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PATIENT CARE FINAL EXAM SUMMARY NEWEST VERSION -
2025/2026- 100+ QUESTIONS AND VERIFIED ANSWERS 100%
CORRECT GUARANTEED SUCCESS
Why is tinnitus a symptom of ASA OD?
possibly because COX and NA/K ATPase are inhibited in the ear
Why is hyperthermia a peri-mortem presentation of an ASA OD?
due to uncoupling of oxidative phosphorylation
In early stages of an ASA OD, respiratory alkalosis will occur. In later stages
metabolic acidosis starts to occur. Can you explain the mechanism of this as well
as the presenting symptoms?
Respiratory Alkalosis: Salicylates stimulate the medullary respiratory center,
presenting sign: Kussmaul respirations
Metabolic Acidosis: Salicylates enter the cells and poison mitochondria resulting in
metabolic acidosis. Signs include Ketosis and hyperthermia
How is acetaminophen metabolized?
Metabolized into a toxic metabolite called NAPQI in the liver
What are presenting signs of an ASA OD?
Hyperthermia, altered LOC, confusion, seizures, non-cardiogenic pulmonary
edema, and shock
What is the recommended maximum therapeutic dose of ASA?
4g/24 hours about 150mg/kg
How does the body process ASA? What are signs of an OD that correlate with this?
through the renal system. Renal failure and severe hepatic dysfunction
, 2
What function does ASA interfere with in an OD?
ASA interferes with cellular respiration
Why would someone who has ODed on ASA be presenting with tachypnea and
hypernea?
causes central stimulation of respiratory drive
How is NAPQI detoxified?
Using glutathione- a substance produced in the liver
What is the lethal dose of Acetaminophen?
140-160mg/kg
What is the mechanism of an acetaminophen OD?
Glutathione supplies are depleted and NAPQI remains in its toxic form in the liver
causing hepatocyte damage and liver failure/ death
What are signs and symptoms of an acetaminophen OD after several hours?
possibly vomiting but may have no symptoms at all
What are signs and symptoms of an acetaminophen OD after 24-72 hours?
Nausea, vomiting, abdominal pain/ cramps, abnormal liver function
What are the signs and symptoms of an acetaminophen OD after 3-4 days?
lots of vomiting, jaundice, bleeding in GI or GU, possible kidney failure, pancreas
may be inflammed
What are signs and symptoms of an acetaminophen OD in its final stage?
Abdominal swelling, abdominal pain, hepatic necrosis
What are treatments and their timeline to treat an acetaminophen OD?
Activated charcoal within the first 4 hours, Mucomyst (Acetylcysteine) within 24
hours, liver/kidney transplant
PATIENT CARE FINAL EXAM SUMMARY NEWEST VERSION -
2025/2026- 100+ QUESTIONS AND VERIFIED ANSWERS 100%
CORRECT GUARANTEED SUCCESS
Why is tinnitus a symptom of ASA OD?
possibly because COX and NA/K ATPase are inhibited in the ear
Why is hyperthermia a peri-mortem presentation of an ASA OD?
due to uncoupling of oxidative phosphorylation
In early stages of an ASA OD, respiratory alkalosis will occur. In later stages
metabolic acidosis starts to occur. Can you explain the mechanism of this as well
as the presenting symptoms?
Respiratory Alkalosis: Salicylates stimulate the medullary respiratory center,
presenting sign: Kussmaul respirations
Metabolic Acidosis: Salicylates enter the cells and poison mitochondria resulting in
metabolic acidosis. Signs include Ketosis and hyperthermia
How is acetaminophen metabolized?
Metabolized into a toxic metabolite called NAPQI in the liver
What are presenting signs of an ASA OD?
Hyperthermia, altered LOC, confusion, seizures, non-cardiogenic pulmonary
edema, and shock
What is the recommended maximum therapeutic dose of ASA?
4g/24 hours about 150mg/kg
How does the body process ASA? What are signs of an OD that correlate with this?
through the renal system. Renal failure and severe hepatic dysfunction
, 2
What function does ASA interfere with in an OD?
ASA interferes with cellular respiration
Why would someone who has ODed on ASA be presenting with tachypnea and
hypernea?
causes central stimulation of respiratory drive
How is NAPQI detoxified?
Using glutathione- a substance produced in the liver
What is the lethal dose of Acetaminophen?
140-160mg/kg
What is the mechanism of an acetaminophen OD?
Glutathione supplies are depleted and NAPQI remains in its toxic form in the liver
causing hepatocyte damage and liver failure/ death
What are signs and symptoms of an acetaminophen OD after several hours?
possibly vomiting but may have no symptoms at all
What are signs and symptoms of an acetaminophen OD after 24-72 hours?
Nausea, vomiting, abdominal pain/ cramps, abnormal liver function
What are the signs and symptoms of an acetaminophen OD after 3-4 days?
lots of vomiting, jaundice, bleeding in GI or GU, possible kidney failure, pancreas
may be inflammed
What are signs and symptoms of an acetaminophen OD in its final stage?
Abdominal swelling, abdominal pain, hepatic necrosis
What are treatments and their timeline to treat an acetaminophen OD?
Activated charcoal within the first 4 hours, Mucomyst (Acetylcysteine) within 24
hours, liver/kidney transplant
