,TESTBANK for Pharmacology in Rehabilitation
Edition 5th Edition Charles D. Ciccone
Notes
1- The file is chapter after chapter.
2- We have shown you few pages sample.
3- The file contains all Appendix and Excel sheet
if it exists.
4- We have all what you need, we make update
at every time. There are many new editions
waiting you.
5- If you think you purchased the wrong file You
can contact us at every time, we can replace it
with true one.
Our email:
,Chapter 01
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. The use of specific drugs to prevent, treat, or diagnose disease is known as
a. toxicology
b. pharmacokinetics
c. pharmacotherapeutics
d. toxicokinetics
e. dynamic equilibrium
____ 2. The study of how the body deals with a drug in terms of the way the drug is absorbed, distributed, and
eliminated is known as
a. toxicology
b. pharmacodynamics
c. pharmacy
d. pharmacokinetics
e. biodynamics
____ 3. Toxicology is
a. the study of the harmful effects of chemicals
b. the study of a drug's beneficial effects
c. the analysis of drug absorption, distribution, and metabolism
d. the preparation and dispensing of therapeutic medications
e. the analysis of a drug's molecular structure
____ 4. The generic name of a drug
a. is also known as the “official” or “nonproprietary” name
b. is often derived from the chemical name
c. tends to be somewhat shorter than the drug's chemical name
d. all of the above are true
____ 5. If there is no existing patent for a drug, or if the patent has expired, the same drug may be marketed by
separate drug companies under different
a. chemical names
b. generic names
c. trade names
d. nonproprietary names
e. organic names
____ 6. The generic form of a drug is considered to be as safe and effective as the original, brand-name product if the
generic form _________ as the brand-name drug.
a. has the same type and amount of the active ingredient(s)
b. uses the same administration route
c. has the same pharmacokinetic profile (drug absorption, plasma levels, and so forth)
d. produces the same therapeutic effects
e. all the above are true
Copyright © F.A. Davis 2022 1
,____ 7. During drug testing and approval, the drug is usually tested in a relatively small sample (200 to 300 people)
with a specific disease or pathologic condition during
a. preclinical trials
b. phase 1 clinical trials
c. phase 2 clinical trials
d. postmarketing surveillance
____ 8. Drugs that can be purchased directly by the consumer without a prescription are also known as
a. nonproprietary medications
b. Schedule I controlled substances
c. Schedule II controlled substances
d. Schedule III controlled substances
e. over-the-counter drugs
____ 9. The point at which there is no further increase in the response to a drug even if the dosage continues to be
increased is known as the
a. ceiling effect
b. maximal efficacy
c. potency
d. all of the above
e. A and B only
____ 10. When two drugs are compared, the drug that requires a lower dosage to produce the same effect as a higher
dose of the second drug is said to
a. be more potent
b. be less potent
c. have a great maximal efficacy
d. have a greater therapeutic index
e. be pharmacosuperior
____ 11. When evaluating drug safety, the dosage that causes 50 percent of subjects to exhibit a specific adverse effect
is known as the
a. median therapeutic dose
b. median toxic dose
c. therapeutic index
d. ceiling effect
e. threshold dose
____ 12. In general, the greater the value of the _______, the safer the drug is considered to be.
a. median effective dose
b. threshold dose
c. therapeutic index (TI)
d. ceiling effect
e. potency index
____ 13. Regarding drug development and approval, an “orphan drug” is a drug that is
a. prescribed for conditions other than those approved by the FDA
b. given special funding for development because it is used in a small patient population with
a relatively rare disease
c. available directly to consumers without a prescription
d. only available in countries outside the United States
Copyright © F.A. Davis 2022 2
,____ 14. Prescription use of a drug to treat conditions other than those that the drug was originally approved to treat
(off label prescribing)
a. is illegal and punishable by revoking a physician’s license
b. is legal only if the Center for Disease Control provides written permission to the physician
c. is legal only if the drug is not a controlled substance
d. is legal and quite common in the United States
e. is legal only after the patent for a drug has expired
Copyright © F.A. Davis 2022 3
,Chapter 01
Answer Section
MULTIPLE CHOICE
1. ANS: C PTS: 1
2. ANS: D PTS: 1
3. ANS: A PTS: 1
4. ANS: D PTS: 1
5. ANS: C PTS: 1
6. ANS: E PTS: 1
7. ANS: C PTS: 1
8. ANS: E PTS: 1
9. ANS: E PTS: 1
10. ANS: A PTS: 1
11. ANS: B PTS: 1
12. ANS: C PTS: 1
13. ANS: B PTS: 1
14. ANS: D PTS: 1
Copyright © F.A. Davis 2022 4
,Chapter 02
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. All of the following are parenteral routes of drug administration EXCEPT the ____ route.
a. oral
b. inhalation
c. injection
d. topical
e. transdermal
____ 2. The ______ effect occurs when drugs are transported initially to the liver where a significant amount of the
drug may be metabolized and destroyed before the drug reaches its primary site of action.
a. malabsorptive
b. first pass
c. Bohr
d. bioequivalence
e. pharmacodynamic
____ 3. Iontophoresis, phonophoresis, and medicated patches all use the _____ route to administer drugs.
a. oral
b. inhalation
c. injection
d. transdermal
e. rectal
____ 4. This first pass effect is of particular concern when drugs are administered
a. topically
b. by intravenous injection
c. by subcutaneous injection
d. by inhalation
e. orally
____ 5. The extent to which a drug reaches the systemic circulation is referred to as
a. bioequivalence
b. biotransformation
c. bioavailability
d. biodistribution
e. last pass metabolism
____ 6. When crossing cell membranes, drugs will diffuse more readily through the lipid layer if they are
a. non-lipid soluble
b. in a neutral, nonionized form
c. in a charged, ionized form
d. large proteins
____ 7. Osmosis refers to the special case of diffusion where the diffusing substance is
a. a lipid soluble drug
b. a nonlipid soluble drug
c. a protein
Copyright © 2022 F.A. Davis 1
, d. a carbohydrate
e. water
____ 8. Carrier specificity, expenditure of energy, and ability to transport substances against a concentration gradient
are all characteristics of
a. simple, passive diffusion
b. facilitated diffusion
c. active transport
d. endocytosis
e. exocytosis
____ 9. A drug that has a volume of distribution of approximately 42 L will typically be
a. bound extensively to plasma proteins
b. retained in the bloodstream
c. concentrated in the tissues
d. stored in the liver and kidneys
e. distributed uniformly throughout all of the body fluids
____ 10. The primary site for drug storage in the body is
a. muscle
b. bone
c. skin
d. adipose tissue
e. the brain
____ 11. Drug developers are exploring nanotechnology (i.e., the use of very small particles with specific physical
properties) as a way to
a. target and deliver drugs to specific tissues within the body
b. facilitate drug absorption from the GI tract
c. enable drugs to cross the blood brain barrier more easily
d. all the above
e. none of the above
Copyright © 2022 F.A. Davis 2
,Chapter 02
Answer Section
MULTIPLE CHOICE
1. ANS: A PTS: 1
2. ANS: B PTS: 1
3. ANS: D PTS: 1
4. ANS: E PTS: 1
5. ANS: C PTS: 1
6. ANS: B PTS: 1
7. ANS: E PTS: 1
8. ANS: C PTS: 1
9. ANS: E PTS: 1
10. ANS: D PTS: 1
11. ANS: D PTS:1
Copyright © 2022 F.A. Davis 3
, Chapter 03
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Drug metabolism that occurs when a drug is changed chemically following administration is also known as
a. biotransformation
b. excretion
c. retoxification
d. degradation
e. allosterification
____ 2. Biotransformation usually results in an altered version of the original compound known as
a. bile
b. a metabolite
c. an antidrug
d. albumin
e. a steroid
____ 3. Drug oxidation occurs when ______ the original compound.
a. oxygen is added to
b. hydrogen is removed from
c. an endogenous substance such as acetyl coenzyme is coupled to
d. all of the above are true
e. only A and B are true
____ 4. The process of breaking the original drug compound into separate parts is known as
a. oxidation
b. reduction
c. conjugation
d. hydrolysis
e. biodestruction
____ 5. The primary location for drug metabolism (biotransformation) is the
a. liver
b. kidneys
c. lungs
d. skeletal muscle
e. adipose tissue
____ 6. Prolonged administration of therapeutic drugs and other substances (alcohol, nicotine) may enhance the liver's
ability to metabolize certain drugs, thus decreasing their therapeutic effect. This process is known as _______.
a. glomerulonephritis
b. biliary cirrhosis
c. decreased hepatic blood flow
d. enzyme induction
____ 7. Drugs and their metabolites are excreted from the body primarily by
a. the liver
b. the kidneys
c. the lungs
Copyright © 2022 F.A. Davis 1
Edition 5th Edition Charles D. Ciccone
Notes
1- The file is chapter after chapter.
2- We have shown you few pages sample.
3- The file contains all Appendix and Excel sheet
if it exists.
4- We have all what you need, we make update
at every time. There are many new editions
waiting you.
5- If you think you purchased the wrong file You
can contact us at every time, we can replace it
with true one.
Our email:
,Chapter 01
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. The use of specific drugs to prevent, treat, or diagnose disease is known as
a. toxicology
b. pharmacokinetics
c. pharmacotherapeutics
d. toxicokinetics
e. dynamic equilibrium
____ 2. The study of how the body deals with a drug in terms of the way the drug is absorbed, distributed, and
eliminated is known as
a. toxicology
b. pharmacodynamics
c. pharmacy
d. pharmacokinetics
e. biodynamics
____ 3. Toxicology is
a. the study of the harmful effects of chemicals
b. the study of a drug's beneficial effects
c. the analysis of drug absorption, distribution, and metabolism
d. the preparation and dispensing of therapeutic medications
e. the analysis of a drug's molecular structure
____ 4. The generic name of a drug
a. is also known as the “official” or “nonproprietary” name
b. is often derived from the chemical name
c. tends to be somewhat shorter than the drug's chemical name
d. all of the above are true
____ 5. If there is no existing patent for a drug, or if the patent has expired, the same drug may be marketed by
separate drug companies under different
a. chemical names
b. generic names
c. trade names
d. nonproprietary names
e. organic names
____ 6. The generic form of a drug is considered to be as safe and effective as the original, brand-name product if the
generic form _________ as the brand-name drug.
a. has the same type and amount of the active ingredient(s)
b. uses the same administration route
c. has the same pharmacokinetic profile (drug absorption, plasma levels, and so forth)
d. produces the same therapeutic effects
e. all the above are true
Copyright © F.A. Davis 2022 1
,____ 7. During drug testing and approval, the drug is usually tested in a relatively small sample (200 to 300 people)
with a specific disease or pathologic condition during
a. preclinical trials
b. phase 1 clinical trials
c. phase 2 clinical trials
d. postmarketing surveillance
____ 8. Drugs that can be purchased directly by the consumer without a prescription are also known as
a. nonproprietary medications
b. Schedule I controlled substances
c. Schedule II controlled substances
d. Schedule III controlled substances
e. over-the-counter drugs
____ 9. The point at which there is no further increase in the response to a drug even if the dosage continues to be
increased is known as the
a. ceiling effect
b. maximal efficacy
c. potency
d. all of the above
e. A and B only
____ 10. When two drugs are compared, the drug that requires a lower dosage to produce the same effect as a higher
dose of the second drug is said to
a. be more potent
b. be less potent
c. have a great maximal efficacy
d. have a greater therapeutic index
e. be pharmacosuperior
____ 11. When evaluating drug safety, the dosage that causes 50 percent of subjects to exhibit a specific adverse effect
is known as the
a. median therapeutic dose
b. median toxic dose
c. therapeutic index
d. ceiling effect
e. threshold dose
____ 12. In general, the greater the value of the _______, the safer the drug is considered to be.
a. median effective dose
b. threshold dose
c. therapeutic index (TI)
d. ceiling effect
e. potency index
____ 13. Regarding drug development and approval, an “orphan drug” is a drug that is
a. prescribed for conditions other than those approved by the FDA
b. given special funding for development because it is used in a small patient population with
a relatively rare disease
c. available directly to consumers without a prescription
d. only available in countries outside the United States
Copyright © F.A. Davis 2022 2
,____ 14. Prescription use of a drug to treat conditions other than those that the drug was originally approved to treat
(off label prescribing)
a. is illegal and punishable by revoking a physician’s license
b. is legal only if the Center for Disease Control provides written permission to the physician
c. is legal only if the drug is not a controlled substance
d. is legal and quite common in the United States
e. is legal only after the patent for a drug has expired
Copyright © F.A. Davis 2022 3
,Chapter 01
Answer Section
MULTIPLE CHOICE
1. ANS: C PTS: 1
2. ANS: D PTS: 1
3. ANS: A PTS: 1
4. ANS: D PTS: 1
5. ANS: C PTS: 1
6. ANS: E PTS: 1
7. ANS: C PTS: 1
8. ANS: E PTS: 1
9. ANS: E PTS: 1
10. ANS: A PTS: 1
11. ANS: B PTS: 1
12. ANS: C PTS: 1
13. ANS: B PTS: 1
14. ANS: D PTS: 1
Copyright © F.A. Davis 2022 4
,Chapter 02
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. All of the following are parenteral routes of drug administration EXCEPT the ____ route.
a. oral
b. inhalation
c. injection
d. topical
e. transdermal
____ 2. The ______ effect occurs when drugs are transported initially to the liver where a significant amount of the
drug may be metabolized and destroyed before the drug reaches its primary site of action.
a. malabsorptive
b. first pass
c. Bohr
d. bioequivalence
e. pharmacodynamic
____ 3. Iontophoresis, phonophoresis, and medicated patches all use the _____ route to administer drugs.
a. oral
b. inhalation
c. injection
d. transdermal
e. rectal
____ 4. This first pass effect is of particular concern when drugs are administered
a. topically
b. by intravenous injection
c. by subcutaneous injection
d. by inhalation
e. orally
____ 5. The extent to which a drug reaches the systemic circulation is referred to as
a. bioequivalence
b. biotransformation
c. bioavailability
d. biodistribution
e. last pass metabolism
____ 6. When crossing cell membranes, drugs will diffuse more readily through the lipid layer if they are
a. non-lipid soluble
b. in a neutral, nonionized form
c. in a charged, ionized form
d. large proteins
____ 7. Osmosis refers to the special case of diffusion where the diffusing substance is
a. a lipid soluble drug
b. a nonlipid soluble drug
c. a protein
Copyright © 2022 F.A. Davis 1
, d. a carbohydrate
e. water
____ 8. Carrier specificity, expenditure of energy, and ability to transport substances against a concentration gradient
are all characteristics of
a. simple, passive diffusion
b. facilitated diffusion
c. active transport
d. endocytosis
e. exocytosis
____ 9. A drug that has a volume of distribution of approximately 42 L will typically be
a. bound extensively to plasma proteins
b. retained in the bloodstream
c. concentrated in the tissues
d. stored in the liver and kidneys
e. distributed uniformly throughout all of the body fluids
____ 10. The primary site for drug storage in the body is
a. muscle
b. bone
c. skin
d. adipose tissue
e. the brain
____ 11. Drug developers are exploring nanotechnology (i.e., the use of very small particles with specific physical
properties) as a way to
a. target and deliver drugs to specific tissues within the body
b. facilitate drug absorption from the GI tract
c. enable drugs to cross the blood brain barrier more easily
d. all the above
e. none of the above
Copyright © 2022 F.A. Davis 2
,Chapter 02
Answer Section
MULTIPLE CHOICE
1. ANS: A PTS: 1
2. ANS: B PTS: 1
3. ANS: D PTS: 1
4. ANS: E PTS: 1
5. ANS: C PTS: 1
6. ANS: B PTS: 1
7. ANS: E PTS: 1
8. ANS: C PTS: 1
9. ANS: E PTS: 1
10. ANS: D PTS: 1
11. ANS: D PTS:1
Copyright © 2022 F.A. Davis 3
, Chapter 03
Multiple Choice
Identify the choice that best completes the statement or answers the question.
____ 1. Drug metabolism that occurs when a drug is changed chemically following administration is also known as
a. biotransformation
b. excretion
c. retoxification
d. degradation
e. allosterification
____ 2. Biotransformation usually results in an altered version of the original compound known as
a. bile
b. a metabolite
c. an antidrug
d. albumin
e. a steroid
____ 3. Drug oxidation occurs when ______ the original compound.
a. oxygen is added to
b. hydrogen is removed from
c. an endogenous substance such as acetyl coenzyme is coupled to
d. all of the above are true
e. only A and B are true
____ 4. The process of breaking the original drug compound into separate parts is known as
a. oxidation
b. reduction
c. conjugation
d. hydrolysis
e. biodestruction
____ 5. The primary location for drug metabolism (biotransformation) is the
a. liver
b. kidneys
c. lungs
d. skeletal muscle
e. adipose tissue
____ 6. Prolonged administration of therapeutic drugs and other substances (alcohol, nicotine) may enhance the liver's
ability to metabolize certain drugs, thus decreasing their therapeutic effect. This process is known as _______.
a. glomerulonephritis
b. biliary cirrhosis
c. decreased hepatic blood flow
d. enzyme induction
____ 7. Drugs and their metabolites are excreted from the body primarily by
a. the liver
b. the kidneys
c. the lungs
Copyright © 2022 F.A. Davis 1
