PGX EXAM 3 (SOLVED) QUIZZES &
ANS!!
1 of
16
Definition
-CYP2C9 PM or IM: higher systemic conc skin reactions
-HLA-B positive: increased risk for stevens johnson sysndrome
Give this one a try later!
Fospheytoin Voriconazole
Carbamazepine Phenytoin
, Don't know?
2 of 16
Definition
-CYP2C19 active drug
-Recommendation: Choose an alternative agent that is not
dependent on CYP2C19 metabolism as primary therapy in
lieu of voriconazole. Such agents include isavuconazole,
liposomal
amphotericin B, and posaconazole. (poor metabolizer)
-concern: increase risk of
toxicity Includes pediatric
dosing
Non-linear kinetics:dosing changes not
recommended No FDA recommendation
PM means avoid this drug b/c toxicity
Give this one a try later!
Voriconazole Carbamazepine
Phenytoin Clopidogrel
Don't know?
ANS!!
1 of
16
Definition
-CYP2C9 PM or IM: higher systemic conc skin reactions
-HLA-B positive: increased risk for stevens johnson sysndrome
Give this one a try later!
Fospheytoin Voriconazole
Carbamazepine Phenytoin
, Don't know?
2 of 16
Definition
-CYP2C19 active drug
-Recommendation: Choose an alternative agent that is not
dependent on CYP2C19 metabolism as primary therapy in
lieu of voriconazole. Such agents include isavuconazole,
liposomal
amphotericin B, and posaconazole. (poor metabolizer)
-concern: increase risk of
toxicity Includes pediatric
dosing
Non-linear kinetics:dosing changes not
recommended No FDA recommendation
PM means avoid this drug b/c toxicity
Give this one a try later!
Voriconazole Carbamazepine
Phenytoin Clopidogrel
Don't know?
