1. T/F: Almost all cancer gene mutations are
inherited False
2. True or false: Few cancer mutations are inherited.
True
3. A tumor that can invade other issues is called tumor. If it does
not yet have the capacity to invade tissues, that tumor is called a
tumor
Malignant; benign
4. What are the two properties that are shared by cancer cells?
a) Abnormal growth/proliferation
b) The ability to relocate to other areas of the body (metastasis)
5. In order to be classified as a cancer, a cell must demonstrate what two
properties?
1. Abnormal growth/ proliferation
2. The ability to relocate to other areas of the body (Metastasis)
6. The two major therapies currently available to cancer patients are
and
Chemotherapy; radiation therapy
7. The fused "Philadelphia chromosome" in myelogenous leukemia
is form a mutated gene.
BCR-ABL
8. The fused chromosomes that forms a mutated BCR-ABL gene in
chronic myelogenous leukemia is known as the chromosome.
Philadelphia
9. Match the following terms to the correct description: Driver,
Passenger, Stem cell, tumor, metastasis.
Mutation that imparts a growth advantage on a cancer
Undifferentiated cell that can still become part of any system
Mutation that does not contribute to the phenotype of cancer
Defects in cells that lead to a loss of localization restraints
Solid mass growth resulting from a loss of proliferation control
10. Using the development of colon cancer as an example, explain how
the process of tumorigenesis can occur in distinct stages through the
accumulation of mutations.
The first stage of colon cancer involves the growth of a polyp, or
adenoma, which is a small cluster of cells that is defective in a gene
called APC. APC encodes for the differentiation of normal intestinal
cells, so the polyp accumulates undifferentiated cells. A polyp is still
, benign and localized to its spot in the colon. Over time, genetic
mutations occur in the polyp, and typically the mutation of the Kras
inherited False
2. True or false: Few cancer mutations are inherited.
True
3. A tumor that can invade other issues is called tumor. If it does
not yet have the capacity to invade tissues, that tumor is called a
tumor
Malignant; benign
4. What are the two properties that are shared by cancer cells?
a) Abnormal growth/proliferation
b) The ability to relocate to other areas of the body (metastasis)
5. In order to be classified as a cancer, a cell must demonstrate what two
properties?
1. Abnormal growth/ proliferation
2. The ability to relocate to other areas of the body (Metastasis)
6. The two major therapies currently available to cancer patients are
and
Chemotherapy; radiation therapy
7. The fused "Philadelphia chromosome" in myelogenous leukemia
is form a mutated gene.
BCR-ABL
8. The fused chromosomes that forms a mutated BCR-ABL gene in
chronic myelogenous leukemia is known as the chromosome.
Philadelphia
9. Match the following terms to the correct description: Driver,
Passenger, Stem cell, tumor, metastasis.
Mutation that imparts a growth advantage on a cancer
Undifferentiated cell that can still become part of any system
Mutation that does not contribute to the phenotype of cancer
Defects in cells that lead to a loss of localization restraints
Solid mass growth resulting from a loss of proliferation control
10. Using the development of colon cancer as an example, explain how
the process of tumorigenesis can occur in distinct stages through the
accumulation of mutations.
The first stage of colon cancer involves the growth of a polyp, or
adenoma, which is a small cluster of cells that is defective in a gene
called APC. APC encodes for the differentiation of normal intestinal
cells, so the polyp accumulates undifferentiated cells. A polyp is still
, benign and localized to its spot in the colon. Over time, genetic
mutations occur in the polyp, and typically the mutation of the Kras
