Nr565 Adv Pharm Week 7 Advanced
Pharmacology Fundamentals -
Chamberlain
· H2 receptor antagonists
o Examples
o Which is most likely to interact due to CYP450 enzyme system? -
✔✔✔ANSWER-Ex. Cimetidine, Famotidine, Nizatidine, Ranitidine
Interaction: Cimetidine
· Proton Pump Inhibitors
o Associated vitamin and/or mineral deficiencies
o Short term use increases risk of what?
§ Symptoms this may be occurring - ✔✔✔ANSWER--Decreased absorption of
calcium, magnesium, and vitamin B12 has also been associated with long-term PPI
, use; therefore, PPIs are contraindicated in individuals with hypocalcemia due to
complications of bone fractures.
-Risk of community-acquired pneumonia (CAP) has been observed with the short-
term use of PPI
S+S: cough, fever, shaking chills, and shortness of breath.
o How to treat moderate to severe GERD - ✔✔✔ANSWER-Long-term use of
PPIs
o What medication for GERD to avoid in older adults and why? -
✔✔✔ANSWER-PPIs are associated with an increased risk for fractures from
osteoporosis. PPIs can also cause medication interactions and vitamin or mineral
deficiencies. There should be a clear indication for prescribing these medications to
this older population.
o Treating GERD during pregnancy
§ Which cytoprotective agents would be used - ✔✔✔ANSWER-Sucralfate is
classified as a Pregnancy Category B agent and is safe to prescribe during
pregnancy.
Misoprostol is contraindicated as it can cause the death of the fetus
When to test for h. Pylori
How to treat h. Pylori - ✔✔✔ANSWER-Prior to starting H2RA and PPI
therapy
Tx: Amoxicillin, Pepto-Bismol, Clarithromycin, Metronidazole, Tetracycline,
Tinidazole
Pharmacology Fundamentals -
Chamberlain
· H2 receptor antagonists
o Examples
o Which is most likely to interact due to CYP450 enzyme system? -
✔✔✔ANSWER-Ex. Cimetidine, Famotidine, Nizatidine, Ranitidine
Interaction: Cimetidine
· Proton Pump Inhibitors
o Associated vitamin and/or mineral deficiencies
o Short term use increases risk of what?
§ Symptoms this may be occurring - ✔✔✔ANSWER--Decreased absorption of
calcium, magnesium, and vitamin B12 has also been associated with long-term PPI
, use; therefore, PPIs are contraindicated in individuals with hypocalcemia due to
complications of bone fractures.
-Risk of community-acquired pneumonia (CAP) has been observed with the short-
term use of PPI
S+S: cough, fever, shaking chills, and shortness of breath.
o How to treat moderate to severe GERD - ✔✔✔ANSWER-Long-term use of
PPIs
o What medication for GERD to avoid in older adults and why? -
✔✔✔ANSWER-PPIs are associated with an increased risk for fractures from
osteoporosis. PPIs can also cause medication interactions and vitamin or mineral
deficiencies. There should be a clear indication for prescribing these medications to
this older population.
o Treating GERD during pregnancy
§ Which cytoprotective agents would be used - ✔✔✔ANSWER-Sucralfate is
classified as a Pregnancy Category B agent and is safe to prescribe during
pregnancy.
Misoprostol is contraindicated as it can cause the death of the fetus
When to test for h. Pylori
How to treat h. Pylori - ✔✔✔ANSWER-Prior to starting H2RA and PPI
therapy
Tx: Amoxicillin, Pepto-Bismol, Clarithromycin, Metronidazole, Tetracycline,
Tinidazole
