Cardiovascular Drugs Master Bundle
✓ A Complete Guide To ACE Inhibitors, ARBs, Beta
Blockers, CCBs and Diuretics
→→→→→→→→→→→→
(1) Drug Class : ACE Inhibitor ( Angiotensin Converting Enzyme
Inhibitors)
ACE Inhibitors basically reduces the peripheral resistance and
work load (preload and afterload).
Examples:
• Captopril
• Enalapril
• Lisinopril
Mechanism Of Action:
• Inhibits the ACE, enzyme that converts the Angiotensin Ⅰà
Angiotensin Ⅱ.
, • Low Angiotensin Ⅱ means less vasoconstriction.
• Less amount of aldosterone secretion.
• Leads to low blood pressure and blood volume.
Adverse Effects:
Mnemonic: CAPT
• Cough( dry, persistent )
• Angioedema
• Proteinuria
• Taste change
Contradictions:
• Pregnancy
• History of Angioedema with ACE inhibitor
• Bilateral Renal Artery Stenosis
Clinical USES:
• Used to treat hypertension.
• Used to treat chronic heart failure (CHF).
• Used to treat Myocardial Infraction (POST MI).
Things To Remind:
• Dry cough = Bradykinin accumulation.
• Switching to Losartan may help if cough develops.
Exam Facts:
• ACE Inhibitor reduces mortality in patients with Heart
Failures and MI.
• Used by Diabetic patients for Kidney protection.
• First dose hypotension is common if you are using ACE
inhibitor.
✓ A Complete Guide To ACE Inhibitors, ARBs, Beta
Blockers, CCBs and Diuretics
→→→→→→→→→→→→
(1) Drug Class : ACE Inhibitor ( Angiotensin Converting Enzyme
Inhibitors)
ACE Inhibitors basically reduces the peripheral resistance and
work load (preload and afterload).
Examples:
• Captopril
• Enalapril
• Lisinopril
Mechanism Of Action:
• Inhibits the ACE, enzyme that converts the Angiotensin Ⅰà
Angiotensin Ⅱ.
, • Low Angiotensin Ⅱ means less vasoconstriction.
• Less amount of aldosterone secretion.
• Leads to low blood pressure and blood volume.
Adverse Effects:
Mnemonic: CAPT
• Cough( dry, persistent )
• Angioedema
• Proteinuria
• Taste change
Contradictions:
• Pregnancy
• History of Angioedema with ACE inhibitor
• Bilateral Renal Artery Stenosis
Clinical USES:
• Used to treat hypertension.
• Used to treat chronic heart failure (CHF).
• Used to treat Myocardial Infraction (POST MI).
Things To Remind:
• Dry cough = Bradykinin accumulation.
• Switching to Losartan may help if cough develops.
Exam Facts:
• ACE Inhibitor reduces mortality in patients with Heart
Failures and MI.
• Used by Diabetic patients for Kidney protection.
• First dose hypotension is common if you are using ACE
inhibitor.
