it stored/secreted?
Normal function: Produced by the hypothalamus
secreted and stored by the posterior pituitary
regulates the amount of water in the body
(can also constrict blood vessels and also called vasopressin)
4. Hypopituitarism: (Disease of the anterior pituitary)
Cause- ischemia/infarction, edema, adenoma, aneyursm of the pituitary - pituitary
enlarges due to edema which causes more damage (pituitary is in an enclosed
space) -> Tiusse damage, decreased blood supply, fibrosis
Dec in all pituitary hormones- (Panhypopituitarism)
ACTH - Adrenocorticotropic
TSH- thyroid stimulating hormone
FSH & LH follicle stimulating & Lutenizing
GH- Growth hormone
5. Oxytocin Toxicity / Oxytocin Insufficiency: Disease of posterior pituitary
Hyper secretion- Toxicity
Hypo secretion- Insufficiency
6. ACTH Deficiency (Hypopituitarism)
Adrenocorticotropic deficiency: N/V, weakness, lack of energy
HYPOGLYCEMIA, hypocortisol, low urine
due to hypocortisol insulin sensitivity is increased due to less glycogen stores/ less
glucogensis
Can be life threatening
Low aldosterone (RAAS can help)
Low urine output
7. TSH Deficiency (hypopituitarism)
Thyroid Stimulating Hormone Deficiency: Same as hypothyroidism
Cold intolerance, Myxedema (wax appearance of swelled skin), Slowed metabolic
rate (inc weight gain?),
contipation, dry skin, fatigue
8. FSH & LH deficiency (Hypopituitarism)
Follicle Stimulating & Luteinizing deficiency: Hair loss, Low libido,
Amenorrhea (absence of menstruation)
Impotence in men (inability to achieve erection)
Atrophy of sex hormones (Atrophy-degenerte)
dry, thinning of vaginal tissue
, NURS611|NURS 611 ADVANCED PATHOPHYSIOLOGY EXAM 2/NEWEST U
DATE ALREADY A+ GRADED WITH EXPERT FEEDBACK |BRAND NEW!!
Study online at https://quizlet.com/_h8b7uy
9. GH Genetic deficiency in kids (GENES): GH, GHRH, IGF 1
10. GH insufficiency (Hypopituitarism)
Growth Hormone insufficiency: Growth failure,
Fasting hypoglycemia
INC body fat, DEC muscle mass,
osteoporosis, dry skin, decreased swelling,
Dyslipidemia/atherosclerosis - early mortality
11. hyperpituitarism (Anterior pituitary): Causes- Usually by a pituitary adenoma
(benign tumor) or hyperplasia - overgrowth of tissue
some genetic cases
OVERSECRETION of anterior pituitary hormones-
ACTH
GH
FS & LH
TSH
12. Impingement of adenoma on anterior pituitary gland (hyperpituitarism)
What does it cause?: Adenoma in the enclosed space pushes on other structures
Such as - OPTIC CHIASMA - cause vision problems
Caveral Sinus Nerves - Sinus problems?
13. Growth Hormone (GH) Hypersecretion
(Hyperpituitarism): excessive levels of GH & IGF1
Usually occurs SLOWLY and can be lethal cuasing
heart disease, HTN, CAD, diabetes, and cancer
-Hyperglycemia - inc glycogenesis (glycogen formed from sugar)
Adipose tissue inflammation-Adipogensis(fat deposits)
HTN- cardiomyapthy, arrythmias
Inc phosphate absorption
Enlarged tongue, deformities from excessive growth,
excessive sweat/body odor
14. Hyper secretion of Growth Hormone in Children: Excessive growth
If Epiphyseal plates are still open it can cause GIGANTISM
*Epiphyseal plates open during growth spirts and usually close after puberty?
15. Hyperprolactinemia (Hyperpituitarism): caused by adenoma of anterior pitu-
itary
Other causes- tricyclic antidepressants, renal failure, PCOS, breast stimulation,
