Clinical Pharmacy Slides; Organized & Simplified
by Haris Saeed
CLINICAL PHARMACY-II
Dr. Abuzir Khan
Department of Pharmacy
University of Peshawar
Student Name
Class: 5th Professional Year
Section:
Roll No.
Mobile No.
Page 1 of 173
, Index
S. No. Title Page No.
1 Rational Use of Drugs
2 Introduction to Essential Drugs
3 Drug Utilization Review
4 Clinical Pharmacokinetics
5 Pharmaceutical Care
6
7 Clinical Toxicology
8 Safe Intravenous Therapy and Hazards
9 Non-compliance
10 Disease Management
V. Central Nervous System
a. Stroke
b. Epilepsy
c. Psychosis
VI. Infectious Diseases
a. Meningitis
b. Tuberculosis
VII. Endocrinological Disorders
a. Diabetes Mellitus
b. Hyperthyroidism
c. Hypothyroidism
d. Hypopituitarism
VIII. Nephrology
a. Acute Renal Failure
b. Urinary Tract Infections
IX. Hematology
a. Thrombocytopenia
Page 2 of 173
, PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL CHEMISTRY) (Practical)
Paper 6 Marks 100
NOTE: Practical of the subject shall be designed from time to time on the basis of the above
mentioned theoretical topics and availability of the facilities e.g. Estimation of functional groups;
Carboxylic, Hydroxy, Amino and Nitro groups; Determination of Molecular weights of Organic
Compounds. Synthesis of Paracetamol, Salicylic Acid, Methyl salicylate, Azobenzene, Benzoic Acid,
5-Hydroxy-1, 3-benzoxazol-2-one, Aspirin, P-nitrosophenol, 3-nitrophthalic acid, Chloro-benzoic
acid. Assay of the Drugs like Sulpha drugs, Aspirin, Paracetamol, Benzyl Penicillin. Inorganic
Preparations (Note: A minimum of 20 practicals will be conducted).
PHARMACY PRACTICE-VI (CLINICAL PHARMACY-II) (Theory)
Paper 2 Marks 100
1. RATIONAL USE OF DRUGS: Rational Prescribing, Rational Dispensing, Problems of Irrational
Drug Use, Learning about drug use problem, Sampling to study drug use, Indicators of drug use.
2. INTRODUCTION TO ESSENTIAL DRUGS: Criteria for selection, Usage and Advantages.
Development of EDL.
3. DRUG UTILZATION EVALUATION & DRUG UTILIZATIONREVIEW (DUE/DUR):
Development of protocol of use of few very low therapeutic index drug groups like Steroids,
Vancomycin and Cimetidine.
4. CLINICAL PHARMACOKINETICS: Therapeutic Drug Monitoring of Digoxin, Theophyline,
Gentamycin, Lithium, Phenytoin, Cabamazepine, Phenobarbitone, Valproic Acid, Cyclosporins
and Vancomycin.
5. PHARMACEUTICAL CARE, ITS SCOPE, MANAGEMENT AND APPLICATION OF
CARE PLAN:
6. CLINICAL THERAPEUTICS: General Strategy: Terminology of Disease. Management and
Treatment. Drug Selection.
7. CLINICAL TOXICOLOGY:
(a) General information. Role of pharmacist in treatment of poisoning and general
management of poisoning & over dosage. Role and Status of Poison Control Centre.
(b) Antidotes and their mechanism of action.
8. SAFE INTRAVENOUS THERAPY & HAZARDS OF IV THERAPY
9. NON-COMPLIANCE: Definition, introduction and importance, Extent of non-compliance,
Methods of assessment, Reasons for non-compliance, Strategies for improving compliance.
99
Page 3 of 173
, 10. DISEASE MANAGEMENT:
Unit V: Central nervous system unit (Stroke, Epilepsy, Psychosis)
Unit VI: Infectious diseases (Meningitis, tuberculosis, dermatological infections, Rabies,
Urinary track infection, Malaria fever, Typhoid fever, Fungal infections of skin, AIDS,
Dengue fever, Common Cold, Pharyngitis & Tonsillitis, Conjunctivitis)
Unit VII: Endocrinology Unit (Diabetes Mellitus, Hyper/Hypo-thyroidism, pituitary gland
non-malignant disorders)
Unit VIII: Oncology Unit (Types of tumors, Brief introduction to oncological diseases e.g.
prostate cancer, breast cancer, lungs cancer )
Unit IX: Nephrology Unit (Renal failure, nephrotic syndrom)
Unit X: Hematology Unit (Bleeding disorders/coagulopathies/clotting disorders e.g.
thrombocytopenia, hemophilia, Vit. K deficiency, Anemia).
PHARMACY PRACTICE-VI (CLINICAL PHARMACY-II) (Practical)
Paper 7 Marks 100
Clerkship in the Clinical Setting. A project Related to Clinical Pharmacy Practices will be
completed by the students and will be evaluated by the external examiner.
Student are required to take/present verbal presentation, communication, written and
problem-solving skills, critical analysis of data and provision of care through a weekly
conference and projects
PHARMACEUTICS-VII (PHARMACEUTICAL TECHNOLOGY) (Theory)
Paper 3 Marks 100
1. PRINCIPLES OF PHARMACEUTICAL FORMULATION AND DOSAGE FORM DESIGN:
Need for dosage form; Pre-formulation Studies; Product Formulation.
2. ADVANCED GRANULATION TECHNOLOGY (DESIGN & PRACTICE):
Spray Drying Granulation Technology; Roller Compaction Technology; Extrusion/Spheronization as
a Granulation Technique; Single-Pot Processing Granulation Technology: Rapid Release
Granulation Technique; Particle Coating by Centrifugation Granulation Technology.
3. POLYMERS USED IN DRUG DELIVERY SYSTEMS:
4. NOVEL DRUG DELIVERY SYSTEM (DDS):
Sustained/ Controlled Release Drug Delivery System
i. Microencapsulation technique
Coacervation
Solvent evaporation
Interfacial polymerization
Spray drying
ii. Developmental aspects of Matrix and Reservoir Systems
100
Page 4 of 173
by Haris Saeed
CLINICAL PHARMACY-II
Dr. Abuzir Khan
Department of Pharmacy
University of Peshawar
Student Name
Class: 5th Professional Year
Section:
Roll No.
Mobile No.
Page 1 of 173
, Index
S. No. Title Page No.
1 Rational Use of Drugs
2 Introduction to Essential Drugs
3 Drug Utilization Review
4 Clinical Pharmacokinetics
5 Pharmaceutical Care
6
7 Clinical Toxicology
8 Safe Intravenous Therapy and Hazards
9 Non-compliance
10 Disease Management
V. Central Nervous System
a. Stroke
b. Epilepsy
c. Psychosis
VI. Infectious Diseases
a. Meningitis
b. Tuberculosis
VII. Endocrinological Disorders
a. Diabetes Mellitus
b. Hyperthyroidism
c. Hypothyroidism
d. Hypopituitarism
VIII. Nephrology
a. Acute Renal Failure
b. Urinary Tract Infections
IX. Hematology
a. Thrombocytopenia
Page 2 of 173
, PHARMACEUTICAL CHEMISTRY-IV (MEDICINAL CHEMISTRY) (Practical)
Paper 6 Marks 100
NOTE: Practical of the subject shall be designed from time to time on the basis of the above
mentioned theoretical topics and availability of the facilities e.g. Estimation of functional groups;
Carboxylic, Hydroxy, Amino and Nitro groups; Determination of Molecular weights of Organic
Compounds. Synthesis of Paracetamol, Salicylic Acid, Methyl salicylate, Azobenzene, Benzoic Acid,
5-Hydroxy-1, 3-benzoxazol-2-one, Aspirin, P-nitrosophenol, 3-nitrophthalic acid, Chloro-benzoic
acid. Assay of the Drugs like Sulpha drugs, Aspirin, Paracetamol, Benzyl Penicillin. Inorganic
Preparations (Note: A minimum of 20 practicals will be conducted).
PHARMACY PRACTICE-VI (CLINICAL PHARMACY-II) (Theory)
Paper 2 Marks 100
1. RATIONAL USE OF DRUGS: Rational Prescribing, Rational Dispensing, Problems of Irrational
Drug Use, Learning about drug use problem, Sampling to study drug use, Indicators of drug use.
2. INTRODUCTION TO ESSENTIAL DRUGS: Criteria for selection, Usage and Advantages.
Development of EDL.
3. DRUG UTILZATION EVALUATION & DRUG UTILIZATIONREVIEW (DUE/DUR):
Development of protocol of use of few very low therapeutic index drug groups like Steroids,
Vancomycin and Cimetidine.
4. CLINICAL PHARMACOKINETICS: Therapeutic Drug Monitoring of Digoxin, Theophyline,
Gentamycin, Lithium, Phenytoin, Cabamazepine, Phenobarbitone, Valproic Acid, Cyclosporins
and Vancomycin.
5. PHARMACEUTICAL CARE, ITS SCOPE, MANAGEMENT AND APPLICATION OF
CARE PLAN:
6. CLINICAL THERAPEUTICS: General Strategy: Terminology of Disease. Management and
Treatment. Drug Selection.
7. CLINICAL TOXICOLOGY:
(a) General information. Role of pharmacist in treatment of poisoning and general
management of poisoning & over dosage. Role and Status of Poison Control Centre.
(b) Antidotes and their mechanism of action.
8. SAFE INTRAVENOUS THERAPY & HAZARDS OF IV THERAPY
9. NON-COMPLIANCE: Definition, introduction and importance, Extent of non-compliance,
Methods of assessment, Reasons for non-compliance, Strategies for improving compliance.
99
Page 3 of 173
, 10. DISEASE MANAGEMENT:
Unit V: Central nervous system unit (Stroke, Epilepsy, Psychosis)
Unit VI: Infectious diseases (Meningitis, tuberculosis, dermatological infections, Rabies,
Urinary track infection, Malaria fever, Typhoid fever, Fungal infections of skin, AIDS,
Dengue fever, Common Cold, Pharyngitis & Tonsillitis, Conjunctivitis)
Unit VII: Endocrinology Unit (Diabetes Mellitus, Hyper/Hypo-thyroidism, pituitary gland
non-malignant disorders)
Unit VIII: Oncology Unit (Types of tumors, Brief introduction to oncological diseases e.g.
prostate cancer, breast cancer, lungs cancer )
Unit IX: Nephrology Unit (Renal failure, nephrotic syndrom)
Unit X: Hematology Unit (Bleeding disorders/coagulopathies/clotting disorders e.g.
thrombocytopenia, hemophilia, Vit. K deficiency, Anemia).
PHARMACY PRACTICE-VI (CLINICAL PHARMACY-II) (Practical)
Paper 7 Marks 100
Clerkship in the Clinical Setting. A project Related to Clinical Pharmacy Practices will be
completed by the students and will be evaluated by the external examiner.
Student are required to take/present verbal presentation, communication, written and
problem-solving skills, critical analysis of data and provision of care through a weekly
conference and projects
PHARMACEUTICS-VII (PHARMACEUTICAL TECHNOLOGY) (Theory)
Paper 3 Marks 100
1. PRINCIPLES OF PHARMACEUTICAL FORMULATION AND DOSAGE FORM DESIGN:
Need for dosage form; Pre-formulation Studies; Product Formulation.
2. ADVANCED GRANULATION TECHNOLOGY (DESIGN & PRACTICE):
Spray Drying Granulation Technology; Roller Compaction Technology; Extrusion/Spheronization as
a Granulation Technique; Single-Pot Processing Granulation Technology: Rapid Release
Granulation Technique; Particle Coating by Centrifugation Granulation Technology.
3. POLYMERS USED IN DRUG DELIVERY SYSTEMS:
4. NOVEL DRUG DELIVERY SYSTEM (DDS):
Sustained/ Controlled Release Drug Delivery System
i. Microencapsulation technique
Coacervation
Solvent evaporation
Interfacial polymerization
Spray drying
ii. Developmental aspects of Matrix and Reservoir Systems
100
Page 4 of 173
