ANCC IQ
Domain 1 - 5
Complete Coverage Actual Questions
Answers with Rationales
Why this resource is valuable:
✔ Complete Coverage – Includes all 5 ANCC IQ
domains in one guide.
✔ Verified Correct Answers – Ensures accuracy
and saves study time.
✔ Exam-Style Questions – Reflects the official
ANCC Informatics Nursing exam format.
✔ 100% Pass Guarantee – Designed for first-attempt success.
✔ Instant Digital Download – Access across devices for flexible
studying.
,Table of Contents
ANCC IQ domain 1 ............................................................... 2
ANCC IQ domain 2 ............................................................. 23
ANCC IQ domain 3 ............................................................. 51
ANCC IQ domain 4 ............................................................. 79
ANCC IQ domain 5 ............................................................. 97
ANCC IQ domain 1
While treating a 12-year-old boy for ADHD, the PMHNP observes
which of the following physical features that raise concerns for
genetic evaluation for Fragile X Syndrome?
-obesity, small stature, small hands and feet, hypotonia
-café au lait spots on face and arms, neurofibromas
-long head and ears, short stature, hyperextensible joints
-small stature, short palpebral fissure, inner epicanthal folds
-long head and ears, short stature, hyperextensible joints
Rationale: Etiological factors in mental retardation can be primarily
genetic, developmental, acquired, or in combination. Genetic causes
included chromosomal and inherited conditions. Many of these genetic
disorders have characteristic physical features that warrant genetic testing
for confirmatory diagnosis. Fragile X Syndrome occurs in about 1 of every
1,000 males and 1 of every 2,000 females. The typical phenotype includes
a large, long head and ears, short stature, hyperextensible joints, and
,postpubertal macroorchidism. The mentalretardation ranges from mild to
severe. There is high rate of comorbid ADHD, learning disorder, and
pervasive developmental disorders, such as autism. Café au lait spots and
neurofibromas are common in von Recklinghausen’s disease. Obesity,
small stature, small hands and feet, hypotonia, and hypogonadism are
characteristic of Prader-Willi Syndrome. Small head, short palpebral
fissure, and inner epicanthal folds are characteristic of fetal alcohol
syndrome.
Which of the following patients with generalized anxiety disorder is
most likely to be a CYP 2C19 poor metabolizer and have an
exaggerated response to diazepam (Valium) 5 mg TID with increased
sedation, central nervous system, and cognitive side effects?
-40-year-old Asian male
-30-year-old African American male
20-year-old African American male
50-year-old Caucasian male
-40-year-old Asian male
Rationale: The frequency of poor metabolizers of CYP 2C19 is low among
Caucasians (3%), intermediate among African Americans (18%), and
higher in Asian and Japanese populations (up to 20%).
Which serotonin receptor antagonism makes an antipsychotic
"atypical"?
-5HT2A
, -5HT1A
-5HT4A
-5HT3A
-5HT2A
Rationale: The mechanism of action that makes an antipsychotic
medication "atypical" is related to the 5HT2A receptor antagonism and D2
receptor antagonism.
-5HT1A
-5HT4A
-5HT3A
Which mood stabilizer is most associated with a potentially life-
threatening rash?
-lamotrigine (Lamictal)
Lamotrigine is associated with a rare, serious, and potentially life-
threatening rash (Steven Johnsons syndrome
Which of the following findings would raise concern in a pre-school
wellness exam for a 5-year-old girl?
height 43 inches, weight 55 lbs
Rationale: Body Mass Index (BMI) calculated for this height and weight is
21, which is greater than 95th percentile for her age, placing her in
overweight category. Calculation: Weight (lbs) /Stature (inches) / Stature
(inches) x 703 = BMI
BMI = 703 x weight (lbs) = 703 x 55
[Height (in)]2 432
Or Weight (kg)/ Stature (cm)/ Stature (cm) x 10,000 = BMI.
BMI = weight (kg)
Domain 1 - 5
Complete Coverage Actual Questions
Answers with Rationales
Why this resource is valuable:
✔ Complete Coverage – Includes all 5 ANCC IQ
domains in one guide.
✔ Verified Correct Answers – Ensures accuracy
and saves study time.
✔ Exam-Style Questions – Reflects the official
ANCC Informatics Nursing exam format.
✔ 100% Pass Guarantee – Designed for first-attempt success.
✔ Instant Digital Download – Access across devices for flexible
studying.
,Table of Contents
ANCC IQ domain 1 ............................................................... 2
ANCC IQ domain 2 ............................................................. 23
ANCC IQ domain 3 ............................................................. 51
ANCC IQ domain 4 ............................................................. 79
ANCC IQ domain 5 ............................................................. 97
ANCC IQ domain 1
While treating a 12-year-old boy for ADHD, the PMHNP observes
which of the following physical features that raise concerns for
genetic evaluation for Fragile X Syndrome?
-obesity, small stature, small hands and feet, hypotonia
-café au lait spots on face and arms, neurofibromas
-long head and ears, short stature, hyperextensible joints
-small stature, short palpebral fissure, inner epicanthal folds
-long head and ears, short stature, hyperextensible joints
Rationale: Etiological factors in mental retardation can be primarily
genetic, developmental, acquired, or in combination. Genetic causes
included chromosomal and inherited conditions. Many of these genetic
disorders have characteristic physical features that warrant genetic testing
for confirmatory diagnosis. Fragile X Syndrome occurs in about 1 of every
1,000 males and 1 of every 2,000 females. The typical phenotype includes
a large, long head and ears, short stature, hyperextensible joints, and
,postpubertal macroorchidism. The mentalretardation ranges from mild to
severe. There is high rate of comorbid ADHD, learning disorder, and
pervasive developmental disorders, such as autism. Café au lait spots and
neurofibromas are common in von Recklinghausen’s disease. Obesity,
small stature, small hands and feet, hypotonia, and hypogonadism are
characteristic of Prader-Willi Syndrome. Small head, short palpebral
fissure, and inner epicanthal folds are characteristic of fetal alcohol
syndrome.
Which of the following patients with generalized anxiety disorder is
most likely to be a CYP 2C19 poor metabolizer and have an
exaggerated response to diazepam (Valium) 5 mg TID with increased
sedation, central nervous system, and cognitive side effects?
-40-year-old Asian male
-30-year-old African American male
20-year-old African American male
50-year-old Caucasian male
-40-year-old Asian male
Rationale: The frequency of poor metabolizers of CYP 2C19 is low among
Caucasians (3%), intermediate among African Americans (18%), and
higher in Asian and Japanese populations (up to 20%).
Which serotonin receptor antagonism makes an antipsychotic
"atypical"?
-5HT2A
, -5HT1A
-5HT4A
-5HT3A
-5HT2A
Rationale: The mechanism of action that makes an antipsychotic
medication "atypical" is related to the 5HT2A receptor antagonism and D2
receptor antagonism.
-5HT1A
-5HT4A
-5HT3A
Which mood stabilizer is most associated with a potentially life-
threatening rash?
-lamotrigine (Lamictal)
Lamotrigine is associated with a rare, serious, and potentially life-
threatening rash (Steven Johnsons syndrome
Which of the following findings would raise concern in a pre-school
wellness exam for a 5-year-old girl?
height 43 inches, weight 55 lbs
Rationale: Body Mass Index (BMI) calculated for this height and weight is
21, which is greater than 95th percentile for her age, placing her in
overweight category. Calculation: Weight (lbs) /Stature (inches) / Stature
(inches) x 703 = BMI
BMI = 703 x weight (lbs) = 703 x 55
[Height (in)]2 432
Or Weight (kg)/ Stature (cm)/ Stature (cm) x 10,000 = BMI.
BMI = weight (kg)
