CRNA - Medication/ Interview Questions
Study online at https://quizlet.com/_dxib5e
1. Phenylephrine (Neo-Synephrine): An alpha-1 adrenergic receptor agonist. In-
teracts with the receptors on the vascular smooth muscle cells, resulting in vaso-
constriction.
Increased SBP + DBP, while also increasing vagal activity causing rebound brady-
cardia.
Terminal Half-Life: 2.5 hours
No longer indicated in sepsis or severe septic shock
2. What is the antidote for phenylephrine/norepinephrine?: Phentolamine (Re-
gitine)
Hypodermic needle 5-10 mg to site that has been infiltrated.
3. Norepinephrine: Alpha-adrenergic action that functions as a peripheral vaso-
constrictor and inotropic stimulator of the heart and dilator of coronary arteries
(Beta-adrenergic action).
Dilates the coronary arteries more than twice as much as epinephrine can. It is
rapidly inactivated in the body by various enzymes and excreted in changed form in
the urine.
Used as front line in septic shock or sepsis after fluids.
4. Vasopressin: The vasoconstrictor effects of vasopressin are mediated by vas-
cular V1 receptors while the anti-diuretic effects are medicated by vascular or V2
receptors.
Tends to decrease heart rate and can actually lower cardiac output.
In patients with vasodilatory shock, vasopressin increased SVR and MAP while
reducing the dose requirements of other vasopressors such as:
.
In patients with DI, vasopressin inhibits water diuresis via renal V2 receptors.
Metabolized by the liver and kidney.
5. Propofol (Diprivan): IV general anesthetic
Can be used in conscious sedation or prolonged sedation.
Positively modulates the inhibitory function of GABA - A receptors causing global
1/5
, CRNA - Medication/ Interview Questions
Study online at https://quizlet.com/_dxib5e
CNS depression.
Induces anesthesia smoothly within 40 seconds.
Prolonged sedation cause lead to prolonged times waking up d/t drug accumulation
- however, sleep-wake trial will allow easier weaning in the future.
Terminal Half-Life 4 - 7 hours.
Metabolized in the liver.
Contradictions: Eggs and Soybean Oil allergies
6. Dobutamine (Dobutrex): A synthetic catecholamine chemically related to
dopamine, it is a direct-acting inotropic agent whose primary activity results from
stimulation of the beta-receptors. Induces short-term increase in cardiac output by
improving stroke volume w/ minimum increased in rate and BP, minimum rhythm
disturbances , and some decrease in systemic vascular resistance.
Half-life: 2 minutes
Metabolized in liver
7. Dopamine: Dopamine is a naturally occurring catecholamine that possesses
alpha , beta, and dopaminergic receptor-stimulating actions.
Dopamine effects are dose dependent.
Low doses vasoDILATION in the renal causing an increase in glomerular filtration
rate, blood flow, sodium excretion, and urine flow.
High doses alpha-adrenoreceptors are stimulated, resulting in vasoCONTRICTION
and in increase in blood pressure.
Doses over 20mcg/kg/min can cause decreased circulation in the limbs.
8. Milrinone (Primacor): Cardiac Inotropic Agent
Reduces afterload and preload by directly relaxing the effect on vascular smooth
muscle. Produces a slight enhancement in AV node conduction. Cardiac output is
improved with significant increases in HR or myocardial oxygen consumption or
changes in arteriovenous oxygen difference.
2/5
Study online at https://quizlet.com/_dxib5e
1. Phenylephrine (Neo-Synephrine): An alpha-1 adrenergic receptor agonist. In-
teracts with the receptors on the vascular smooth muscle cells, resulting in vaso-
constriction.
Increased SBP + DBP, while also increasing vagal activity causing rebound brady-
cardia.
Terminal Half-Life: 2.5 hours
No longer indicated in sepsis or severe septic shock
2. What is the antidote for phenylephrine/norepinephrine?: Phentolamine (Re-
gitine)
Hypodermic needle 5-10 mg to site that has been infiltrated.
3. Norepinephrine: Alpha-adrenergic action that functions as a peripheral vaso-
constrictor and inotropic stimulator of the heart and dilator of coronary arteries
(Beta-adrenergic action).
Dilates the coronary arteries more than twice as much as epinephrine can. It is
rapidly inactivated in the body by various enzymes and excreted in changed form in
the urine.
Used as front line in septic shock or sepsis after fluids.
4. Vasopressin: The vasoconstrictor effects of vasopressin are mediated by vas-
cular V1 receptors while the anti-diuretic effects are medicated by vascular or V2
receptors.
Tends to decrease heart rate and can actually lower cardiac output.
In patients with vasodilatory shock, vasopressin increased SVR and MAP while
reducing the dose requirements of other vasopressors such as:
.
In patients with DI, vasopressin inhibits water diuresis via renal V2 receptors.
Metabolized by the liver and kidney.
5. Propofol (Diprivan): IV general anesthetic
Can be used in conscious sedation or prolonged sedation.
Positively modulates the inhibitory function of GABA - A receptors causing global
1/5
, CRNA - Medication/ Interview Questions
Study online at https://quizlet.com/_dxib5e
CNS depression.
Induces anesthesia smoothly within 40 seconds.
Prolonged sedation cause lead to prolonged times waking up d/t drug accumulation
- however, sleep-wake trial will allow easier weaning in the future.
Terminal Half-Life 4 - 7 hours.
Metabolized in the liver.
Contradictions: Eggs and Soybean Oil allergies
6. Dobutamine (Dobutrex): A synthetic catecholamine chemically related to
dopamine, it is a direct-acting inotropic agent whose primary activity results from
stimulation of the beta-receptors. Induces short-term increase in cardiac output by
improving stroke volume w/ minimum increased in rate and BP, minimum rhythm
disturbances , and some decrease in systemic vascular resistance.
Half-life: 2 minutes
Metabolized in liver
7. Dopamine: Dopamine is a naturally occurring catecholamine that possesses
alpha , beta, and dopaminergic receptor-stimulating actions.
Dopamine effects are dose dependent.
Low doses vasoDILATION in the renal causing an increase in glomerular filtration
rate, blood flow, sodium excretion, and urine flow.
High doses alpha-adrenoreceptors are stimulated, resulting in vasoCONTRICTION
and in increase in blood pressure.
Doses over 20mcg/kg/min can cause decreased circulation in the limbs.
8. Milrinone (Primacor): Cardiac Inotropic Agent
Reduces afterload and preload by directly relaxing the effect on vascular smooth
muscle. Produces a slight enhancement in AV node conduction. Cardiac output is
improved with significant increases in HR or myocardial oxygen consumption or
changes in arteriovenous oxygen difference.
2/5
