NR507 Midterm Study Guide: Advanced Pathophysiology
NR507 Midterm Study Guide: Advanced Pathophysiology
Hypersensitivity Reactions (McCance Ch. 9)
Type I Immediate (IgE-Mediated)
- Mechanism: IgE binds to mast cells degranulation histamine release.
- Examples: Anaphylaxis, hay fever.
- Symptoms: Wheezing, itching, hypotension.
- Treatment: Epinephrine.
Type II Cytotoxic (Tissue-Specific)
- Mechanism: IgG/IgM antibodies bind to antigens on cells complement activation cell
damage.
- Examples: Graves disease (stimulatory), transfusion reaction (destructive).
Type III Immune Complex-Mediated
- Mechanism: Antigen-antibody complexes deposit in tissues inflammation.
- Examples: SLE, RA, post-streptococcal glomerulonephritis.
Type IV Delayed (T-Cell Mediated)
- Mechanism: T-cell activation cytokine release inflammation.
- Examples: Poison ivy, TB test.
Immunodeficiency & Autoimmunity (McCance Ch. 9 + E-dapt: Immune Response)
- Primary Immunodeficiency: Genetic defect (e.g., CVI) low immunoglobulins.
NR507 Midterm Study Guide: Advanced Pathophysiology
Hypersensitivity Reactions (McCance Ch. 9)
Type I Immediate (IgE-Mediated)
- Mechanism: IgE binds to mast cells degranulation histamine release.
- Examples: Anaphylaxis, hay fever.
- Symptoms: Wheezing, itching, hypotension.
- Treatment: Epinephrine.
Type II Cytotoxic (Tissue-Specific)
- Mechanism: IgG/IgM antibodies bind to antigens on cells complement activation cell
damage.
- Examples: Graves disease (stimulatory), transfusion reaction (destructive).
Type III Immune Complex-Mediated
- Mechanism: Antigen-antibody complexes deposit in tissues inflammation.
- Examples: SLE, RA, post-streptococcal glomerulonephritis.
Type IV Delayed (T-Cell Mediated)
- Mechanism: T-cell activation cytokine release inflammation.
- Examples: Poison ivy, TB test.
Immunodeficiency & Autoimmunity (McCance Ch. 9 + E-dapt: Immune Response)
- Primary Immunodeficiency: Genetic defect (e.g., CVI) low immunoglobulins.
