8/28/25, 10:58 PM HESI NCLEX RN: Pharmacology
2025-2026 NGN\ NCLEX HESI RN PHARMACOLOGY REAL EXAMS
(4 VERSIONS) WITH ALL QUESTIONS AND CORRECT ANSWERS
WITH RATIONALES (100% CORRECT ANSWERS) RN HESI
PHARMACOLOGY WITH NGN LATEST 4 VERSIONS 2025/2026
ALREADY GRADED A+(NEWEST!!)
A client who is HIV- C.
positive is receiving Return to the clinic every 2 weeks for blood counts.
combination therapy with Rationale:Bone marrow depression with
the antiviral medication granulocytopenia is a severe but common adverse
zidovudine. Which effect of zidovudine. Careful monitoring of CBCs is
instruction should the indicated. Options A and B are not correct instructions
nurse include in this related to use of this medication. Option D is an
client's teaching plan? expected side effect. The client should be instructed
A. to avoid driving until this reaction improves.
Take the drug as
prescribed to cure HIV
infections.
B.
Use the drug to
reduce the risk of
transmitting HIV to
sexual contacts. C.
Return to the clinic every 2
weeks for blood counts.
D.
Report to the health
care provider
immediately if dizziness is
experienced.
/ 1/51
,8/28/25, 10:58 PM HESI NCLEX RN: Pharmacology
Which instructions should A,E,F
the nurse provide to an Rationale:Isotretinoin has been found to cause
adolescent female client who pregnancy category D drug-related birth defects,
is initiating treatment with premature births, and fetal death (A), which
isotretinoin for acne necessitates the use of effective birth control methods
vulgaris? (Select all that before, during, and after therapy (F). Isotretinoin is
apply.) associated with sadness (E), depression, suicidal
A. ideations, and other serious mental health problems. An
“Notify the health care initial exacerbation of acne (B) is common when
provider immediately if you starting drug therapy. Isotretinoin is a retinoid related
think you are pregnant.” B. to vitamin A, and taking additional multivitamin
“If your acne gets worse, supplements (C) can predispose the client to vitamin A
stop the medication and toxicity. The client should stop taking isotretinoin at
call the health care least 6 months before cosmetic procedures, such as
provider.” dermabrasion (D), because the drug can increase the
C.
chances of scarring.
“Take a daily multiple
vitamin to prevent
deficiencies and promote
dermal healing.” D.
“Dermabrasion for deep
acne scars should be
postponed for 1 month after
therapy is stopped.”
E.
“If you begin crying more
than usual and feel sad, stop
the drug and call the health
care provider.”
F.
“Before, during, and after
therapy, two effective
forms of birth control must
be used at the same
time.”
/ 2/51
,8/28/25, 10:58 PM HESI NCLEX RN: Pharmacology
The nurse is preparing a A.
child for transport to the Decrease the oral secretions.
operating room for an
emergency
appendectomy. The
anesthesiologist prescribes
atropine sulfate, IM STAT.
What is the primary
purpose for administering
this drug to the child at
this time?
A.
Decrease the oral
secretions. B.
Reduce the child's
anxiety. C.
Potentiate the
opioid effects. D.
Prevent possible peritonitis.
/ 3/51
, 8/28/25, 10:58 PM HESI NCLEX RN: Pharmacology
A client who is D.
experiencing an acute Report any vomiting to the clinic.
attack of gouty arthritis is Rationale:The client should be instructed to report
prescribed colchicine USP, signs of colchicine toxicity, such as nausea, diarrhea,
1 mg PO daily. Which vomiting, and/or abdominal pain, to the health care
information is most provider. Food inhibits the absorption of colchicine when
important for the nurse to ingested concurrently. Limited fluid intake decreases
provide the client? the excretion of the uric acid crystals, which contributes
to painful attacks. Typically, a client should remain on
A. a daily dose of colchicine to decrease the number and
Take the medication severity of acute attacks, so stopping the medication
with meals. B. after the pain resolves is not indicated.
Limit fluid intake until the
attack subsides. C.
Stop the medication when
the pain resolves.
D.
Report any vomiting to the
clinic.
A client is being D.
discharged with a Drink at least eight glasses of fluid a day.
prescription for
sulfasalazine to treat Adequate hydration is important for all sulfa drugs
ulcerative colitis. Which because they can crystallize in the urine. If possible,
instruction should the the drug should be taken after eating to provide
nurse provide to this longer intestinal transit time. Option A is important for
client prior to discharge? other medications, such as phenytoin, because of the
incidence of gingival hyperplasia, and option C is
A. important for steroid administration, but option D is
Maintain good oral most important to stress with this client.
hygiene. B.
Take the medication 30
minutes before a meal.
C.
Discontinue use of the
drug gradually. D.
Drink at least eight glasses of
fluid a day.
/ 4/51
2025-2026 NGN\ NCLEX HESI RN PHARMACOLOGY REAL EXAMS
(4 VERSIONS) WITH ALL QUESTIONS AND CORRECT ANSWERS
WITH RATIONALES (100% CORRECT ANSWERS) RN HESI
PHARMACOLOGY WITH NGN LATEST 4 VERSIONS 2025/2026
ALREADY GRADED A+(NEWEST!!)
A client who is HIV- C.
positive is receiving Return to the clinic every 2 weeks for blood counts.
combination therapy with Rationale:Bone marrow depression with
the antiviral medication granulocytopenia is a severe but common adverse
zidovudine. Which effect of zidovudine. Careful monitoring of CBCs is
instruction should the indicated. Options A and B are not correct instructions
nurse include in this related to use of this medication. Option D is an
client's teaching plan? expected side effect. The client should be instructed
A. to avoid driving until this reaction improves.
Take the drug as
prescribed to cure HIV
infections.
B.
Use the drug to
reduce the risk of
transmitting HIV to
sexual contacts. C.
Return to the clinic every 2
weeks for blood counts.
D.
Report to the health
care provider
immediately if dizziness is
experienced.
/ 1/51
,8/28/25, 10:58 PM HESI NCLEX RN: Pharmacology
Which instructions should A,E,F
the nurse provide to an Rationale:Isotretinoin has been found to cause
adolescent female client who pregnancy category D drug-related birth defects,
is initiating treatment with premature births, and fetal death (A), which
isotretinoin for acne necessitates the use of effective birth control methods
vulgaris? (Select all that before, during, and after therapy (F). Isotretinoin is
apply.) associated with sadness (E), depression, suicidal
A. ideations, and other serious mental health problems. An
“Notify the health care initial exacerbation of acne (B) is common when
provider immediately if you starting drug therapy. Isotretinoin is a retinoid related
think you are pregnant.” B. to vitamin A, and taking additional multivitamin
“If your acne gets worse, supplements (C) can predispose the client to vitamin A
stop the medication and toxicity. The client should stop taking isotretinoin at
call the health care least 6 months before cosmetic procedures, such as
provider.” dermabrasion (D), because the drug can increase the
C.
chances of scarring.
“Take a daily multiple
vitamin to prevent
deficiencies and promote
dermal healing.” D.
“Dermabrasion for deep
acne scars should be
postponed for 1 month after
therapy is stopped.”
E.
“If you begin crying more
than usual and feel sad, stop
the drug and call the health
care provider.”
F.
“Before, during, and after
therapy, two effective
forms of birth control must
be used at the same
time.”
/ 2/51
,8/28/25, 10:58 PM HESI NCLEX RN: Pharmacology
The nurse is preparing a A.
child for transport to the Decrease the oral secretions.
operating room for an
emergency
appendectomy. The
anesthesiologist prescribes
atropine sulfate, IM STAT.
What is the primary
purpose for administering
this drug to the child at
this time?
A.
Decrease the oral
secretions. B.
Reduce the child's
anxiety. C.
Potentiate the
opioid effects. D.
Prevent possible peritonitis.
/ 3/51
, 8/28/25, 10:58 PM HESI NCLEX RN: Pharmacology
A client who is D.
experiencing an acute Report any vomiting to the clinic.
attack of gouty arthritis is Rationale:The client should be instructed to report
prescribed colchicine USP, signs of colchicine toxicity, such as nausea, diarrhea,
1 mg PO daily. Which vomiting, and/or abdominal pain, to the health care
information is most provider. Food inhibits the absorption of colchicine when
important for the nurse to ingested concurrently. Limited fluid intake decreases
provide the client? the excretion of the uric acid crystals, which contributes
to painful attacks. Typically, a client should remain on
A. a daily dose of colchicine to decrease the number and
Take the medication severity of acute attacks, so stopping the medication
with meals. B. after the pain resolves is not indicated.
Limit fluid intake until the
attack subsides. C.
Stop the medication when
the pain resolves.
D.
Report any vomiting to the
clinic.
A client is being D.
discharged with a Drink at least eight glasses of fluid a day.
prescription for
sulfasalazine to treat Adequate hydration is important for all sulfa drugs
ulcerative colitis. Which because they can crystallize in the urine. If possible,
instruction should the the drug should be taken after eating to provide
nurse provide to this longer intestinal transit time. Option A is important for
client prior to discharge? other medications, such as phenytoin, because of the
incidence of gingival hyperplasia, and option C is
A. important for steroid administration, but option D is
Maintain good oral most important to stress with this client.
hygiene. B.
Take the medication 30
minutes before a meal.
C.
Discontinue use of the
drug gradually. D.
Drink at least eight glasses of
fluid a day.
/ 4/51
