ONS Chemotherapy Immunotherapy
Certificate Exam With 100% Correct
Answers
3 major phases of cell division: - Correct Answer-Interphase
Mitotic phase
Cytokinesis
3 steps of interphase: - Correct Answer-First growth phase (G1)
Synthesis phase (S phase)
Second growth phase (G2)
4 phases of mitosis: - Correct Answer-Prophase
Metaphase
Anaphase
Telophase
Innate immunity: - Correct Answer-Non-specific response, either:
1. Barrier (skin, mucous membranes, flora of skin/gut)
2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages)
Adaptive immunity: - Correct Answer-Follows innate immunity if unsuccessful. Memory
immunity, including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon T cells)
3. Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses)
Define mutations - Correct Answer-Variations in the nucleotide sequence of a gene
3 main goals of treatment: - Correct Answer-Cure
Control
Palliation
Define neoadjuvant therapy - Correct Answer-Treatment is given prior to surgery to
shrink the tumor
Define adjuvant therapy - Correct Answer-Additional cancer treatment given after the
primary treatment to lower the risk that the cancer reoccur
Define conditioning/preparative therapy - Correct Answer-Treatments used to prepare a
patient for stem cell transplantation
, 2 types of conditioning therapies: - Correct Answer-Myeloablative
Nonmyeloablative
Define dose density - Correct Answer-Drug dose per unit of time
Define dose intensity - Correct Answer-Amount of drug delivered over time
How is relative dose intensity (RDI) calculated? - Correct Answer-By comparing the
dose that the patient ACTUALLY received to the planned dose of the standard regimen
How do alkylating agents work? - Correct Answer-By causing a break in the DNA helix
strand, interfering with DNA replication and causing cell death
3 subcategories of alkylating agents: - Correct Answer-1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: - Correct Answer-Nitrogen mustards
Common alkylating agents: - Correct Answer-Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - Correct Answer-Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - Correct Answer-Able to cross the blood-
brain barrier; can be effective in treating some brain tumors
Common nitrosoureas agents: - Correct Answer-Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - Correct Answer-Carboplatin
These agents are typically categorized as highly emetogenic: - Correct Answer-1.
Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - Correct Answer-BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - Correct Answer-Bladder protectant with
administration of cyclophosphamide or ifosfamide
Certificate Exam With 100% Correct
Answers
3 major phases of cell division: - Correct Answer-Interphase
Mitotic phase
Cytokinesis
3 steps of interphase: - Correct Answer-First growth phase (G1)
Synthesis phase (S phase)
Second growth phase (G2)
4 phases of mitosis: - Correct Answer-Prophase
Metaphase
Anaphase
Telophase
Innate immunity: - Correct Answer-Non-specific response, either:
1. Barrier (skin, mucous membranes, flora of skin/gut)
2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages)
Adaptive immunity: - Correct Answer-Follows innate immunity if unsuccessful. Memory
immunity, including:
1. Humoral immunity (production of antibodies or immunoglobulins)
2. Cell mediated immunity (dependent upon T cells)
3. Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses)
Define mutations - Correct Answer-Variations in the nucleotide sequence of a gene
3 main goals of treatment: - Correct Answer-Cure
Control
Palliation
Define neoadjuvant therapy - Correct Answer-Treatment is given prior to surgery to
shrink the tumor
Define adjuvant therapy - Correct Answer-Additional cancer treatment given after the
primary treatment to lower the risk that the cancer reoccur
Define conditioning/preparative therapy - Correct Answer-Treatments used to prepare a
patient for stem cell transplantation
, 2 types of conditioning therapies: - Correct Answer-Myeloablative
Nonmyeloablative
Define dose density - Correct Answer-Drug dose per unit of time
Define dose intensity - Correct Answer-Amount of drug delivered over time
How is relative dose intensity (RDI) calculated? - Correct Answer-By comparing the
dose that the patient ACTUALLY received to the planned dose of the standard regimen
How do alkylating agents work? - Correct Answer-By causing a break in the DNA helix
strand, interfering with DNA replication and causing cell death
3 subcategories of alkylating agents: - Correct Answer-1. Nitrogen mustards
2. Platinum-based agents (do not possess an alkyl group but still termed alkylating
agents as they work similarly)
3. Nitrosoureas
Most common subcategory of alkylating agents: - Correct Answer-Nitrogen mustards
Common alkylating agents: - Correct Answer-Cyclophosphamide (Cytoxan)
Ifosfamide (Ifex)
Bendamustine (Treanda)
Common platinum-based agents: - Correct Answer-Cisplatin (Platinol)
Carboplatin (Paraplatin)
What is unique about nitrosoureas agents? - Correct Answer-Able to cross the blood-
brain barrier; can be effective in treating some brain tumors
Common nitrosoureas agents: - Correct Answer-Carmustine (BiCNU)
Lomustine (CeeNu)
Streptozocin (Zanosar)
Hypersensitivity can occur with late doses of: - Correct Answer-Carboplatin
These agents are typically categorized as highly emetogenic: - Correct Answer-1.
Alkylating agents
2. Nitrosoureas
Pre-administration labs for alkylating agents and nitrosoureas: - Correct Answer-BUN
Creatinine
CBC w/ diff
What is the medication Mesna used for? - Correct Answer-Bladder protectant with
administration of cyclophosphamide or ifosfamide
