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Chronobiology – Biological Rhythms, Circadian Clock, SCN, Melatonin & Disorders (M.Sc. Life Science)

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These comprehensive M.Sc. level notes on Chronobiology cover the molecular, physiological, and clinical aspects of biological rhythms. The content includes: Biological rhythms: circadian, circannual, circalunar, circatidal, infradian, ultradian. Circadian system: properties, endogenous vs. entrainable, role of zeitgebers (light, food, social cues). Suprachiasmatic nucleus (SCN) – the master pacemaker; afferent and efferent pathways. Molecular clock: transcription–translation feedback loops (CLOCK, BMAL1, PER, CRY, kinases, phosphatases). Melatonin synthesis and its role in regulating sleep–wake cycles and seasonal rhythms. Circadian dysfunction: sleep disorders (ASPS, DSPS, non-24-hour syndrome), metabolic syndrome, aging-related disruption. Clinical implications: link between circadian disruption and cancer, depression, obesity, cardiovascular disease. Perfect for M.Sc. Life Sciences, Zoology, Biotechnology, Neuroscience students and for exam preparation (CSIR NET, GATE, ICMR, etc.).

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,BIOLOGICAL RHYTHMS
• Living organisms have evolved under constantly changing
environment due to the daily and yearly revolution of earth that
has driven the development of biological rhythms.

• Biological rhythms are cyclical changes that exist at genetic,
physiological and behavioral levels across taxa which enable the
organisms to predict and adapt to variety of climatic conditions.

• Based on the time scales, these are categorized as circannual,
circalunar, circatidal, infradian, ultradian and circadian rhythms.

, Biological Rhythms
Cyclic pattern of physiological changes or changes in activity most often synchronized with daily,
monthly, or annual cyclical changes in the environment.

Ultradian Less than 24 hour (h).
Rhythms Arenicola marina (lug worm) - feed on surface every 6-8 minutes


Circatidal Synchronized with tidal flow ( approximately 12.4 h)
Rhythms Crabs – times activity cycles to match tidal flow


Circalunar Synchronized with lunar cycles (29 days).
Rhythms Marine worm Platynereis sp. – Maturation and Spawning


Circannual 1 year long.
Rhythms Bird migration

More than 24 h
Infradian
Rhythms Human menstrual cycle


Circadian Endogenous, entrainable rhythms with a period close to 24 h
Rhythms 3

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MSc Life Science , Biology and Immunology Exam Notes (Trusted By Students)

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