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NURS 615 PHARM EXAM 1 – MARYVILLE 2025
UPDATED ACTUAL EXAM WITH CORRECT
SOLUTIONS.
How does hypoalbuminemia affect the process of prescribing? -
correct answer- Low albumin = more free drug (bc the drug
can't bind to albumin aka protein) = increased adverse effects
What is a Black Box Warning: - correct answer- is considered a
contraindication to administer that drug.
What is the drugs half-life? - correct answer- Half-life
specifically means the amount of time it takes for an
administered drug to be halfway cleared from the system.
Peak of action: - correct answer- the time between drug
administration and maximum concentration of drug in the blood
stream. Best therapeutic effect.
Duration of action: - correct answer- the time between onset of
action and metabolism of drug below the minimum needed for
an effect. The length of time you have the drug in your system.
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According to the WHO what is the first step in the prescribing
process? - correct answer- The first step is to define the
patient's problem
The second step is to - correct answer- specify the therapeutic
objective
The third step is to - correct answer- choose which drug or
treatment is needed.
Step 4 of the WHO approach: - correct answer- Start the
treatment
Step 5 of the WHO approach: - correct answer- Educate the
patient
Step 6 of the WHO approach: - correct answer- Monitor the
treatment
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Phase 1 of drug development: - correct answer- The drug is
tested on healthy volunteers
Phase 2 of drug development: - correct answer- trials with
people who have the disease for which the drug is thought to
be effective
Phase 3 of drug development: - correct answer- Large numbers
of patients in medical research centers receive the drug in
phase 3. This larger sampling provides information about
infrequent or rare adverse effects. The FFA will approve a new
drug application if phase 3 studies are satisfactory.
Phase 4 of drug development: - correct answer- This phase is
voluntary and involves postmarket surveillance of the drug's
therapeutic effects at the completion of phase 3. The
pharmaceutical company receives reports from doctors and
other health care professionals about the therapeutic results
and adverse effects of the drug. Some medications, for
example, have been found to be toxic and have been removed
from the market after their initial release.
Explain first pass metabolism - correct answer- much of the
drug is lost in the absorption process. The liver metabolizes
many drugs, thus reduces the bioavailabilty of the drug.
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What is the fasted route of absorption: - correct answer- The
fastest route of absorption is inhalation, and not as mistakenly
considered the IV administration.
Why does the GI tract take longer to absorb? - correct answer-
The GI tract is lined with epithelial cells; drugs must permeate
through these cells in order to be absorbed into the circulatory
system.
What is One particular cellular barrier that may prevent
absorption of a given drug? - correct answer- the cell
membrane. Cell membranes are essentially lipid bilayers which
form a semipermeable membrane. Pure lipid bilayers are
generally permeable only to small and uncharged solutes,
hence whether or not a molecule is ionized will affect its
absorption, since ionic molecules are charged.
What is solubility? - correct answer- Solubility favors charged
species, permeability favors neutral species. Some molecules
have special exchange proteins and channels to facilitate
movement from the lumen into the circulation.
NURS 615 PHARM EXAM 1 – MARYVILLE 2025
UPDATED ACTUAL EXAM WITH CORRECT
SOLUTIONS.
How does hypoalbuminemia affect the process of prescribing? -
correct answer- Low albumin = more free drug (bc the drug
can't bind to albumin aka protein) = increased adverse effects
What is a Black Box Warning: - correct answer- is considered a
contraindication to administer that drug.
What is the drugs half-life? - correct answer- Half-life
specifically means the amount of time it takes for an
administered drug to be halfway cleared from the system.
Peak of action: - correct answer- the time between drug
administration and maximum concentration of drug in the blood
stream. Best therapeutic effect.
Duration of action: - correct answer- the time between onset of
action and metabolism of drug below the minimum needed for
an effect. The length of time you have the drug in your system.
,2 | Page
According to the WHO what is the first step in the prescribing
process? - correct answer- The first step is to define the
patient's problem
The second step is to - correct answer- specify the therapeutic
objective
The third step is to - correct answer- choose which drug or
treatment is needed.
Step 4 of the WHO approach: - correct answer- Start the
treatment
Step 5 of the WHO approach: - correct answer- Educate the
patient
Step 6 of the WHO approach: - correct answer- Monitor the
treatment
,3 | Page
Phase 1 of drug development: - correct answer- The drug is
tested on healthy volunteers
Phase 2 of drug development: - correct answer- trials with
people who have the disease for which the drug is thought to
be effective
Phase 3 of drug development: - correct answer- Large numbers
of patients in medical research centers receive the drug in
phase 3. This larger sampling provides information about
infrequent or rare adverse effects. The FFA will approve a new
drug application if phase 3 studies are satisfactory.
Phase 4 of drug development: - correct answer- This phase is
voluntary and involves postmarket surveillance of the drug's
therapeutic effects at the completion of phase 3. The
pharmaceutical company receives reports from doctors and
other health care professionals about the therapeutic results
and adverse effects of the drug. Some medications, for
example, have been found to be toxic and have been removed
from the market after their initial release.
Explain first pass metabolism - correct answer- much of the
drug is lost in the absorption process. The liver metabolizes
many drugs, thus reduces the bioavailabilty of the drug.
, 4 | Page
What is the fasted route of absorption: - correct answer- The
fastest route of absorption is inhalation, and not as mistakenly
considered the IV administration.
Why does the GI tract take longer to absorb? - correct answer-
The GI tract is lined with epithelial cells; drugs must permeate
through these cells in order to be absorbed into the circulatory
system.
What is One particular cellular barrier that may prevent
absorption of a given drug? - correct answer- the cell
membrane. Cell membranes are essentially lipid bilayers which
form a semipermeable membrane. Pure lipid bilayers are
generally permeable only to small and uncharged solutes,
hence whether or not a molecule is ionized will affect its
absorption, since ionic molecules are charged.
What is solubility? - correct answer- Solubility favors charged
species, permeability favors neutral species. Some molecules
have special exchange proteins and channels to facilitate
movement from the lumen into the circulation.
