NEPHROTIC SYNDROME
Dr. Karunakar. P
Senior Resident
Pediatrics
,Definition
• Nephrotic syndrome (NS) is the clinical manifestation of glomerular
diseases associated with heavy (nephrotic-range) proteinuria
• Nephrotic-range proteinuria is defined as proteinuria > 3.5 g/24 hr
a urine protein: creatinine ratio > 2
• The triad of clinical findings associated with nephrotic syndrome
arising from the large urinary losses of protein are hypoalbuminem
(≤2.5 g/dL), edema and hyperlipidemia (cholesterol > 200 mg/dL)
,
, • NS affects 1-3 per 100,000 children < 16 years of age
• NS without treatment - associated with a high risk of death, most
commonly from infections
• Fortunately, 80% of children with NS respond to corticosteroid therapy
• Although glucocorticoid therapy is standard therapy for NS, neither the
target cell nor the mechanism of action of steroids has been determined
Dr. Karunakar. P
Senior Resident
Pediatrics
,Definition
• Nephrotic syndrome (NS) is the clinical manifestation of glomerular
diseases associated with heavy (nephrotic-range) proteinuria
• Nephrotic-range proteinuria is defined as proteinuria > 3.5 g/24 hr
a urine protein: creatinine ratio > 2
• The triad of clinical findings associated with nephrotic syndrome
arising from the large urinary losses of protein are hypoalbuminem
(≤2.5 g/dL), edema and hyperlipidemia (cholesterol > 200 mg/dL)
,
, • NS affects 1-3 per 100,000 children < 16 years of age
• NS without treatment - associated with a high risk of death, most
commonly from infections
• Fortunately, 80% of children with NS respond to corticosteroid therapy
• Although glucocorticoid therapy is standard therapy for NS, neither the
target cell nor the mechanism of action of steroids has been determined
