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HESI Comprehensive Exit Exam 1 – United States Nursing Schools 2025 | Complete Practice Questions with Verified Answers & Rationales

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The HESI Comprehensive Exit Exam 1 (2025) is designed for nursing students in the United States preparing for their final exit exams. This updated resource includes complete practice questions with verified answers and detailed rationales, helping students master critical nursing concepts and clinical decision-making skills. Tailored to reflect the most current exam format, this guide provides accurate and reliable content to build confidence and ensure exam readiness. Ideal for RN students across U.S. nursing schools, this HESI practice exam offers a trusted way to prepare, save study time, and achieve success in the 2025 HESI Comprehensive Exit Exam.

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HESI Comprehensive Exit Exam 1 /United States
Nursing Schools 2025 /Complete Practice
Questions with Verified Answers and Rationales
Description:
This document contains 80 comprehensive, exam-style practice
questions designed for students preparing for the HESI
Comprehensive Exit Exam 1. Each question includes the correct
verified answer and a detailed rationale, covering essential
nursing topics such as pharmacology, maternal and newborn care,
medical-surgical nursing, pediatrics, psychiatric nursing, and
critical care. The content is suitable for review, practice, and test
preparation purposes and reflects current U.S. nursing standards
and HESI-style question formats.

Questions and Answers with Rationales:

1. The nurse is preparing to administer a high volume saline
enema to a client. Which information is most important for the
nurse to obtain prior to administering the enema?

a. History of inflammatory bowel disorders.

b. Reason for administering the enema.

c. Feelings about having an enema.

d. Allergies to medications.-Answer: A

,(Enemas should be avoided or administered with extreme caution
to clients with inflammatory bowel disorders, so obtaining this
historical information has the highest priority. Reason for the
enema and feelings about it also provide valuable informa- tion,
but are not of the same priority as history of IBS. Allergies are not
necessary prior to enema administration.)

2. The nurse is teaching an adolescent girl with scoliosis about
a Milwaukee brace which her healthcare provider has prescribed.
Which instruction would be accurate?

a. Remove the brace one hour each day for bathing only.

b. Remove the brace twice daily for back range of motion
exercises.

c. Wear the brace against the bare skin.

d. Wear the brace in order to cure the spinal curvature.-
Answer: A

(The brace should be worn 23 hours a day and removed a total of
one hour a day for hygiene. Continuation of present activities will
promote a positive self concept. There really is no such thing as
back range of motion exercises. A T-shirt should be worn next to
the body and the brace put on over the T-shirt. The brace should
not be worn against bare skin. The brace will not cure the spinal
curvature, but only slow the progression of the scoliosis.)

,3. The clinic nurse identifies an elevation in the results of the
triple marker screening test for a client who is in the first
trimester of pregnancy. Which action should the nurse prepare
the client for?

a. Repeating the triple marker test.

b. Preparing for other diagnostic testing.

c. Counseling about possible fetal defects.

d. Securing permission for pregnancy termination.-Answer: B

(The triple marker screen measures maternal serum levels for
alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG),
and estriol, which screens for indi- cations of possible fetal
defects. An elevated result may be a false indicator, so other tests
are indicated. Repeating the triple marker screening is not
necessary or helpful. Elevated results warrant further testing with
ultrasound or amniocentesis before initiating counseling for birth
defects or discussing termination of pregnancy.)

4. The nurse is caring for critically ill clients. Which client
should be moni- tored for the development of neurogenic shock?

a. Heart failure.

b. Gastrointestinal hemorrhage.

c. Spinal cord injury.

d. Diabetes insipidus.-Answer: C

, (Spinal cord injuries place the client at high risk for the
development of neurogenic distributive shock. The development
to watch for in clients with heart failure is cardiogenic shock, in GI
bleeding is hemorrhagic shock, and in diabetes insipidus is
hypovolemic shock.)

5. Following major abdominal surgery, a male client's arterial
blood gas analysis reveals Pa0 2 95 mmHg and PaC0 2 50 mmHg.
He is receiving oxygen by nasal cannula at 4 liters/minute and is
reluctant to move in bed or deep breathe. Based on this
information, what action should the nurse implement at this
time?

a. Increase the oxygen flow to 6 liters/minute.

b. Encourage the use of an incentive spirometer.

c. Notify the healthcare provider of the crisis blood gas values.

d. Encourage the client to breathe slower.-Answer: B

(The blood gas reveals adequate oxygenation (Pa02 95) and
hypoventilation (PaC02

> 45). The client needs to be encouraged in activities that increase
the depth of breathing (e. g., use of the incentive spirometer).
Increasing oxygen rate will only increase an already adequate
Pa02. These are not crisis blood gas findings so no need to call
healthcare provider. Asking client to breathe slower will only
worsen the hypoventilation.)

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