PHARMACOLOGY EXAM 1 WITH
QUESTIONS AND WELL REVISED
ANSWERS FROM A VERIFIED SOURCE
() 100% GUARANTEE PASS!!!
pharmacokinetics - CORRECT ANSWER-relationship between drug
dosage and concentration in plasma over time, determines onset,
duration, and intensity of drug
pharmacodynamics - CORRECT ANSWER-relationship between drug
concentration over time and therapeutic response
chemical specificity for receptors - CORRECT ANSWER-specificity
between receptors and bonds, EX strict structural requirements for
binding
receptor saturability - CORRECT ANSWER-only a finite number of
receptors that can be occupied
,receptor affinity - CORRECT ANSWER-measure of attraction
between drug and receptor
drug potency - CORRECT ANSWER-dose required to have certain
effect, related to affinity of receptor
ED50 - CORRECT ANSWER-dose which produces 50% of maximum
effect, used to compare drugs in terms of potency
drug efficacy - CORRECT ANSWER-maximal effect achievable for a
drug, related to number of receptor/complexes formed, intrinsic
activity of drug in activating receptor
full agonist - CORRECT ANSWER-affinity to, and full activator, of
receptor (high intrinsic activity/efficacy), increases activity above
basal level of receptor where receptor has a constitutive (intrinsic
basal) level of activity in the absence of a ligand
inverse agonist - CORRECT ANSWER-affinity to, and full activator of
receptor (high intrinsic activity/efficacy), but has exact opposite
effect of full agonist (metoprolol), decreases activity below basal level
of receptor where receptor has a constitutive (intrinsic basal) level of
activity in the absence of a ligand
, partial agonist - CORRECT ANSWER-affinity to receptor but only
partially activates a receptor, produces less than the ceiling effect of
a full agonist
pure antagonist - CORRECT ANSWER-affinity to receptor but
produces no activation, dose curve is a straight line across the bottom
of an XY graph (EX oraverse vasodilates, overcoming the
vasocontriction of the LA)
neutral antgonist - CORRECT ANSWER-has no activity in the absence
of an agonist or inverse agonist but can block either's activity
competitive antagonist - CORRECT ANSWER-lacks efficacy,
competes with agonists for binding sites, inhibitory effect can be
overcome by increasing concentration of competing agonist
every drug produces a variety of effects, we hope we can get
separation from things we want and adverse side effects, this is
different for every patient - CORRECT ANSWER-
know the second slide on page 10 of principles of drugs - CORRECT
ANSWER-which drugs is most potent, least potenet, most efficient
and least efficient
QUESTIONS AND WELL REVISED
ANSWERS FROM A VERIFIED SOURCE
() 100% GUARANTEE PASS!!!
pharmacokinetics - CORRECT ANSWER-relationship between drug
dosage and concentration in plasma over time, determines onset,
duration, and intensity of drug
pharmacodynamics - CORRECT ANSWER-relationship between drug
concentration over time and therapeutic response
chemical specificity for receptors - CORRECT ANSWER-specificity
between receptors and bonds, EX strict structural requirements for
binding
receptor saturability - CORRECT ANSWER-only a finite number of
receptors that can be occupied
,receptor affinity - CORRECT ANSWER-measure of attraction
between drug and receptor
drug potency - CORRECT ANSWER-dose required to have certain
effect, related to affinity of receptor
ED50 - CORRECT ANSWER-dose which produces 50% of maximum
effect, used to compare drugs in terms of potency
drug efficacy - CORRECT ANSWER-maximal effect achievable for a
drug, related to number of receptor/complexes formed, intrinsic
activity of drug in activating receptor
full agonist - CORRECT ANSWER-affinity to, and full activator, of
receptor (high intrinsic activity/efficacy), increases activity above
basal level of receptor where receptor has a constitutive (intrinsic
basal) level of activity in the absence of a ligand
inverse agonist - CORRECT ANSWER-affinity to, and full activator of
receptor (high intrinsic activity/efficacy), but has exact opposite
effect of full agonist (metoprolol), decreases activity below basal level
of receptor where receptor has a constitutive (intrinsic basal) level of
activity in the absence of a ligand
, partial agonist - CORRECT ANSWER-affinity to receptor but only
partially activates a receptor, produces less than the ceiling effect of
a full agonist
pure antagonist - CORRECT ANSWER-affinity to receptor but
produces no activation, dose curve is a straight line across the bottom
of an XY graph (EX oraverse vasodilates, overcoming the
vasocontriction of the LA)
neutral antgonist - CORRECT ANSWER-has no activity in the absence
of an agonist or inverse agonist but can block either's activity
competitive antagonist - CORRECT ANSWER-lacks efficacy,
competes with agonists for binding sites, inhibitory effect can be
overcome by increasing concentration of competing agonist
every drug produces a variety of effects, we hope we can get
separation from things we want and adverse side effects, this is
different for every patient - CORRECT ANSWER-
know the second slide on page 10 of principles of drugs - CORRECT
ANSWER-which drugs is most potent, least potenet, most efficient
and least efficient
